Results 131 to 140 of about 11,406 (228)

Epigenetic Alterations Beyond CpG Islands in Periodontitis: In Silico Study of DNA Methylation Data

Clinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objectives To classify differentially methylated CpG sites in periodontitis based on methylation shift direction and location relative to CpG islands. Material and Methods We integrated DNA methylation data from 65 gingival samples (31 periodontitis, 34 healthy) from three GEO datasets.
Koki Yoshida, Gowri Sivaramakrishnan, Farah Asa'ad   +2 more
wiley   +1 more source

Personalised medicine of Cystic fibrosis [PDF]

, 2017
Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia, Universitat de Barcelona, 2017. Tutor: Carlos Julián Ciudad i Gómez[en] The European commission defines personalised medicine as a medical approach that uses molecular insights into health and ...
Cabré Juan, Antoni
core  

3D Automated Segmentation of Bronchial Abnormalities on Ultrashort Echo Time MRI: A Quantitative MR Outcome in Cystic Fibrosis

Journal of Magnetic Resonance Imaging, Volume 63, Issue 4, Page 1190-1200, April 2026.
ABSTRACT Background Cystic fibrosis (CF) monitoring relies on computed tomography (CT), but ultra‐short echo time MRI (UTE‐MRI) offers a radiation‐free alternative. However, its clinical adoption is hindered by the laborious and subjective manual analysis, which prevents standardized quantification of bronchial abnormalities.
Amel Imene Hadj Bouzid, Ilyes Benlala, Baudouin Denis de Senneville, Fabien Baldacci, Julie Macey, Wadie Benhassen, Pan Su, Stephanie Bui, Maeva Zysman, Aurelien Bustin, Patrick Berger, Gael Dournes   +11 more
wiley   +1 more source

Transforming Care in Cystic Fibrosis: The Long‐Term Impact of Quality Improvement Projects on Clinical Outcomes

Pediatric Pulmonology, Volume 61, Issue 4, April 2026.
ABSTRACT Objective This study aimed to evaluate 5‐year outcomes of a structured quality improvement (QI) program implemented as part of the standard of care at our CF center, focusing on changes in body mass index (BMI) and forced expiratory volume in 1 s (FEV₁) in pwCF followed at our institution.
S. Karabulut, M. Yuksel Kalyoncu, M. Selcuk Balcı, N. Metin Cakar, C. A. Yıldız, B. Uzunoglu, G. Tastan, D. Kocaman, C. Yılmaz Yeğit, A. P. Ergenekon, E. Erdem Eralp, Y. Gokdemir, F. Karakoc, S. Z. Nasr, B. Karadag   +14 more
wiley   +1 more source

Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. [PDF]

, 2019
Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions ...
Akiba, Yasutada, Iwasaki, Mari, Kaunitz, Jonathan D   +2 more
core  

Clinical pharmacology of CFTR modulators

With the development of cystic fibrosis transmembrane receptor (CFTR) modulating drugs, the landscape in cystic fibrosis (CF) care has changed dramatically. These drugs enable the treatment of the underlying cause of the disease. Although CFTR modulators show an impressive clincal effect at group level in people with CF (pwCF) with specific mutations ...
openaire   +2 more sources

Inflammatory response in CF airway epithelial cells: a comparative study of modulators and wild-type CFTR rescue

Frontiers in Pharmacology
The combination of pharmacological modulators such as lumacaftor, tezacaftor, and elexacaftor restore CFTR activity at the plasma membrane and improve lung function in patients carrying CFTR mutations such as F508del, their effects on inflammation are ...
Amal Kouadri, Amal Kouadri, Amal Kouadri, Camille Lyko, Camille Lyko, Camille Lyko, Carine El Hajjar, Carine El Hajjar, Carine El Hajjar, Johanna Cormenier, Johanna Cormenier, Johanna Cormenier, Kevin Kevin Gemy, Kevin Kevin Gemy, Kevin Kevin Gemy, Nadia Alfaidy, Nadia Alfaidy, Nadia Alfaidy, Mohamed Benharouga, Mohamed Benharouga, Mohamed Benharouga   +20 more
doaj   +1 more source

Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases

, 2008
Cellular networks undergo rearrangements during stress and diseases. In un-stressed state the yeast protein-protein interaction network (interactome) is highly compact, and the centrally organized modules have a large overlap.
Albanese, Albert, Almaas, Arita, Barabasi, Barabasi, Batada, Batada, Batagelj, Bertin, Bobula, Colizza, Csermely, Csermely, Csermely, Csermely, Derenyi, Ekman, Gasch, Goldberger, Guimerá, Han, Kim, Komurov, Korcsmaros, Korcsmáros, Lewandowska, Linding, Luscombe, Macario, Maslov, McAuley, McClellan, Ng, Palla, Papp, Pál, Ravasz, Rutherford, Sales-Pardo, Shorter, Song, Soti, Soti, Soti, Szabadkai, Szalay, Tanaka, Taxis, Vigh, Wang, Watts, Xu, Yu, Zhu   +54 more
core   +2 more sources

Novel CFTR Modulators for Treating Cystic Fibrosis [PDF]

ACS Medicinal Chemistry Letters, 2021
openaire   +3 more sources

Cystic Fibrosis: Treatment with CFTR Modulators

, 2023
CFTR modulators have been a groundbreaking new invention starting with the approval of the CFTR corrector Ivacaftor in 2012. Nowadays, up to 90% of CF patients have the potential ability to get treated by an appropriate CFTR modulator. Ivacaftor showed significant improvement in the treatment of CF patients with gating mutations, especially in G551D ...
openaire   +2 more sources