Results 51 to 60 of about 808,193 (291)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Markov chain modeling of daily rainfall in Lay Gaint Woreda, South Gonder Zone, Ethiopia

Journal of Degraded and Mining Lands Management, 2018
Information on seasonal Kiremet and seasonal Belg rainfall amount is important in the rain fed agriculture of Ethiopia since more than 85% of the population is dependent on agriculture particularly on rain fed farming practices.
Birhan Getachew, Menberu Teshome
doaj   +1 more source

The importance of early immunotherapy in patients with faciobrachial dystonic seizures. [PDF]

, 2018
Faciobrachial dystonic seizures and limbic encephalitis closely associate with antibodies to leucine-rich glioma-inactivated 1 (LGI1). Here, we describe 103 consecutive patients with faciobrachial dystonic seizures and LGI1 antibodies to understand ...
Bi, Mian, Bien, Christian, Chu, Kon, Farooque, Pue, Gelfand, Jeffrey, Geschwind, Michael, Hirsch, Lawrence, Irani, Sarosh, Lang, Bethan, Leite, Maria, Makuch, Mateusz, Murchison, Andrew, Somerville, Ernest, Thompson, Julia, Vincent, Angela, Waters, Patrick   +15 more
core  

Tobacco smoking and all-cause mortality in a large Australian cohort study: findings from a mature epidemic with current low smoking prevalence [PDF]

, 2015
This study finds that up to two-thirds of deaths in current smokers  in Australia can be attributed to smoking. Abstract Background The smoking epidemic in Australia is characterised by historic levels of prolonged smoking, heavy smoking, very ...
Alan D. Lopez, Bette Liu, Ellie Paige, Emily Banks, Freddy Sitas, Grace Joshy, Marianne F. Weber, Robert Grenfell, Sam Egger, Valerie Beral   +9 more
core   +3 more sources

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Expanding the reach of the Quitline by engaging volunteers to market it in hospitals and shopping venues – a pilot study

Tobacco Induced Diseases, 2015
Background In Canada, although there are periodic media campaigns to raise awareness of Quitlines, these services are underused. We sought to determine if a dedicated kiosk, similar to that used in the retail industry but staffed by volunteers trained in
Fadi Hammal, Alyssa Chappell, Katherine Pohoreski, Barry A. Finegan   +3 more
doaj   +1 more source

Managing smoking cessation [PDF]

Canadian Medical Association Journal, 2016
Most people who smoke in Canada (64.4%) report that they want to quit, and half (49.6%) have tried to quit in the past year.[1][1] Unfortunately, less than five percent of such attempts result in long-term abstinence.
Robert D, Reid, Gillian, Pritchard, Kathryn, Walker, Debbie, Aitken, Kerri-Anne, Mullen, Andrew L, Pipe   +5 more
openaire   +2 more sources

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Metabolic Changes Following Smoking Cessation in Patients with Type 2 Diabetes Mellitus

Biomedicines
Background: Smoking cessation is crucial for reducing complications of type 2 diabetes mellitus (T2DM), but associated weight gain can worsen glycemic control, discouraging quitting attempts.
Stamatina Driva, Aliki Korkontzelou, Serena Tonstad, Nikolaos Tentolouris, Eleni Litsiou, Vasiliki Vasileiou, Alice G. Vassiliou, Vassiliki Saltagianni, Paraskevi Katsaounou   +8 more
doaj   +1 more source

Tobacco Treatment Guideline for High Risk Groups: A pilot study in patients with Chronic Obstructive Pulmonary Disease

Tobacco Induced Diseases, 2018
Introduction Smoking cessation is a key clinical intervention for reducing progressive lung destruction and lung function deterioration in patients with Chronic Obstructive Pulmonary Disease (COPD).
Antigona C. Trofor, Sophia Papadakis, Lucia Lotrean, Ioana Buculei- Porosnicu, Vergina K. Vyzikidou, Vaso Evangelopoulou, Constantine Vardavas, Panagiotis Behrakis   +7 more
doaj   +1 more source