Results 61 to 70 of about 86,968 (315)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

THE CERVICAL CANCER SCREENING - UNSOLVED PROBLEMS

Исследования и практика в медицине, 2015
The problem of cervical cancer (CC) for many decades continues to be the center of attention leading foreign and domestic oncologists. Malignant cervical tumors occupy the leading position among malignant neoplasms of reproductive system in women, second
A. D. Kaprin, E. G. Novikova, O. I. Trushina, O. P. Gretzova   +3 more
doaj   +1 more source

Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations [PDF]

, 2014
Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by ...
Bartnik, Ewa, Bryk, Jarek, Futyma, Konrad, Lorenc, Anna, Miotla, Pawel, Putowski, Lechoslaw, Semczuk, Andrzej   +6 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Stromal Sarcoma of the Uterine Cervix in A Virgin 22 Years Old Girl

پزشکی بالینی ابن سینا, 2000
This report describes a rare case of uterine cervical stromal sarcoma    in a virgin 22  years old  girl  before  sexual experience. She  admited for    recurrent   pyelonephritis  and  pelvic  mass  (vaginal  origin).
Maliheh Arab, Mohammad Javad Soleimani, Zarrin Zaman Parvar   +2 more
doaj  

Malignant tumors arising de novo in immunosuppressed organ transplant recipients [PDF]

, 1972
De novo malignant tumors have been observed throughout the world in 75 chronic survivors of organ transplantation, including 16 of our own patients. The incidence of tumors was approximately 80 times greater than in the average population in a comparable
Penn, I, Starzl, TE
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia [PDF]

, 2015
BACKGROUND: Cervical intra-epithelial neoplasia (CIN) typically occurs in young women of reproductive age. Although several studies have reported the impact that cervical conservative treatment may have on obstetric outcomes, there is much less evidence
Acharya, Albrechtsen, Anderson, Arbyn, Arbyn, Arbyn, Arbyn, Armarnik, Begg, Berretta, Bigrigg, Blomfield, Braet, Bruinsma, Bruinsma, Buller, Castanon, Castanon, Chew, Cochran, Conner, Cruickshank, Deeks, Dersimonian, Egger, Ferenczy, Forsmo, Founta, Frega, Gordon, GRADE Working Group 2004 GRADE Working Group, Haffenden, Hagen, Hammond, Heinonen, Higgins, Holmes, Holmes, Human Microbiome Project Consortium, Jakobsson, Jiménez, Jones, Kalliala, Kalliala, Keijser, Kennedy, Khalid, Kitchener, Kuoppala, Kyrgiou, Kyrgiou, Kyrgiou, Kyrgiou, Kyrgiou, Larsson, Li, Luesley, Macvicar, Martin-Hirsch, Mathevet, Mazouni, Michelin, Moher, NHS Cervical Screening Programme, Nicholson, Noehr, Nuovo, Paraskevaidis, Paraskevaidis, Paraskevaidis, Phadnis, Philipp, Prendiville, Quinn, Raio, Ravel, Sagot, Shanbhag, Sjøborg, Soutter, Spitzer, Spracklen, Steichen, Strander, Stroup, Suarez, Tan, Turlington, Vijver, Weber   +89 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source