Results 111 to 120 of about 2,418 (178)
Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model
International Forum of Allergy &Rhinology, Volume 16, Issue 8, Page 788-796, August 2026.ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...
Do‐Yeon Cho +9 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Ceftazidime/avibactam (CAZ‐AVI) is an important therapeutic option for multidrug‐resistant (MDR) Pseudomonas aeruginosa infections; however, hypersensitivity reactions may preclude its use and create significant therapeutic challenges. We report a 21‐year‐old woman with cystic fibrosis and recurrent MDR P.
Zuoren Zhou +6 more
wiley +1 more source
Search for proteins with similarity to the CFTR R domain using an optimized RDBMS solution, mBioSQL
Open Life Sciences, 2006 Hegedűs Tamás, Riordan John
doaj +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims Solid tumors emerge from uncontrolled cell division and interactions with neighboring cells that influence their growth and resistance to therapy. Anti‐cancer drugs are developed to disrupt these processes, but they often damage healthy cells, making treatment difficult to manage safely and effectively. As the global cancer
Mohsin Kamran +3 more
wiley +1 more source
Journal of Extracellular Biology, Volume 5, Issue 8, August 2026.ABSTRACT Chronic antibiotic‐resistant cystic fibrosis (CF) lung infections are the leading cause of death in adults with CF. Despite advances in highly effective modulator therapies, microbial communities persist in the CF lung. The pathogenesis of CF airway infections can be exacerbated by pathogens such as Pseudomonas aeruginosa, which communicates ...
Lily A. Charpentier +10 more
wiley +1 more source
MITF Regulates CFTR Expression to Participate in Myocardial Ischemia–Reperfusion Injury
The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.MITF regulates CFTR expression in MIRI, and disruption of the MITF‐CFTR axis is associated with aggravated injury in cellular and animal models. Restoring CFTR partially mitigates MITF deficiency‐related damage. These findings support the involvement of MITF‐CFTR regulation in MIRI and provide a basis for further mechanistic investigation.
Baoxin Tang +4 more
wiley +1 more source
MedComm, Volume 7, Issue 8, August 2026.Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy +8 more
wiley +1 more source
Prediction of Antimicrobial Resistance in People Living With Cystic Fibrosis Using Machine Learning
MedComm, Volume 7, Issue 8, August 2026.Using routinely collected electronic healthcare record data from patients with cystic fibrosis, machine learning models predicted antimicrobial resistance in sputum cultures before susceptibility results were available. Extreme gradient boosting showed consistent discrimination across five commonly tested antibiotics, with AUCs of 0.75–0.80.
Junrong Jiang +10 more
wiley +1 more source
Pediatric Pulmonology, Volume 61, Issue 8, August 2026.ABSTRACT Background People with cystic fibrosis (CF) are at increased risk of fat‐soluble vitamin (A, D, E, and K) deficiencies secondary to exocrine pancreatic insufficiency (EPI). Estimation of vitamin K deficiency in routine clinical practice is challenging, and no uniform consensus exists due to lack of an accurate clinical test for the evaluation ...
Senthilkumar Sankararaman +7 more
wiley +1 more source
Pediatric Pulmonology, Volume 61, Issue 8, August 2026.ABSTRACT Background Decreased apical bicarbonate transport into the airway surface liquid (ASL) has been associated with decreased ASL pH, which can have adverse respiratory effects. However, the human CF epithelium can normalize ASL pH. Thus, we hypothesized that pH regulatory proteins other than the CFTR could be altered in the CF epithelium ...
Michael D. Davis +9 more
wiley +1 more source