Results 51 to 60 of about 433,496 (313)

Cytisine for smoking cessation [PDF]

Canadian Medical Association Journal, 2018
Cytisine, primarily derived from the Cytisus laburnum plant (which inspired the development of varenicline), is a partial agonist of the α4β2 nicotinic acetylcholine receptor responsible for central effects of nicotine.[1][1] Oral cytisine reaches peak concentration two hours postdose[2][2] and ...
Taleen, Karnieg, Xiang, Wang
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effects of depressive symptoms on antecedents of lapses during a smoking cessation attempt: An ecological momentary assessment study [PDF]

, 2014
AIMS: To investigate pathways through which momentary negative affect and depressive symptoms affect risk of lapse during smoking cessation attempts. DESIGN: Ecological Momentary Assessment was carried out during two weeks after an unassisted smoking ...
Jeannette Brodbeck, Monica S. Bachmann, Hans Joerg Znoj, Brodbeck, Jeannette, Bachmann, Monica S., Znoj, Hans Joerg, Anna Brown, Brown, Anna, Znoj, Hans Jörg   +8 more
core   +1 more source

Markov chain modeling of daily rainfall in Lay Gaint Woreda, South Gonder Zone, Ethiopia

Journal of Degraded and Mining Lands Management, 2018
Information on seasonal Kiremet and seasonal Belg rainfall amount is important in the rain fed agriculture of Ethiopia since more than 85% of the population is dependent on agriculture particularly on rain fed farming practices.
Birhan Getachew, Menberu Teshome
doaj   +1 more source

Incentives for smoking cessation [PDF]

Cochrane Database of Systematic Reviews, 2015
Material or financial incentives are widely used in an attempt to precipitate or reinforce behaviour change, including smoking cessation. They operate in workplaces, in clinics and hospitals, and to a lesser extent within community programmes. In this third update of our review we now include trials conducted in pregnant women, to reflect the ...
Kate, Cahill, Jamie, Hartmann-Boyce, Rafael, Perera   +2 more
openaire   +2 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

GPs' views on new national smoking cessation guidelines [PDF]

, 2001
Objectives: To assess GPs? views on recently published national smoking cessation guidelines that form the foundation of the government?s smoking cessation strategy.Design: Postal survey of a random sample of GPs.
McEwen, A, Akotia, N, West, R
core  

Expanding the reach of the Quitline by engaging volunteers to market it in hospitals and shopping venues – a pilot study

Tobacco Induced Diseases, 2015
Background In Canada, although there are periodic media campaigns to raise awareness of Quitlines, these services are underused. We sought to determine if a dedicated kiosk, similar to that used in the retail industry but staffed by volunteers trained in
Fadi Hammal, Alyssa Chappell, Katherine Pohoreski, Barry A. Finegan   +3 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Berlin's medical students' smoking habits, knowledge about smoking and attitudes toward smoking cessation counseling [PDF]

, 2010
Background: Diseases associated with smoking are a foremost cause of premature death in the world, both in developed and developing countries. Eliminating smoking can do more to improve health and prolong life than any other measure in the field of ...
Raupach Tobias, Groneberg, Jan David Alexander, Raupach, Tobias, Welte, Tobias, Meyer-Falcke, Andreas, Vitzthum Karin, Quarcoo David, Andreas Meyer-Falcke, Kusma Bianca, Bianca Kusma, Tobias Welte, Tobias Raupach, Stefanie Mache, Karin Vitzthum, David A Groneberg, Groneberg, David A., Vitzthum, Karin, Groneberg David A, Mache Stefanie, Meyer-Falcke Andreas, Kusma, Bianca, Welte Tobias, Mache, Stefanie, Quarcoo, David, David Quarcoo   +24 more
core   +1 more source