Results 11 to 20 of about 70,973 (282)
A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. [PDF]
PLoS Pathogens, 2009 The ookinete is a motile stage in the malaria life cycle which forms in the mosquito blood meal from the zygote. Ookinetes use an acto-myosin motor to glide towards and penetrate the midgut wall to establish infection in the vector.
Robert W Moon +8 more
doaj +2 more sources
Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth [PDF]
Cell Reports, 2016 Sildenafil, an inhibitor of the cGMP-degrading phosphodiesterase 5 that is used to treat erectile dysfunction, has been linked to an increased risk of melanoma. Here, we have examined the potential connection between cGMP-dependent signaling cascades and
Sandeep Dhayade +13 more
doaj +2 more sources
Biochemistry, 2008 We describe here a novel sensor for cGMP based on the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase 5 (PDE5) using bioluminescence resonance energy transfer (BRET). The wild type GAFa domain, capable of binding cGMP with high affinity, and a mutant (GAFa F163A) unable to bind cGMP were cloned as fusions between GFP and Rluc for BRET ...
Biswas, Kabir Hassan +2 more
openaire +3 more sources
Insights into cGMP signalling derived from cGMP kinase knockout mice
Frontiers in Bioscience, 2005 cGMP signalling plays an important physiological role in diverse organs including the vasculature, the GI-tract and the nervous system. Furthermore, cGMP-elevating substances such as glyceryl trinitrate are important drugs used in cardiovascular diseases.
Jens, Schlossmann +2 more
openaire +3 more sources
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action [PDF]
Pharmacological Reviews, 2010 To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs). Effects of cGMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation ...
Sharron H, Francis +3 more
openaire +2 more sources
Deciphering cGMP signatures and cGMP-dependent pathways in plant defence [PDF]
Plant Signaling & Behavior, 2009 The second messenger, 3′,5′-cyclic monophosphate (cGMP), is a critical component of many different processes in plants while guanylyl cyclases that catalyse the formation of cGMP from GTP have remained somewhat elusive in higher plants. Consequently, two major aims are the discovery of novel GCs and the identification of cGMP mediated processes ...
Meier S. +5 more
openaire +3 more sources
cGMP becomes a drug target [PDF]
, 2012 Cyclic guanosine 3',5'-monophosphate (cGMP) serves as a second messenger molecule, which regulates pleiotropic cellular functions in health and disease.
Schlossmann, Jens +3 more
core +1 more source
The role of cGMP signalling in regulating life cycle progression of Plasmodium. [PDF]
, 2012 The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont ...
Baker, David A +2 more
core +1 more source
The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel [PDF]
, 2011 Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. Here, we show for the first time that in the HCN2 channel
Biel Martin +14 more
core +1 more source
, 2022 P-values for comparison of the different groups G1-G5, representing G1(N-CGMP), G2 (N-CGMP-LNAA), G3 (N), G4 (CGMP-EAA-LP) and G5 (FSAA-LP).
Karen S. Johansen (11933727) +14 more
core +1 more source