Results 41 to 50 of about 70,973 (282)

DataSheet1_Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.docx

, 2022
Myostatin (MSTN) is a primary negative regulator of skeletal muscle mass and causes multiple metabolic changes. However, whether MSTN mutation affects heart morphology and physiology remains unclear.
Chunling Bai (802326), Lin Zhu (192179), Mingjuan Gu (12010988), Li Gao (131516), Lei Yang (102719), Guangpeng Li (312144), Yajie Gao (1685383), Xinyu Zhou (736229)   +7 more
core   +1 more source

Unresolved mystery of cyclic nucleotide second messengers, periplasmic acid phosphatases and bacterial natural competence

Microbial Cell
We recently characterized the competitive inhibition of cyclic AMP (cAMP) on three periplasmic acid phosphatases, AphAHi, NadNHi, and eP4 (HelHi), in Haemophilus influenzae Rd KW20. This inhibitory effect is vital for orchestrating the nutritional growth
Kristina Kronborg, Yong Everett Zhang
doaj   +1 more source

A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

Nature Communications, 2018
Nitric oxide (NO) inhibits thrombosis in part by stimulating cyclic guanosine monophosphate (cGMP) production and cGMP-dependent protein kinase I (cGKI) activity in platelets. Here, Wen et al.
Lai Wen, Susanne Feil, Markus Wolters, Martin Thunemann, Frank Regler, Kjestine Schmidt, Andreas Friebe, Marcus Olbrich, Harald Langer, Meinrad Gawaz, Cor de Wit, Robert Feil   +11 more
doaj   +1 more source

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case. [PDF]

PLoS Computational Biology, 2016
Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic determinants of cGMP levels in
Farshid S Garmaroudi, Diane E Handy, Yang-Yu Liu, Joseph Loscalzo   +3 more
doaj   +1 more source

Table3_Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.xlsx

, 2022
Myostatin (MSTN) is a primary negative regulator of skeletal muscle mass and causes multiple metabolic changes. However, whether MSTN mutation affects heart morphology and physiology remains unclear.
Chunling Bai (802326), Lin Zhu (192179), Mingjuan Gu (12010988), Li Gao (131516), Lei Yang (102719), Guangpeng Li (312144), Yajie Gao (1685383), Xinyu Zhou (736229)   +7 more
core   +1 more source

Correlative intravital imaging of cGMP signals and vasodilation in mice

Frontiers in Physiology, 2014
Cyclic guanosine monophosphate (cGMP) is an important signaling molecule and drug target in the cardiovascular system. It is well known that stimulation of the vascular nitric oxide (NO)-cGMP pathway results in vasodilation.
Martin eThunemann, Kjestine eSchmidt, Cor eDe Wit, Xiaoxing eHan, Rakesh K Jain, Dai eFukumura, Robert eFeil   +6 more
doaj   +1 more source

Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis. [PDF]

PLoS ONE, 2016
Much attention has been directed to the physiological effects of nitric oxide (NO)-cGMP signaling, but virtually nothing is known about its hematologic effects.
Tohru Ikuta, Hassan Sellak, Nadine Odo, Adekunle D Adekile, Karin M L Gaensler   +4 more
doaj   +1 more source

cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis

, 2009
Background Endothelium-derived nitric oxide plays an important role for the bone marrow microenvironment. Since several important effects of nitric oxide are mediated by cGMP-dependent pathways, we investigated the role of the cGMP downstream effector ...
Feil, Robert, Hofmann, Franz, Alexandra Aicher, Michael E. Mendelsohn, Aicher, Alexandra, Michael E Mendelsohn, Mendelsohn, Michael E., Alexandra Aicher, Heeschen, Christopher, Feil, Susanne, Christopher Heeschen, Stefanie Dimmeler, Dimmeler, Stefanie, Franz Hofmann, Susanne Feil, Robert Feil   +15 more
core   +1 more source

Table1_Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.xls

, 2022
Myostatin (MSTN) is a primary negative regulator of skeletal muscle mass and causes multiple metabolic changes. However, whether MSTN mutation affects heart morphology and physiology remains unclear.
Chunling Bai (802326), Lin Zhu (192179), Mingjuan Gu (12010988), Li Gao (131516), Lei Yang (102719), Guangpeng Li (312144), Yajie Gao (1685383), Xinyu Zhou (736229)   +7 more
core   +1 more source

Table2_Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.xls

, 2022
Myostatin (MSTN) is a primary negative regulator of skeletal muscle mass and causes multiple metabolic changes. However, whether MSTN mutation affects heart morphology and physiology remains unclear.
Chunling Bai (802326), Lin Zhu (192179), Mingjuan Gu (12010988), Li Gao (131516), Lei Yang (102719), Guangpeng Li (312144), Yajie Gao (1685383), Xinyu Zhou (736229)   +7 more
core   +1 more source