Results 121 to 130 of about 31,972 (221)

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Cell Proliferation, Volume 59, Issue 6, June 2026.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang   +6 more
wiley   +1 more source

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Dysfunction in Human Diseases: Molecular Mechanisms and Pathophysiological Implications. [PDF]

Cells
Rahman MS, Daira M.
europepmc   +1 more source

Monosodium glutamate‐mediated Ca2+‐dependent intestinal epithelial ion transports in health and IBS‐D in male mice

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short‐circuit current (Isc) in the murine ileum, which was significantly reduced by extracellular Cl−, Na+, and Ca2 ...
Yunxian Wang, Fenglan Chu, Yanhua Gong, Ruihong Guo, Hui Dong   +4 more
wiley   +1 more source

Functional Rescue of CFTR-Dependent Transport in a Pancreatic Ductal Epithelial Cell Model: The Impact of Pharmacological Modulation and Inflammation. [PDF]

Int J Mol Sci
Ludovico A, Battistini M, Baroni D.
europepmc   +1 more source

Polyglutamine-Expanded Ataxin-3 Accelerates CFTR Degradation Through K63-Linked Ubiquitination to Exacerbate Microglial Inflammation. [PDF]

ASN Neuro
Wang Z, Fan X, Bai B, Song M, Shi Y, Zhao Y, Xie P, Shi T, He C, Hu Y, Wu Q, Hou X.   +11 more
europepmc   +1 more source

Toward Precision Electrochemical Sensing of CFTR Function in Cystic Fibrosis Models. [PDF]

Anal Chem
Miglione A, Blaconà G, Singh S, Cicero SL, Fuso A, Cimino G, Eramo A, Malapelle U, Lucarelli M, Cinti S.   +9 more
europepmc   +1 more source

Spectrum and Classification of CFTR and ADGRG2 Variants in Chinese Patients With Isolated CAVD: A Large Cohort Study and Risk Assessment of CFTR Variant Carriage in Couples. [PDF]

Hum Mutat
Yuan P, Liang Z, Zhou L, Ji X, Wang S, Zhang J, Li J, Xie S, Li Y, Yalikun T, Sun Q, Chen H.   +11 more
europepmc   +1 more source

Decreased pulmonary exacerbations and lower intravenous antibiotic usage following vanzacaftor/tezacaftor/deutivacaftor treatment in people with cystic fibrosis with <i>F508del</i>-minimal function genotypes. [PDF]

Eur Respir J
Horsley A, Arteaga-Solis E, Keating C, Mall MA, Ramsey B, Nair N, Thorat T, Sosnay P.   +7 more
europepmc   +1 more source

Red blood cell deformability as a mechanobiological marker of CFTR dysfunction in cystic fibrosis. [PDF]

iScience
Pero E, Tomaiuolo G, Villella VR, Esposito S, Vetrone MA, Panarelli A, Castaldo A, Sepe A, Andolfo I, Tosco A, Castaldo G, Raia V, Guido S.   +12 more
europepmc   +1 more source

Predictive capacity of paediatric nasal epithelial cells in sequential CFTR modulator therapy. [PDF]

Thorax
Fawcett LK, Chew ZA, Schneider-Futschik EK, Allan KM, Patel HR, Jaffe A, Waters S.   +6 more
europepmc   +1 more source