Results 211 to 220 of about 1,231,622 (330)

Beyond the Surface: Novel Therapy Approach for Pancreatitis in the Setting of CFTR Dysfunction

Case Reports in Gastrointestinal Medicine, Volume 2026, Issue 1, 2026.
Objectives Despite cystic fibrosis transmembrane conductance regulator (CFTR) proteins being present throughout the entire body and organ systems, typical presentation of cystic fibrosis (CF) involves lung disease. We report a series of individuals that were referred to our CF clinic for evaluation following a diagnosis of chronic pancreatitis or acute
Brittany A. Wright, Ellie Hodapp, Douglas B. Hornick, Tahuanty A. Peña, Poulami Jha   +4 more
wiley   +1 more source

Current strategies for the long-term assessment, monitoring, and management of cystic fibrosis patients treated with CFTR modulator therapy [PDF]

, 2016
J.S. Elborn, Jane C. Davies, Marcus Mall, Patrick A. Flume, Barry J. Plant   +4 more
openalex   +1 more source

Greenness, Whiteness, and Blueness Assessment With a Novel and Fully Validated HPLC Method for Simultaneous Analysis of Lumacaftor and Ivacaftor in Sweat

International Journal of Analytical Chemistry, Volume 2026, Issue 1, 2026.
Sweat is an alternative biological fluid to plasma, urine, hair, and saliva, and it is promising for various pharmaceutical research types. Excessive sweating is one of the symptoms of cystic fibrosis, a hereditary disease. In this study, an easy, simple, applicable, and economical HPLC method was proposed for sweat analysis of the lumacaftor/ivacaftor
Serkan Levent, Abeer Elriş, Saniye Özcan, Nafiz Öncü Can, Deepali   +4 more
wiley   +1 more source

Effect of cystic fibrosis transmembrane conductance regulator modulators and dedicated cystic fibrosis gastrointestinal clinic visits on the incidence of distal intestinal obstructive syndrome in persons with cystic fibrosis.

PLoS ONE
BackgroundGastrointestinal (GI) complications are the second most common disorders in persons with cystic fibrosis (PwCF). There is limited data on how having a dedicated CF-GI clinic and cystic fibrosis transmembrane conductance regulator (CFTR ...
Nicha Wongjarupong, Malique F Delbrune, Jameel Alp, Daphne M Moutsoglou, Talia Wiggen, Ashley Benner, Joanne L Billings, Jordan M Dunitz, Sarah J Schwarzenberg, Baharak Moshiree, Shahnaz Sultan   +10 more
doaj   +1 more source

Aldose reductase deficiency protects the retinal neurons in a mouse model of retinopathy of prematurity [PDF]

, 2012
Poster Presentation: P64PURPOSE: Retinopathy of prematurity (ROP) is a common retinal disease occurred in premature babies. It is found to be related to oxidative stress while dysfunction of the neural retina has also been documented.
Chung, SK, Fu, Z, Li, SY, Lo, ACY, Wong, D   +4 more
core  

Pharmacokinetic variability of CFTR modulators from standard and alternative regimens [PDF]

Natalie R. Rose, A. Chalamalla, Bryan Garcia, Stefanie Krick, Jonathan Bergeron, Hossein Sadeghi, D. Schellhase, Kevin J. Ryan, Alexander E. Dowell, Edward P. Acosta, Jennifer S. Guimbellot   +10 more
openalex   +1 more source

87: Characterization of pediatric and adolescent patients at risk for adverse reactions related to triple combination CFTR modulator therapy

, 2021
Jenna M. Rosano, Marie E. Egan
openalex   +1 more source

From Pathophysiology to Treatment: Contemporary Approaches to CFRD in the Pediatric and Adolescent Population

Pediatric Diabetes, Volume 2026, Issue 1, 2026.
Cystic fibrosis‐related diabetes (CFRD) is the most prevalent nonrespiratory complication of cystic fibrosis (CF), with its prominence growing as survival rates improve due to advances in CFTR modulator therapies. Its prevalence increases with age, affecting nearly 50% of patients with CF (PwCF) over 30 years old.
Dogus Vuralli, Andrea Scaramuzza
wiley   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source

Optimizing CFTR modulator therapy management for cystic fibrosis through the ReX platform. [PDF]

Front Pediatr, 2023
Yaacoby-Bianu K, Cohen-Cymberknoh M, Shoseyov D, Lavi T, Ostrovski A, Shteinberg M, Livnat G.   +6 more
europepmc   +1 more source