Results 161 to 170 of about 119,123 (196)

Molecular and functional analysis of the novel cfr(D) linezolid resistance gene identified in Enterococcus faecium.

Journal of Antimicrobial Chemotherapy, 2020
OBJECTIVES To characterize the novel cfr(D) gene identified in an Enterococcus faecium clinical isolate (15-307.1) collected from France. METHODS The genome of 15-307.1 was entirely sequenced using a hybrid approach combining short-read (MiSeq ...
F. Guérin, M. Sassi, L. Dejoies, A. Zouari, Sacha Schutz, Sophie Potrel, M. Auzou, Anaïs Collet, D. Lecointe, G. Auger, V. Cattoir   +10 more
semanticscholar   +1 more source

Assessing the advantages of CFR-PEEK over titanium spinal stabilization implants in proton therapy—a phantom study

Physics in Medicine and Biology, 2020
High-density materials, such as titanium, used for spinal stabilization, introduces several critical issues in proton therapy (PT). Artefacts affect both contouring and dose calculation.
R. Poel, F. Belosi, F. Albertini, M. Walser, A. Gisep, A. Lomax, D. Weber   +6 more
semanticscholar   +1 more source

Co-existence of the oxazolidinone resistance genes cfr and optrA on two transferable multiresistance plasmids in one Enterococcus faecalis isolate from swine.

International Journal of Antimicrobial Agents, 2020
OBJECTIVES This study aimed at identifying and characterizing oxazolidinone resistance genes cfr and optrA in Enterococcus isolates. METHODS We screened 293 Enterococcus isolates for the presence of cfr and optrA genes by PCR.
Lin Chen, Dongdong Han, Ziyun Tang, J. Hao, Wenguang Xiong, Zhen-Ling Zeng   +5 more
semanticscholar   +1 more source

LRE-Finder, a Web tool for detection of the 23S rRNA mutations and the optrA, cfr, cfr(B) and poxtA genes encoding linezolid resistance in enterococci from whole-genome sequences.

Journal of Antimicrobial Chemotherapy, 2019
OBJECTIVES In enterococci, resistance to linezolid is often mediated by mutations in the V domain of the 23S rRNA gene (G2576T or G2505A). Furthermore, four genes [optrA, cfr, cfr(B) and poxtA] encode linezolid resistance in enterococci.
H. Hasman, P. L. C. Clausen, H. Kaya, F. Hansen, J. Knudsen, Mikala Wang, B. Holzknecht, Jurgita Samulioniené, B. Røder, N. Frimodt-Møller, O. Lund, A. Hammerum   +11 more
semanticscholar   +1 more source

Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it

Nature Chemical Biology
The bacterial ribosome is an essential drug target as many clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several ...
Elena V. Aleksandrova, Kelvin J. Y. Wu, Ben I. C. Tresco, E. A. Syroegin, Erin E. Killeavy, S. Balasanyants, M. Svetlov, Steven T. Gregory, G. Atkinson, Andrew G. Myers, Y. Polikanov   +10 more
semanticscholar   +1 more source

Development of a multiplex-PCR to simultaneously detect acquired linezolid resistance genes cfr, optrA and poxtA in enterococci of clinical origin.

Journal of Microbiological Methods, 2019
Linezolid-resistant enterococcus spp. are increasingly recognized by diagnostic laboratories. Resistance can be mediated by the expression of cfr, optrA or poxtA. We developed a multiplex-PCR to simultaneously detect all three genes.
Jennifer K. Bender, Carola Fleige, I. Klare, G. Werner   +3 more
semanticscholar   +1 more source

Model‐based analysis of the sensitivities and diagnostic implications of FFR and CFR under various pathological conditions

International Journal for Numerical Methods in Biomedical Engineering, 2019
Although fractional flow reserve (FFR) and coronary flow reserve (CFR) are both frequently used to assess the functional severity of coronary artery stenosis, discordant results of diagnosis between FFR and CFR in some patient cohorts have been reported.
Xinyang Ge, Youjun Liu, S. Tu, S. Simakov, Y. Vassilevski, F. Liang   +5 more
semanticscholar   +1 more source

Wear behaviour of CFR PEEK articulated against CoCr under varying contact stresses: Low wear of CFR PEEK negated by wear of the CoCr counterface.

Journal of The Mechanical Behavior of Biomedical Materials, 2019
Total hip replacement with metal-on-polymer hip prostheses is the most common treatment for late-stage osteoarthritis. However, the wear debris generated from the polymer acetabular liner remains a problem.
Göksu Kandemir, Simon L. Smith, T. Joyce   +2 more
semanticscholar   +1 more source

A novel cfr-carrying Tn7 transposon derivative characterized in Morganella morganii of swine origin in China

Journal of Antimicrobial Chemotherapy, 2018
OBJECTIVES To characterize the presence and genetic environment of the multiresistance gene cfr in bacterial isolates from a swine farm. METHODS A total of 97 bacterial isolates, recovered from 32 faecal swabs obtained on one farm, were tested for the ...
Yan-Peng Chen, Chang-Wei Lei, Lei Zuo, Ling-Han Kong, Zhuangzhuang Kang, Jinxin Zeng, Xiu-Zhong Zhang, Hong-Ning Wang   +7 more
semanticscholar   +1 more source

CFR

2021
openaire   +1 more source