A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. [PDF]
PLoS Pathogens, 2009 The ookinete is a motile stage in the malaria life cycle which forms in the mosquito blood meal from the zygote. Ookinetes use an acto-myosin motor to glide towards and penetrate the midgut wall to establish infection in the vector.
Robert W Moon +8 more
doaj +2 more sources
Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth [PDF]
Cell Reports, 2016 Sildenafil, an inhibitor of the cGMP-degrading phosphodiesterase 5 that is used to treat erectile dysfunction, has been linked to an increased risk of melanoma. Here, we have examined the potential connection between cGMP-dependent signaling cascades and
Sandeep Dhayade +13 more
doaj +3 more sources
The role of cGMP and PKG-I in spinal nociceptive processing [PDF]
, 2005 First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia.
Geisslinger, Gerd +11 more
core +1 more source
Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo [PDF]
, 2014 Nitric oxide (NO) is a critical negative regulator of platelets that is implicated in the pathology of thrombotic diseases. Platelets generate NO, but the presence and functional significance of NO synthase (NOS) in platelets is unclear.
GL Apostoli (21829550) +4 more
core +6 more sources
cGMP becomes a drug target [PDF]
, 2012 Cyclic guanosine 3',5'-monophosphate (cGMP) serves as a second messenger molecule, which regulates pleiotropic cellular functions in health and disease.
Schlossmann, Jens +3 more
core +2 more sources
The role of cGMP signalling in regulating life cycle progression of Plasmodium. [PDF]
, 2012 The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont ...
Baker, David A +2 more
core +1 more source
The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel [PDF]
, 2011 Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. Here, we show for the first time that in the HCN2 channel
Biel Martin +15 more
core +2 more sources
cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis [PDF]
, 2009 Background Endothelium-derived nitric oxide plays an important role for the bone marrow microenvironment. Since several important effects of nitric oxide are mediated by cGMP-dependent pathways, we investigated the role of the cGMP downstream effector ...
Feil, Robert +15 more
core +2 more sources
CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]
, 2012 The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick +23 more
core +1 more source
, 2022 P-values for comparison of the different groups G1-G5, representing G1(N-CGMP), G2 (N-CGMP-LNAA), G3 (N), G4 (CGMP-EAA-LP) and G5 (FSAA-LP).
Karen S. Johansen (11933727) +14 more
core +1 more source