Results 111 to 120 of about 1,231,622 (330)

Glutathione in Cancer Cell Death [PDF]

, 2011
Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation
Ames, Angel L. Ortega, Arai, Armstrong, Armstrong, Arrick, Arrigo, Azad, Baguley, Baines, Balendiran, Ballatori, Beatrice, Bedikian, Benlloch, Benlloch, Bignold, Biswas, Borst, Boveris, Brdiczka, Brosnan, Bump, Burcham, Calvert, Carrascosa, Carretero, Carretero, Cazanave, Chanas, Chen, Chen, Cheung, Circu, Cole, Conway, Costantini, Costantini, Crook, D'Alessio, Dalton, Dalton, Dang, de Bruin, DeBerardinis, DeGraff, Depeille, Dethmers, Dias, Dickinson, Ekshyyan, Erickson, Estrela, Estrela, Federico, Franco, Franco, Franco, Franco, Friesen, Fulda, Gadsby, Gatti, Gjertsen, Gleave, Gogvadze, Goossens, Gottesman, Guha, Guha, Halestrap, Hall, Hall, Halliwell, Halliwell, Hanigan, Hansen, Hara, Harper, Hayes, Hidalgo, Higuchi, Higuchi, Hochwald, Honda, Ischiropoulos, Janssen-Heininger, Jones, Jose M. Estrela, Kang, Kensler, Keppler, Klaassen, Klasa, Klimberg, Klimberg, Klionsky, Kokoszka, Kowaltowski, Krauskopf, Krebs, Kretz-Remy, Kroemer, Kroemer, Kuhn, Kuo, Kuranaga, Lai, Lee, Leslie, Leslie, Levine, Linsdell, Loe, Loe, Lopes de Menezes, Lorico, Loschen, Lu, Lu, Maher, McDonald, Medina, Meister, Meister, Melis, Mena, Mena, Mieyal, Mistry, Mitchell, Miyake, Morales, Moreira, Morito, Moscow, Nguyen, Obrador, Obrador, Obrador, Ortega, Ortega, Paget, Park, Parmentier, Pastor, Pennington, Petronilli, Priego, Rahman, Rappa, Rebrin, Reisman, Salvador Mena, Savarese, Scherz-Shouval, Schneider, Shacter, Son, Song, Stole, Suthanthiran, Szabo, Terasaki, Terradez, Tormos, Troyano, Um, Usatyuk, Valko, Versantvoort, Wang, Warburg, Wijnholds, Wild, Wise, Wise, Yao, Yuan, Zaman, Zangemeister-Wittke, Zhang, Zhou, Ziegler, Zong   +184 more
core   +2 more sources

ENaC inhibition in cystic fibrosis: potential role in the new era of CFTR modulator therapies

European Respiratory Journal, 2020
Small-molecule cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs for cystic fibrosis are the first therapies since the disease was initially described by Fanconi et al.
M. Mall
semanticscholar   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency [PDF]

, 2005
Affiliation: CHU-Sainte-Justine, Université de MontréalTransport mechanisms, whereby alimentary lipids are digested and packaged into small emulsion particles that enter intestinal cells to be translocated to the plasma in the form of chylomicrons, are ...
Drouin, Éric, Levy, Emile, Marcil, Valérie, Peretti, Noël   +3 more
core   +2 more sources

Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis [PDF]

, 2022
Kevin W Southern, Carlo Castellani, Elise Lammertyn, Alan R Smyth, Donald R. VanDevanter, Silke van Koningsbruggen‐Rietschel, Jürg Barben, Amanda Bevan, Edwin J. Brokaar, Sarah Collins, Gary Connett, T. Daniels, Jane C. Davies, Dimitri Declercq, Silvia Gärtner, Andrea Gramegna, Naomi Hamilton, Jenny Hauser, N. Kashirskaya, Laurence Kessler, J. Lowdon, Halyna Makukh, Clémence Martin, Lisa Morrison, D. Nazareth, Jacquelien Noordhoek, Ciarán O’Neill, E. Owen, H. Oxley, Karen S. Raraigh, Caroline Raynal, Karen A. Robinson, Jobst Roehmel, Carsten Schwarz, Isabelle Sermet‐Gaudelus, Michal Shteinberg, Ian Sinha, Constance Takawira, Peter van Mourik, Marieke Verkleij, Michael D Waller, Alistair Duff   +41 more
openalex   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Rescue of Murine F508del CFTR Activity in Native Intestine by Low Temperature and Proteasome Inhibitors [PDF]

, 2012
Most patients with Cystic Fibrosis (CF) carry at least one allele with the F508del mutation, resulting in a CFTR chloride channel protein with a processing, gating and stability defect, but with substantial residual activity when correctly sorted to the ...
Bot, A.G. (Alice), Jonge, H.R. (Hugo) de, Jorna, H. (Huub), Scholte, B.J. (Bob), Wilke, M. (Martina)   +4 more
core   +4 more sources

Effect of CFTR Modulators on Oxidative Stress and Autophagy in Non-CFTR-Expressing Cells [PDF]

International Journal of Molecular Sciences
The triple combination therapy for cystic fibrosis (CF), including elexacaftor, tezacaftor and ivacaftor (ETI or Trikafta), has been shown to improve lung function and reduce pulmonary exacerbations, thereby enhancing the quality of life for most CF patients.
Filippo Scialò, Gustavo Cernera, Lorenza Polise, Giuseppe Castaldo, Felice Amato, Valeria Rachela Villella   +5 more
openalex   +4 more sources

3D Automated Segmentation of Bronchial Abnormalities on Ultrashort Echo Time MRI: A Quantitative MR Outcome in Cystic Fibrosis

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Cystic fibrosis (CF) monitoring relies on computed tomography (CT), but ultra‐short echo time MRI (UTE‐MRI) offers a radiation‐free alternative. However, its clinical adoption is hindered by the laborious and subjective manual analysis, which prevents standardized quantification of bronchial abnormalities.
Amel Imene Hadj Bouzid, Ilyes Benlala, Baudouin Denis de Senneville, Fabien Baldacci, Julie Macey, Wadie Benhassen, Pan Su, Stephanie Bui, Maeva Zysman, Aurelien Bustin, Patrick Berger, Gael Dournes   +11 more
wiley   +1 more source

Long-term culture of intestinal cell progenitors: an overview of their development, application, and associated technologies [PDF]

, 2016
Purpose of Review Long-term culture of adult progenitor cells in 3D is a recently emerging technology that inhabits the space between 2D cell lines and organ slice culture.
Hollins, Andrew John, Parry, Lee
core   +1 more source