Results 131 to 140 of about 5,816 (202)

Post-approval studies with the CFTR modulators Elexacaftor-Tezacaftor-Ivacaftor. [PDF]

Front Pharmacol, 2023
Tümmler B.
europepmc   +1 more source

CFTR Modulators for the Treatment of Chronic Obstructive Pulmonary Disease: The Jury Is Still Out! [PDF]

Am J Respir Crit Care Med
Regard L, Burgel PR.
europepmc   +1 more source

Clinical pharmacology of CFTR modulators

With the development of cystic fibrosis transmembrane receptor (CFTR) modulating drugs, the landscape in cystic fibrosis (CF) care has changed dramatically. These drugs enable the treatment of the underlying cause of the disease. Although CFTR modulators show an impressive clincal effect at group level in people with CF (pwCF) with specific mutations ...
Meer - van de Grint, Renske van der, Heijerman, H.G.M., Wilms, E.B.   +2 more
openaire   +1 more source

Pseudomonas infections persisting after CFTR modulators are widespread throughout the lungs and drive lung inflammation. [PDF]

Cell Host Microbe
Durfey SL, Kapnadak SG, Pena T, Willmering MM, Godwin JD, Teresi ME, Heltshe SL, Vo AT, Villacreses RA, Aliukonyte I, Boyken L, Stroik MR, Morgan SJ, Wang GM, Betts HL, Zhang S, Goss CH, Clancy JP, Aitken ML, Steele C, Feder AF, Esther CR, Tiddens HAWM, Woods JC, Stoltz DA, Singh PK.   +25 more
europepmc   +1 more source

Modeling Cystic Fibrosis Patient-Specific Responses to CFTR Modulators Using Human Induced Pluripotent Stem Cells. [PDF]

Am J Respir Crit Care Med
Kanagarajah KR, Wu MJM, Lam T, Quach HT, Salih R, Antonio K, Moraes TJ, Ratjen F, Bear CE, Wong AP.   +9 more
europepmc   +1 more source

Comparative efficacy and safety of CFTR modulators for people with cystic fibrosis with phe508del mutation: a systematic review and bayesian network meta-analysis. [PDF]

EClinicalMedicine
Safeer V S M, Behl S, Vaidya PC, Tiwari P, Bharti SK, Nahan N, Kumar Sahu J, Bansal D.   +7 more
europepmc   +1 more source

Improvement of Cystic Fibrosis-Associated Liver Disease in Adults on Long-Term Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators. [PDF]

Life (Basel)
Manioudaki S, Vasilieva L, Geladari E, Mani I, Athanassa Z, Elefsiniotis I, Hadziyannis E, Sevastianos V, Oikonomou A, Theophilou A, Diamantea F, Alexopoulou A.   +11 more
europepmc   +1 more source

Progress of personalized medicine of cystic fibrosis in the times of efficient CFTR modulators. [PDF]

Mol Cell Pediatr
Tümmler B, Pallenberg ST, Dittrich AM, Graeber SY, Naehrlich L, Sommerburg O, Mall MA.   +6 more
europepmc   +1 more source

A new era of cystic fibrosis therapy with CFTR modulators. [PDF]

J Bras Pneumol
Barros LGB, Prestes LM, Fernandes MFGM, Silva-Filho LVRFD, Pinto LA.   +4 more
europepmc   +1 more source

Impact of CFTR Modulators on Longitudinal Cystic Fibrosis Survival and Mortality: Review and Secondary Analysis. [PDF]

Pulm Ther
Rubin JL, McKinnon C, Pedra GG, Morgan DA, Zweig K, Liou TG.   +5 more
europepmc   +1 more source