Results 101 to 110 of about 70,973 (282)
cGMP modulates spike responses of retinal ganglion cells
, 2001 Certain ganglion cells in the mammalian retina are known to express a cGMP-gated cation channel. We found that a cGMP-gated current modulates spike responses of the ganglion cells in mammalian retinal slice ...
Via Cgmp-Gated Current
core
Biophysical Techniques for Detection of cAMP and cGMP in Living Cells
, 2013 Cyclic nucleotides cAMP and cGMP are ubiquitous second messengers which regulate myriads of functions in virtually all eukaryotic cells. Their intracellular effects are often mediated via discrete subcellular signaling microdomains.
Nikolaev, Viacheslav O. +3 more
core +1 more source
, 2021 Intracellular cGMP levels following ANP treatment for 30, 60, and 90 min in H295R human adrenocortical cells. A significant increase in cGMP was observed only with 50 pg/mL at 60min. Error bars represent standard errors. (*P < 0.05 compared to control; Y
Gulay Tegin (11725537) +4 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei +2 more
wiley +1 more source
Orphanet Journal of Rare Diseases, 2019 In phenylketonuria, casein glycomacropeptide (CGMP) requires modification with the addition of some essential and semi essential amino acids to ensure suitability as a protein substitute.
A. Daly +9 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov +10 more
wiley +1 more source
Molecular and functional compartmentation of cGMP in the heart
, 2020 Cyclic GMP (cGMP) is a second messenger that regulate cardiovascular functions and therapies that increase cGMP shows beneficial effects. However, the mechanisms behind some of these effects in the heart are elusive.
Calamera, Gaia
core
Sickle Cell Disease: Historical Overview and Current Therapies
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde +4 more
wiley +1 more source
Research progress of phosphodiesterase 5 in heart failure [PDF]
Jichu yixue yu linchuangPhosphodiesterase 5 (PDE5), a cyclic guanosine monophosphate (cGMP)-specific hydrolase, is targets cGMP produced by soluble guanosine cyclase (sGC) that is activated by nitric oxide (NO). It catalyzes the hydrolysis of the phosphodiester bond in cGMP and
YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei
doaj +1 more source
Specificity of cGMP binding to a purified cGMP-stimulated phosphodiesterase from bovine adrenal tissue. [PDF]
, 1985 The binding of [3H]cGMP (guanosine 3',5'-monophosphate) to purified bovine adrenal cGMP-stimulated phosphodiesterase was measured by Millipore filtration on cellulose ester filter.
Haastert, Peter J.M. van, +9 more
core +1 more source