Results 51 to 60 of about 104,496 (248)

Parametric Study of a Fully Passive Oscillating Foil on a Swinging Arm

open access: yesEnergies
A NACA 0015 airfoil is connected to a swinging arm by springs and dampers and is let loose in an incompressible and viscous flow at a Reynolds number of 3.9×106.
Dominic Cloutier   +2 more
doaj   +1 more source

Tumor‐Derived Interleukin 35 Promotes Fibrosis in the Tumor Microenvironment of Pancreatic Cancer by Activating Pancreatic Stellate Cells

open access: yesAdvanced Science, EarlyView.
This study demonstrates that tumor‐derived IL‐35 promotes pancreatic cancer fibrosis by indirectly activating pancreatic stellate cells through IGFBP2/IGF‐1R/PI3K‐Akt and Tsp‐1/TGF‐β pathways. IL‐35 blockade reduces stromal fibrosis, restores chemosensitivity, and synergizes with gemcitabine‐based regimens, highlighting IL‐35 as a promising therapeutic
Hui Li   +14 more
wiley   +1 more source

Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang   +16 more
wiley   +1 more source

Thermal Shielding and Vapor Transport Enhancement in MOF‐Enabled Membranes for Membrane Distillation

open access: yesAdvanced Science, EarlyView.
A metal–organic framework‐enabled membrane (MEM) with a hierarchical porous structure is developed for thermal‐efficient membrane distillation. By embedding ZIF‐8 onto PH nanofibers, the MEM achieves low thermal conductivity and significantly enhances vapor flux and thermal efficiency.
Xiaolu Li   +14 more
wiley   +1 more source

Spatiotemporal Analysis of Web News Archives for Crime Prediction

open access: yesApplied Sciences, 2020
In today’s world, security is the most prominent aspect which has been given higher priority. Despite the rapid growth and usage of digital devices, lucrative measurement of crimes in under-developing countries is still challenging.
Areeba Umair   +5 more
doaj   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

open access: yesAdvanced Science, EarlyView.
Early tumors exhibit normoxic immune activation, while advanced stages show hypoxia‐driven immune exhaustion and suppression. Distinct cell populations—including STAT1‐driven exhausted CD8⁺ T cells, POSTN⁺ fibroblasts, FKBP11⁺ plasma cells, C5 tumor cells, and LGMN⁺ macrophages—cooperate to establish a hypoxia‐enriched, immunosuppressive ...
Bomiao Qing   +10 more
wiley   +1 more source

Subvoxel Control of Fiber Orientation via Multidirectional Shearing in 3D Printing

open access: yesAdvanced Science, EarlyView.
A novel 3D printing technique enables subvoxel control of fiber orientation in all three directions through multidirectional shearing using nozzle rotation and inclination. It allows localized and tunable mechanical and thermal responses through programmable microstructures within a strand.
Berin Šeta   +5 more
wiley   +1 more source

Unique Aerofoil‐Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale‐up

open access: yesAdvanced Science, EarlyView.
This study presents aerofoiled microfluidic structures optimized for efficient mixing and lipid nanoparticle (LNP) formation across broad flow rates. Based on this design, two dedicated systems are introduced: MiNANO‐form for high‐throughput formulation screening and MiNANO‐scale for continuous large‐scale production, enabling reproducible, high ...
Dongsheng Liu   +8 more
wiley   +1 more source

Numerical Investigation of Nanofluid Forced Convection in Channels with Discrete Heat Sources

open access: yesJournal of Applied Mathematics, 2012
Numerical simulation is performed to investigate the laminar force convection of Al2O3/water nanofluid in a flow channel with discrete heat sources. The heat sources are placed on the bottom wall of channel which produce much thermal energy that must be ...
Payam Rahim Mashaei   +2 more
doaj   +1 more source

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