Results 81 to 90 of about 70,973 (282)

In vitro expression of c cyclic guanosine monophosphate (cGMP) in the nerve fiber layer and inner nuclear layer of a healthy or detached retina

, 2011
Copyright information:Taken from "Cyclic GMP in the pig vitreous and retina after experimental retinal detachment"Molecular Vision 2008;14():255-261.Published online 04 Feb 2008PMCID:PMC2254957.
Marijke A.M. Lemmens (87953), Aize Kijlstra (52532), Ellen C. La Heij (87952), Roselie M.H. Diederen (87951), Fred Hendrikse (87955), Jan de Vente (87954)   +5 more
core   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Studies of the Molecular Mechanism of Discrimination between cGMP and cAMP in the Allosteric Sites of the cGMP-binding cGMP-specific Phosphodiesterase (PDE5) [PDF]

Journal of Biological Chemistry, 1999
The regulatory domain of the cGMP-binding cGMP-specific 3':5'-cyclic nucleotide phosphodiesterase (PDE5) contains two homologous segments of amino acid sequence that encode allosteric cyclic nucleotide-binding sites, referred to as site a and site b, which are highly selective for cGMP over cAMP.
I V, Turko, S H, Francis, J D, Corbin
openaire   +2 more sources

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide

Frontiers in Neuroscience, 2019
PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders.
John F. Harms, Frank S. Menniti, Christopher J. Schmidt   +2 more
doaj   +1 more source

Effect of retinal detachment on vitreous cyclic guanosine monophosphate (cGMP)(pmol/ml) levels

, 2011
Copyright information:Taken from "Cyclic GMP in the pig vitreous and retina after experimental retinal detachment"Molecular Vision 2008;14():255-261.Published online 04 Feb 2008PMCID:PMC2254957.
Marijke A.M. Lemmens (87953), Aize Kijlstra (52532), Ellen C. La Heij (87952), Roselie M.H. Diederen (87951), Fred Hendrikse (87955), Jan de Vente (87954)   +5 more
core   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Frontiers in Molecular Neuroscience, 2014
Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation and release of cyclic guanosine-3’,5’-monophosphate (
Gerhard eHannig, Boris eTchernychev, Caroline B Kurtz, Alexander P Bryant, Mark G Currie, Inmaculada eSilos-Santiago   +5 more
doaj   +1 more source

Donkwa Enriched With Goron‐Tula (Azanza garckeana) Modulates Sexual Behavior and Activity of Enzymes Linked With Erectile Dysfunction in High‐Fat Diets/ Streptozotocin‐Induced (STZ/HFD) Diabetic Rats

Food Chemistry International, EarlyView.
(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi, O. S. Ijarotimi, A. A. Badejo   +2 more
wiley   +1 more source

Real-time imaging of cGMP signaling shows pronounced differences between glomerular endothelial cells and podocytes

Scientific Reports
Recent clinical trials of drugs enhancing cyclic guanosine monophosphate (cGMP) signaling for cardiovascular diseases have renewed interest in cGMP biology within the kidney.
Nelli Rutkowski, Frederik Görlitz, Eva Wiesner, Julia Binz-Lotter, Susanne Feil, Robert Feil, Thomas Benzing, Matthias J. Hackl   +7 more
doaj   +1 more source