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Molecular isoforms of chicken growth hormone (cGH): Different bioactivities of cGH charge variants
General and Comparative Endocrinology, 1990It has been suggested that the functional diversity of growth hormone (GH) is related to its molecular complexity. Here we report a characterization of charge and mass variants of chicken growth hormone (cGH) through a variety of electrophoretic systems [nondenaturing (ND-PAGE), denaturing (SDS-PAGE), under reducing and nonreducing conditions ...
C, Arámburo +4 more
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2013
To study genomic imbalances potentially involved in disease development and/or progression of childhood MDS, array-based comparative genomic hybridization (aCGH) is a helpful tool. Copy number alterations (CNA) of subtle chromosomal regions containing potential candidate genes, e.g., TP53 or RUNX1 can be detected.
Marcel, Tauscher +2 more
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To study genomic imbalances potentially involved in disease development and/or progression of childhood MDS, array-based comparative genomic hybridization (aCGH) is a helpful tool. Copy number alterations (CNA) of subtle chromosomal regions containing potential candidate genes, e.g., TP53 or RUNX1 can be detected.
Marcel, Tauscher +2 more
openaire +2 more sources
CGH Protocols: Chronic Lymphocytic Leukemia
2013Array-based comparative genomic hybridization (aCGH) is a powerful assay to identify copy number abnormalities underlying the pathogenesis of cancer. aCGH has become the gold standard for whole genome copy number analysis in medium and large cohorts in clinical and research laboratories.
Esteban, Braggio +2 more
openaire +2 more sources
2013
Alterations in the copy number of the cancer genome are frequently observed in brain tumors especially gliomas. Some pertinent examples include amplification of the EGFR locus in chromosome 7p and loss of the PTEN locus in 10q in glioblastoma. Meningiomas are often associated with loss of the NF2 locus in 22q.
Gayatry, Mohapatra +2 more
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Alterations in the copy number of the cancer genome are frequently observed in brain tumors especially gliomas. Some pertinent examples include amplification of the EGFR locus in chromosome 7p and loss of the PTEN locus in 10q in glioblastoma. Meningiomas are often associated with loss of the NF2 locus in 22q.
Gayatry, Mohapatra +2 more
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Prenatal Diagnosis Using Array CGH
2008Microarray-based comparative genomic hybridization (array CGH) is a fast and high-resolution approach to the diagnosis of a large number of genetic syndromes associated with loss or gain of the human genome. This technology has proven to be useful in several clinical settings, including postnatal diagnosis of mental retardation, developmental delay ...
Catherine D, Kashork +2 more
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Archives of disease in childhood - Education & practice edition, 2013
Array comparative genomic hybridisation (CGH), a new cytogenetic technology, is a new diagnostic tool for genetic disorders. A 2-year-old girl was seen in clinic because of concerns regarding her development. Her parents say that she has always been a bit floppy and had difficulties feeding as a baby. She is not yet walking, but bottom-shuffles.
Shereen, Tadros +2 more
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Array comparative genomic hybridisation (CGH), a new cytogenetic technology, is a new diagnostic tool for genetic disorders. A 2-year-old girl was seen in clinic because of concerns regarding her development. Her parents say that she has always been a bit floppy and had difficulties feeding as a baby. She is not yet walking, but bottom-shuffles.
Shereen, Tadros +2 more
openaire +2 more sources
Comparative Genomic Hybridisation (CGH)
2011CGH is a technique used to identify unbalanced chromosomal aberrations in solid tumors. It provides a global overview of chromosomal gains and losses. Two variants are used in research and diagnostics, chromosomal CGH and array CGH. The major difference is within the detection system.
Hannelore Kothmaier +3 more
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2021
The aim of this research was to conduct the comparative analysis of the karyotype of new human stem cell line 4BL at different stages of cultivation in vitro. Methods. The array CGH Oxford Gene Technology was used. Results. At the 120, 160 and 205 passages such the same aberrations were revealed: duplications of 2q31.1-q33.1, 10 q22.1-q22.2 and q24.2 ...
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The aim of this research was to conduct the comparative analysis of the karyotype of new human stem cell line 4BL at different stages of cultivation in vitro. Methods. The array CGH Oxford Gene Technology was used. Results. At the 120, 160 and 205 passages such the same aberrations were revealed: duplications of 2q31.1-q33.1, 10 q22.1-q22.2 and q24.2 ...
openaire +1 more source
2009
This excerpt gives a succinct explanation of computer-generated holograms Design Guidelines.
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This excerpt gives a succinct explanation of computer-generated holograms Design Guidelines.
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