Results 111 to 120 of about 1,208,918 (256)

Selective inhibition of intestinal guanosine 3,5-cyclic monophosphate signaling by small-molecule protein kinase inhibitors [PDF]

, 2018
The guanosine 3,5-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) serine/threonine kinase relays signaling through guanylyl cyclase C (GCC) to control intestinal fluid homeostasis.
Bijvelds, M.J.C. (Marcel), Bongartz, J.-P. (Jean-Pierre), Donck, L.V. (Luc Ver), Hellemans, A. (Ann), Jonge, H.R. (Hugo) de, Maeyer, J.H. (Joris) de, Meijsen, K.F. (Kelly F.), Nieuwenhuijze, N.D.A. (Natascha D.A.), Schuurkes, J.A.J. (Jan), Smans, K. (Karine), Tresadern, G. (Gary)   +10 more
core   +2 more sources

Real-World Safety of CFTR Modulators in the Treatment of Cystic Fibrosis: A Systematic Review

Journal of Clinical Medicine, 2020
Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies target the underlying cause of cystic fibrosis (CF), and are generally well-tolerated; however, real-world studies indicate the frequency of discontinuation and adverse events
Renée Dagenais, Victoria C H Su, B. Quon   +2 more
semanticscholar   +1 more source

Obstetric and Neonatal Outcomes in Pregnancies From a Dedicated Cystic Fibrosis‐Maternal Health Service: A Retrospective Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective A comprehensive review of maternal, obstetric and neonatal outcomes in pregnancies in females with cystic fibrosis (fwCF) following the introduction of Elexacaftor/Tezacaftor/Ivacaftor (ETI) therapy in a novel, dedicated CF‐Maternal Health service.
Rebecca Scott, Amy Downes, Ladina Weitnauer, Rebecca Dobra, Natasha Singh, Rachel Robinson, Emily Diable, Saraha Collins, Elaine Bowman, Thomas Tobin, Andrew Jones, Nicholas Simmonds, Imogen Felton   +12 more
wiley   +1 more source

Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease

npj Genomic Medicine, 2022
Over 400 variants in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) are CF-causing. CFTR modulators target variants to improve lung function, but marked variability in response exists and current therapies do not address all CF ...
Jiafen Gong, Gengming He, Cheng Wang, Claire Bartlett, Naim Panjwani, Scott Mastromatteo, Fan Lin, Katherine Keenan, Julie Avolio, Anat Halevy, Michelle Shaw, Mohsen Esmaeili, Guillaume Côté-Maurais, Damien Adam, Stéphanie Bégin, Candice Bjornson, Mark Chilvers, Joe Reisman, April Price, Michael Parkins, Richard van Wylick, Yves Berthiaume, Lara Bilodeau, Dimas Mateos-Corral, Daniel Hughes, Mary J. Smith, Nancy Morrison, Janna Brusky, Elizabeth Tullis, Anne L. Stephenson, Bradley S. Quon, Pearce Wilcox, Winnie M. Leung, Melinda Solomon, Lei Sun, Emmanuelle Brochiero, Theo J. Moraes, Tanja Gonska, Felix Ratjen, Johanna M. Rommens, Lisa J. Strug   +40 more
doaj   +1 more source

Ion channels: structural basis for function and disease. [PDF]

, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

Fungal‐Driven Airways Dis‐Immunity From Asthma to Allergic Bronchopulmonary Aspergillosis: Dissecting Similarities and Differences

Allergy, EarlyView.
ABSTRACT Severe asthma and allergic bronchopulmonary aspergillosis (ABPA) do not rarely coexist and share several similarities in terms of pathobiological background, together with overlapping clinical manifestations, misleading the correct diagnosis. Within that scenario, severe asthma with fungal sensitization (SAFS) further complicates the correct ...
Marco Caminati, Isabella Annesi‐Maesano, Wojciech Feleszko, Giuseppe Guida, Christer Janson, Shadi Hägg, Andrei Malinovschi, Luciana Tanno, Joana Vitte, Francesca Ambrosani, Matteo Maule   +10 more
wiley   +1 more source

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

Journal of Experimental Pharmacology, 2021
Madalena C Pinto,1,* Iris AL Silva,1,* Miriam F Figueira,2 Margarida D Amaral,1 Miquéias Lopes-Pacheco1,* 1Biosystems & Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisboa, Lisboa, Portugal; 2Marsico Lung ...
Pinto MC, Silva IAL, Figueira MF, Amaral MD, Lopes-Pacheco M   +4 more
doaj  

Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters. [PDF]

, 2015
The ABC (ATP Binding Cassette) transporter protein superfamily comprises a large number of ubiquitous and functionally versatile proteins conserved from archaea to humans.
Csermely, Péter, Gangal R,, Gyimesi, Gergely, Gáspár, Merse Előd, Hegedűs, Tamás, Szalay, Kristóf Zsolt   +5 more
core  

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, EarlyView.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Developmental control of CFTR: from bioinformatics to novel therapeutic approaches. [PDF]

, 2015
miRNA-binding blocker oligonucleotides offer an appealing option for developing tools to correct CFTR function http://ow.ly ...
Greene, Catherine M, Hartl, Dominik
core   +1 more source