Results 121 to 130 of about 11,406 (228)

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Cell Proliferation, EarlyView.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang   +6 more
wiley   +1 more source

Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections [PDF]

, 2016
Repeated cycles of infections, caused mainly by Pseudomonas aeruginosa, combined with a robust host immune response and tissue injury, determine the course and outcome of cystic fibrosis (CF) lung disease. As the disease progresses, P.
Bragonzi, Alessandra, Cabrini, Giulio, Cigana, Cristina, De Fino, Ida, Lorè, Nicola Ivan, Nonis, Alessandro, Riva, Camilla, Rossi, Giacomo, Sipione, Barbara, Spagnuolo, Lorenza   +9 more
core   +2 more sources

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, EarlyView.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

Heat-stable enterotoxins of enterotoxigenic Escherichia coli and their impact on host immunity [PDF]

, 2019
Enterotoxigenic Escherichia coli (ETEC) are an important diarrhea-causing pathogen and are regarded as a global threat for humans and farm animals. ETEC possess several virulence factors to infect its host, including colonization factors and enterotoxins.
Cox, Eric, Devriendt, Bert, Luo, Yu, Wang, Haixiu, Zhong, Zifu   +4 more
core   +1 more source

The Role of Nontuberculous Mycobacteria in Patients With Cystic Fibrosis Advanced Lung Disease

Transplant Infectious Disease, EarlyView.
Among 270 cystic fibrosis patients, 20.7% were NTM‐positive and had a lower pre‐transplant risk of death or lung transplantation but higher post‐transplant mortality, with no difference in CLAD incidence. These results suggest NTM infection should not be an absolute contraindication to lung transplantation, though careful individual risk assessment is ...
Shirin Barcikowski, Ribal Bou Mjahed, Oriol Manuel, Macé M. Schuurmans, Adrian Alonso, Zisis Balmpouzis, Jesica Mazza‐Stalder, Angela Koutsokera, Nicolas J. Mueller   +8 more
wiley   +1 more source

CFTR May Modulate AQP9 Functionality in Preeclamptic Placentas

Placenta, 2009
Preeclampsia (PE) is a hypertensive disorder unique to human pregnancy. Although its causes remain unclear, it is known that altered placental villous angiogenesis and a poorly developed fetoplacental vasculature can affect the transport functions of the syncytiotrophoblast (hST).
Castro-Parodi, Mauricio Omar, Levi, Lorena Natalia, Dietrich, Valeria, Zotta, Elsa, Damiano, Alicia Ermelinda   +4 more
openaire   +3 more sources

Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis [PDF]

European Respiratory Review, 2013
Cystic fibrosis (CF) is caused by genetic mutations that affect the cystic fibrosis transmembrane conductance regulator (CFTR) protein. These mutations can impact the synthesis and transfer of the CFTR protein to the apical membrane of epithelial cells ...
Nico Derichs
doaj  

Role of CFTR and ClC-5 in Modulating Vacuolar H+-ATPase Activity in Kidney Proximal Tubule [PDF]

, 2010
Background/Aims: It has been widely accepted that chloride ions moving along chloride channels act to dissipate the electrical gradient established by the electrogenic transport of H+ ions performed by H+-ATPase into subcellular vesicles.
Bezerra, Camila N. A., Carraro-Lacroix, Luciene Regina, Girardi, Adriana C. C., Lessa, Lucilia M. A., Malnic, Gerhard, Morales, Marcelo M., Pessoa, Thaissa D., Souza-Menezes, Jackson   +7 more
core   +1 more source

‘The Hero's journey’: Narratives on the transition to motherhood with cystic fibrosis

British Journal of Health Psychology, Volume 31, Issue 2, May 2026.
Abstract Objectives This study aimed to explore the impact of cystic fibrosis (CF) on the transition to motherhood using a strength‐based narrative approach. It sought to elevate the voices of women with CF and examine how they navigate pregnancy and early motherhood in the context of chronic illness. Design A qualitative narrative study was conducted,
Alena J. Haines, Lynette Mackenzie, Anne Honey, Peter Middleton   +3 more
wiley   +1 more source