Results 31 to 40 of about 70,973 (282)

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation.
Wendy Ying, Di Zhao, Pamela Ouyang, Vinita Subramanya, Dhananjay Vaidya, Chiadi E. Ndumele, Eliseo Guallar, Kavita Sharma, Sanjiv J. Shah, David A. Kass, Ron C. Hoogeveen, Joao A. Lima, Susan R. Heckbert, Christopher R. deFilippi, Wendy S. Post, Erin D. Michos   +15 more
doaj   +1 more source

β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

eLife, 2020
Cardiomyocyte β3-adrenoceptors (β3-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure.
Sophie Schobesberger, Peter T Wright, Claire Poulet, Jose L Sanchez Alonso Mardones, Catherine Mansfield, Andreas Friebe, Sian E Harding, Jean-Luc Balligand, Viacheslav O Nikolaev, Julia Gorelik   +9 more
doaj   +1 more source

The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model.

PLoS ONE, 2022
IntroductionManagement of phenylketonuria (PKU) is mainly achieved through dietary control with limited intake of phenylalanine (Phe) from food, supplemented with low protein (LP) food and a mixture of free synthetic (FS) amino acids (AA) (FSAA).
Kirsten K Ahring, Frederik Dagnæs-Hansen, Annemarie Brüel, Mette Christensen, Erik Jensen, Thomas G Jensen, Mogens Johannsen, Karen S Johansen, Allan M Lund, Jesper G Madsen, Karen Brøndum-Nielsen, Michael Pedersen, Lambert K Sørensen, Mads Kjolby, Lisbeth B Møller   +14 more
doaj   +1 more source

Nitric Oxide-Independent cGMP Efflux in the Striatum of Rats Exposed to Carbon Monoxide as Determined by Microdialysis

Journal of Pharmacological Sciences, 2007
Extracellular cGMP in the striatum of rats exposed to 3000 ppm carbon monoxide (CO) or 8% O2 was decreased during the early period of exposure. Thereafter, extracellular cGMP in rats exposed to CO, but not 8% O2, was transiently increased. A nitric oxide
Shuichi Hara, Toshiji Mukai, Hajime Mizukami, Fumi Kuriiwa, Takashi Watanabe, Takahiko Endo   +5 more
doaj   +1 more source

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]

, 2012
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J., Martina Kurejova, Thomas Kuner, Irmgard Tegeder (179372), Hu, S.J., Kurejova Martina, Bali, K.K., Agarwal, Nitin, Anke Tappe-Theodor, Bali, Kiran Kumar, Polgar Erika, Franz Hofmann (179398), Todd, A.J., Lewin, G., Kuner Thomas, Ceng Luo (179354), Feil, Robert, Jens Schlossmann, Polgar, E., Gangadharan Vijayan, Andrew J Todd, Kurejova, Martina, Feil, Susanne, Ceng Luo, Hu, S., Susanne Feil (179376), Andrew J. Todd (179384), Feil, R., Rohini Kuner (179428), Erika Polgar (5649442), Rohini Kuner, Hu, San-Jue, Liu Da-Lu, Liu, D., Kuner, Thomas, San-Jue Hu (179417), Feil, S., Tegeder, Irmgard, Tappe-Theodor Anke, Kuner, R., Nitin Agarwal (179363), Robert Feil (28669), Agarwal, N., Agarwal Nitin, Xie, R.G., Robert Feil, Kiran Kumar Bali (179358), Da-Lu Liu (179408), Erika Polgar, Kuner, T., Tappe, Anke, Gary Lewin (179380), Liu, Da-Lu, Xie, R. G., Jens Schlossmann (179389), Nitin Agarwal, Luo, Ceng, Luo, C., Vijayan Gangadharan, Hu, S. J., Xie, Rou-Gang, Hofmann Franz, Da-Lu Liu, Rou-Gang Xie (179362), Bali Kiran Kumar, Tappe-Theodor, A., Kuner, Rohini, Lewin Gary, Liu, D. L., Kiran Kumar Bali, Irmgard Tegeder, Polgár, Erika, Hofmann, Franz, Tegeder Irmgard, Vijayan Gangadharan (179356), Rou-Gang Xie, Schlossmann Jens, Franz Hofmann, Feil Susanne, Hu San-Jue, San-Jue Hu, Xie Rou-Gang, Gangadharan, Vijayan, Todd Andrew J., Feil Robert, Martina Kurejova (179365), Bali, K. K., Gary Lewin, Susanne Feil, Anke Tappe-Theodor (179367), Lewin, Gary R., Schlossmann, Jens, Liu, D.L., Thomas Kuner (162293), Schlossmann, J., Luo Ceng, Gangadharan, V., Hofmann, F., Kuner Rohini, Todd, Andrew J., Xie, R., Tegeder, I., Kurejova, M.   +102 more
core   +1 more source

Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation [PDF]

Biochemical Journal, 1998
cGMP-binding phosphodiesterases contain two homologous allosteric cGMP-binding sites (sites and ) that are arranged in tandem; they constitute a superfamily of mammalian cyclic nucleotide receptors distinct from the cyclic nucleotide-dependent protein kinases/cation channels family.
I V, Turko, S H, Francis, J D, Corbin
openaire   +5 more sources

cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction

Respiratory Research, 2018
Background The nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact molecular mechanism remains ...
Lihui Zou, Junhua Zhang, Jingli Han, Wenqing Li, Fei Su, Xiaomao Xu, Zhenguo Zhai, Fei Xiao   +7 more
doaj   +1 more source

Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery

Nitric Oxide, 2019
The development of small molecule modulators of NO/cGMP signaling for use in the CNS has lagged far behind the use of such clinical agents in the periphery, despite the central role played by NO/cGMP in learning and memory, and the substantial evidence that this signaling pathway is perturbed in neurodegenerative disorders, including Alzheimer's ...
Michael A. Hollas, Manel Ben Aissa, Sue H. Lee, Jesse M. Gordon-Blake, Gregory R.J. Thatcher   +4 more
openaire   +3 more sources

The role of cGMP and PKG-I in spinal nociceptive processing

, 2005
First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia.
Geisslinger, Gerd, Schmidtko, Achim, Gerd Geisslinger, Ruth, Peter, Niederberger, Ellen, Achim Schmidtko, Irmgard Tegeder, Franz Hofmann, Hofmann, Franz, Peter Ruth, Ellen Niederberger, Tegeder, Irmgard   +11 more
core   +1 more source

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites [PDF]

, 2014
This work was funded by grants from the Wellcome Trust (WT098051 and 079643/Z/06/Z) and the Medical Research Council (G0501670) to OB, a Wellcome Trust project grant to DB (WT094752), a Wellcome Trust Grant (WT093228) to TKS, a Marie Curie Fellowship ...
Katrin Volkmann, Chappell, Lia, Brochet, M., Oliver Billker, Eloise Thompson, Billker, Oliver,, Mathieu Brochet, Berriman, Matthew, Jyoti Choudhary (261900), Frank Schwach, Rayner, Julian C., Rayner, Julian C, Jyoti Choudhary, Lia Chappell (530631), Sebastian, Sarah, Lia Chappell, Chappell, L., Terry K. Smith (112550), Gomes, Ana Rita, Frank Schwach (530630), Ana Rita Gomes, Oliver Billker (92636), Smith, T.K., Thompson, E., Schwach, F., Sebastian, S., Baker, David A, Volkmann, K., Sarah Sebastian (530629), Volkmann, Katrin, David A Baker, Terry K Smith, Ana Rita Gomes (220735), Collins, Mark O., Smith, Terry K., Mark O Collins, Gomes, A.R., Collins, M.O., David A. Baker (122252), Choudhary, J., Julian C Rayner, Brochet, Mathieu, Mathieu Brochet (149272), Billker, Oliver, Collins, Mark O, Mark O. Collins (131229), Billker, O., Schwach, Frank, Berriman, M., Sarah Sebastian, Rayner, J.C., Matthew Berriman (5353), Baker, David A., Thompson, Eloise, Smith, Terry K, Matthew Berriman, Choudhary, Jyoti, Eloise Thompson (376344), Baker, D.A., Julian C. Rayner (121198), Katrin Volkmann (149256)   +60 more
core   +1 more source