Results 11 to 20 of about 56,515 (255)

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action [PDF]

Pharmacological Reviews, 2010
To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs). Effects of cGMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation ...
Sharron H, Francis, Jennifer L, Busch, Jackie D, Corbin, David, Sibley   +3 more
openaire   +2 more sources

Deciphering cGMP signatures and cGMP-dependent pathways in plant defence [PDF]

Plant Signaling & Behavior, 2009
The second messenger, 3′,5′-cyclic monophosphate (cGMP), is a critical component of many different processes in plants while guanylyl cyclases that catalyse the formation of cGMP from GTP have remained somewhat elusive in higher plants. Consequently, two major aims are the discovery of novel GCs and the identification of cGMP mediated processes ...
Meier S., MADEO, LAURA, EDERLI, Luisa, Donaldson L., PASQUALINI, Stefania, Gehring C.   +5 more
openaire   +3 more sources

Expanding Therapeutic Horizons: A Review of Tadalafil’s Off-Label Applications and Pharmacological Profile [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Phosphodiesterase type 5 inhibitors (PDE5-Is), have initially revolutionized the treatment of erectile dysfunction (ED). Among these, Tadalafil (TDL) stands out due to its unique pharmacokinetic properties and extended half-life. This review explores the
Yara Abdelhady, Mina Y. George, Eman M. Mantawy   +2 more
doaj   +1 more source

It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3

Communications Biology, 2023
The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac cells revealed NO-induced cGMP signals in cardiac fibroblasts while cardiomyocytes were devoid of these ...
Lukas Menges, Jan Giesen, Kerem Yilmaz, Evanthia Mergia, Annette Füchtbauer, Ernst-Martin Füchtbauer, Doris Koesling, Michael Russwurm   +7 more
doaj   +1 more source

The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to γ Subunit of the Photoreceptor cGMP Phosphodiesterase [PDF]

Journal of Biological Chemistry, 1997
The cGMP phosphodiesterase from retinal rods (PDE-6) is an alphabetagamma2 heterotetramer. The alpha and beta subunits contain catalytic sites for cGMP hydrolysis, whereas the gamma subunits serve as a protein inhibitor of the enzyme. Visual excitation of photoreceptors enables the activated GTP-bound form of the G-protein transducin to remove the ...
Lochhead, A, Nekrasova, E, Arshavsky, V Y, Pyne, N J   +3 more
openaire   +4 more sources

Removal of cumulus cells around 20 h after the start of in vitro maturation improves the meiotic competence of porcine oocytes via reduction in cAMP and cGMP levels

The Journal of Reproduction and Development, 2019
We examined the effect of the timing of removing cumulus cells surrounding porcine oocytes from small follicles (SFs, < 3 mm in diameter) and medium follicles (MFs; 3–6 mm in diameter) on the meiotic and developmental competence of the oocytes ...
Pilar FERRÉ-PUJOL, Xuan Khanh NGUYEN, Tomoki NAGAHARA, Thi Tra Mi BUI, Takuya WAKAI, Hiroaki FUNAHASHI   +5 more
doaj   +1 more source

Plasma Cyclic Guanosine Monophosphate Is a Promising Biomarker of Clinically Significant Portal Hypertension in Patients With Liver Cirrhosis

Frontiers in Medicine, 2022
Introduction: Despite intensive research, reliable blood-derived parameters to detect clinically significant portal hypertension (CSPH) in patients with cirrhosis are lacking.
Lukas Sturm, Lukas Sturm, Dominik Bettinger, Lisa Roth, Katharina Zoldan, Laura Stolz, Chiara Gahm, Jan Patrick Huber, Marlene Reincke, Rafael Kaeser, Rafael Kaeser, Tobias Boettler, Wolfgang Kreisel, Robert Thimme, Michael Schultheiss   +14 more
doaj   +1 more source

Therapeutic benefits of Phosphodiesterase type 5 inhibitors: A comprehensive review [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Phosphodiesterase type 5 (PDE5) inhibitors have been widely used to treat erectile dysfunction. This review aims to explore the favorable effects of PDE5 inhibitors in clinical applications beyond their conventional use.
Yasmin Nabil, Yara M. Aboelmagd, Christine Nathan Habib, ٍamar S. Azab   +3 more
doaj   +1 more source

The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model.

PLoS ONE, 2022
IntroductionManagement of phenylketonuria (PKU) is mainly achieved through dietary control with limited intake of phenylalanine (Phe) from food, supplemented with low protein (LP) food and a mixture of free synthetic (FS) amino acids (AA) (FSAA).
Kirsten K Ahring, Frederik Dagnæs-Hansen, Annemarie Brüel, Mette Christensen, Erik Jensen, Thomas G Jensen, Mogens Johannsen, Karen S Johansen, Allan M Lund, Jesper G Madsen, Karen Brøndum-Nielsen, Michael Pedersen, Lambert K Sørensen, Mads Kjolby, Lisbeth B Møller   +14 more
doaj   +1 more source

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation.
Wendy Ying, Di Zhao, Pamela Ouyang, Vinita Subramanya, Dhananjay Vaidya, Chiadi E. Ndumele, Eliseo Guallar, Kavita Sharma, Sanjiv J. Shah, David A. Kass, Ron C. Hoogeveen, Joao A. Lima, Susan R. Heckbert, Christopher R. deFilippi, Wendy S. Post, Erin D. Michos   +15 more
doaj   +1 more source