Results 71 to 80 of about 77,168 (243)

Nitric oxide-mediated modulation of the murine locomotor network [PDF]

, 2014
CD was supported by a BBSRC studentshipSpinal motor control networks are regulated by neuromodulatory systems to allow adaptability of movements. The present study aimed to elucidate the role of nitric oxide (NO) in the modulation of mammalian spinal ...
Miles, Gareth Brian, Foster, Joshua David, Sillar, Keith Thomas, Dunford, Catherine   +3 more
core   +1 more source

Uncatalyzed Guanosine Phosphorylation under Potentially Prebiotic Conditions

Chemistry – A European Journal, EarlyView.
Pyrophosphate acts as phosphorylating agent of guanosine under simple wet‐dry cycles without condensing agent and inorganic catalysts to afford cyclic guanosine monophosphate derivatives useful for oligomerization in prebiotic processes. ABSTRACT The phosphorylation of nucleosides and their subsequent polymerization are key issues in the study of the ...
Martina Proietti, Bruno Mattia Bizzarri, Elisa De Marchi, Alessandra Giorgi, Raffaele Saladino, Giovanna Costanzo   +5 more
wiley   +1 more source

Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)

Retrovirology, 2007
The effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP analogues on transcriptional activity and replication of human immunodeficiency virus type 1 (HIV-1) was investigated.
Jeang Kuan-Teh, Yedavalli Venkat RK, Lee Jia   +2 more
doaj   +1 more source

In vitro expression of c cyclic guanosine monophosphate (cGMP) in the nerve fiber layer and inner nuclear layer of a healthy or detached retina

, 2011
Copyright information:Taken from "Cyclic GMP in the pig vitreous and retina after experimental retinal detachment"Molecular Vision 2008;14():255-261.Published online 04 Feb 2008PMCID:PMC2254957.
Marijke A.M. Lemmens (87953), Aize Kijlstra (52532), Ellen C. La Heij (87952), Roselie M.H. Diederen (87951), Fred Hendrikse (87955), Jan de Vente (87954)   +5 more
core   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Advances and Techniques to Measure cGMP in Intact Cardiomyocytes

, 2013
Förster resonance energy transfer (FRET)-based biosensors are powerful tools for real-time monitoring of signaling events in intact cells using fluorescence microscopy.
Götz, Konrad R., Krieg, Thomas, Lukowski, Robert, Nikolaev, Viacheslav O.   +3 more
core   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Phosphodiesterase 5 attenuates the vasodilatory response in renovascular hypertension.

PLoS ONE, 2013
NO/cGMP signaling plays an important role in vascular relaxation and regulation of blood pressure. The key enzyme in the cascade, the NO-stimulated cGMP-forming guanylyl cyclase exists in two enzymatically indistinguishable isoforms (NO-GC1, NO-GC2) with
Johannes Stegbauer, Sebastian Friedrich, Sebastian A Potthoff, Kathrin Broekmans, Miriam M Cortese-Krott, Ivo Quack, Lars Christian Rump, Doris Koesling, Evanthia Mergia   +8 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Nitric oxide and central autonomic control of blood pressure: a neuroanatomical study of nitric oxide and cGMP expression in the brain and spinal cord [PDF]

, 2008
Essential hypertension is defined as a chronic elevation of blood pressure of unknown cause. Though a definitive trigger for this change in blood pressure has not been established, there is a strong association with an upregulation of sympathetic output
Powers-Martin, Kellysan
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