Results 51 to 60 of about 77,168 (243)

Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D/bioreactor model [PDF]

, 2013
IntroductionThe present study examined the effect of C-type natriuretic peptide (CNP) and biomechanical signals on anabolic and catabolic activities in chondrocyte/agarose constructs.MethodsNatriuretic peptide (Npr) 2 and 3 expression were compared in ...
Salter, Donald M, Salter, Donald M., Ramachandran, Manoj, Adrian J Hobbs, Hobbs, Adrian J., Ramachandran, M, Moyes, AJ, Amie J Moyes, Peake, Nicholas, Bader, Dan L, Bader, DL, Chowdhury, Tina T., Donald M Salter, Pramod Achan, Bader, Dan L., Peake, N, Su, N, Achan, P, Hobbs, AJ, Salter, DM, Nyan Su, Achan, Pramod, Nicholas Peake, Chowdhury, TT, Moyes, Amie J., Dan L Bader, Tina T Chowdhury, Su, Nyan, Chowdhury, Tina T, Hobbs, Adrian J, Moyes, Amie J, Manoj Ramachandran   +31 more
core   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Continuous use of glycomacropeptide in the nutritional management of patients with phenylketonuria: a clinical perspective

Orphanet Journal of Rare Diseases, 2021
Background In phenylketonuria (PKU), modified casein glycomacropeptide supplements (CGMP-AA) are used as an alternative to the traditional phenylalanine (Phe)-free L-amino acid supplements (L-AA).
Maria João Pena, Alex Pinto, Manuela Ferreira de Almeida, Catarina de Sousa Barbosa, Paula Cristina Ramos, Sara Rocha, Arlindo Guimas, Rosa Ribeiro, Esmeralda Martins, Anabela Bandeira, Cláudia Camila Dias, Anita MacDonald, Nuno Borges, Júlio César Rocha   +13 more
doaj   +1 more source

Table2_Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.xls

, 2022
Myostatin (MSTN) is a primary negative regulator of skeletal muscle mass and causes multiple metabolic changes. However, whether MSTN mutation affects heart morphology and physiology remains unclear.
Chunling Bai (802326), Lin Zhu (192179), Mingjuan Gu (12010988), Li Gao (131516), Lei Yang (102719), Guangpeng Li (312144), Yajie Gao (1685383), Xinyu Zhou (736229)   +7 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration

Neurobiology of Disease, 2019
The nitric oxide – guanylyl cyclase-1 – cyclic guanylate monophosphate (NO-GC-1–cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degeneration of ...
Lauren K. Wareham, Ana C. Dordea, Grigorij Schleifer, Vincent Yao, Annabelle Batten, Fei Fei, Joseph Mertz, Meredith Gregory-Ksander, Louis R. Pasquale, Emmanuel S. Buys, Rebecca M. Sappington   +10 more
doaj   +1 more source

Nitrated Nucleotides: New Players in Signaling Pathways of Reactive Nitrogen and Oxygen Species in Plants

Frontiers in Plant Science, 2020
Nitration of diverse biomolecules, including proteins, lipids and nucleic acid, by reactive nitrogen species represents one of the key mechanisms mediating nitric oxide (NO) biological activity across all types of organisms.
Marek Petřivalský, Lenka Luhová
doaj   +1 more source

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia

Redox Biology, 2021
3′,5′-cyclic guanosine monophosphate (cGMP) is a druggable second messenger regulating cell growth and survival in a plethora of cells and disease states, many of which are associated with hypoxia. For example, in myocardial infarction and heart failure (
Nadja I. Bork, Anna Kuret, Melanie Cruz Santos, Cristina E. Molina, Beate Reiter, Hermann Reichenspurner, Andreas Friebe, Boris V. Skryabin, Timofey S. Rozhdestvensky, Michaela Kuhn, Robert Lukowski, Viacheslav O. Nikolaev   +11 more
doaj   +1 more source

Mechanisms of Activity-dependent Plasticity in Cellular Nitric Oxide-cGMP Signaling [PDF]

, 2009
Cellular responsiveness to nitric oxide (NO) is shaped by past history of NO exposure. The mechanisms behind this plasticity were explored using rat platelets in vitro, specifically to determine the relative contributions made by desensitization of NO ...
Vernon, J, Roy, B, Vernon, J., Garthwaite, J, Roy, B., Halvey, EJ, Garthwaite, J., Halvey, E.J.   +7 more
core   +1 more source