Results 21 to 30 of about 70,973 (282)

The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to γ Subunit of the Photoreceptor cGMP Phosphodiesterase [PDF]

Journal of Biological Chemistry, 1997
The cGMP phosphodiesterase from retinal rods (PDE-6) is an alphabetagamma2 heterotetramer. The alpha and beta subunits contain catalytic sites for cGMP hydrolysis, whereas the gamma subunits serve as a protein inhibitor of the enzyme. Visual excitation of photoreceptors enables the activated GTP-bound form of the G-protein transducin to remove the ...
Lochhead, A, Nekrasova, E, Arshavsky, V Y, Pyne, N J   +3 more
openaire   +4 more sources

CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]

, 2012
The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick, Albert C Ludolph, Hans A Kretzschmar, Ludolph, Albert C., Markus Otto, Kretzschmar, Hans A., Petra Steinacker, Stefan Lehnert, Ferger Boris, Patrick Oeckl, Otto, Markus, Ferger, Boris, Oeckl Patrick, Ludolph Albert C., Boris Ferger, Steinacker, Petra, Otto Markus, Lehnert Stefan, Steinacker Petra, Kretzschmar Hans A., Jesse, Sarah, Lehnert, Stefan, Sarah Jesse, Jesse Sarah   +23 more
core   +1 more source

Therapeutic benefits of Phosphodiesterase type 5 inhibitors: A comprehensive review [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Phosphodiesterase type 5 (PDE5) inhibitors have been widely used to treat erectile dysfunction. This review aims to explore the favorable effects of PDE5 inhibitors in clinical applications beyond their conventional use.
Yasmin Nabil, Yara M. Aboelmagd, Christine Nathan Habib, ٍamar S. Azab   +3 more
doaj   +1 more source

NO-cGMP-K channel-dependent anti-nociceptive activities of methanol stem bark extract of Piptadeniastrum africanum (Mimosaceae) on rats

Asian Pacific Journal of Tropical Biomedicine, 2018
Objective: To explore anti-hyperalgesic properties of methanol extract of Piptadeniastrum africanum stem bark (PAME) and it possible action mechanism.
Mbiantcha Marius, Almas Jabeen, Ateufack Gilbert, Shabana U Simjee, Bomba Tatsinkou Francis Desire, Nida Dastagir   +5 more
doaj   +1 more source

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase. [PDF]

, 2012
Signalling by 3'-5'-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes. In the apicomplexan parasite Plasmodium, the cGMP-dependent protein kinase (PKG) has previously been reported to play a critical role in four key stages of the ...
Baker, David A, Lev Solyakov (122244), Solyakov, Lev, David A Baker, Flueck, Christian, Lev Solyakov, L. Solyakov (7638338), Hopp Christine S., Flueck Christian, Andrew Tobin (122248), David A. Baker (122252), Christine S Hopp, David A. Baker, D. A. Baker (7638335), A. B. Tobin (7638326), Solyakov Lev, C. Flueck (7638332), Andrew Tobin, Christine S. Hopp (122239), Baker David A., Tobin Andrew, Christian Flueck, C. S. Hopp (7638329), Tobin, Andrew, Christian Flueck (122240), Hopp, Christine S   +25 more
core   +1 more source

In Silico Mapping of Essential Residues in the Catalytic Domain of PDE5 Responsible for Stabilization of Its Commercial Inhibitors

Scientia Pharmaceutica, 2019
Phosphodiesterase type 5 (PDE5) is an important enzyme associated with the hydrolysis of cyclic guanosine monophosphate (cGMP) to guanosine monophosphate (GMP).
Ivan Pires de Oliveira, Caroline Honaiser Lescano, Gilberto De Nucci   +2 more
doaj   +1 more source

Plasma Cyclic Guanosine Monophosphate Is a Promising Biomarker of Clinically Significant Portal Hypertension in Patients With Liver Cirrhosis

Frontiers in Medicine, 2022
Introduction: Despite intensive research, reliable blood-derived parameters to detect clinically significant portal hypertension (CSPH) in patients with cirrhosis are lacking.
Lukas Sturm, Lukas Sturm, Dominik Bettinger, Lisa Roth, Katharina Zoldan, Laura Stolz, Chiara Gahm, Jan Patrick Huber, Marlene Reincke, Rafael Kaeser, Rafael Kaeser, Tobias Boettler, Wolfgang Kreisel, Robert Thimme, Michael Schultheiss   +14 more
doaj   +1 more source

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. [PDF]

, 2013
The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoite surface are modified by an essential parasite serine ...
Baker, David A, Strath Malcolm, Maria Penzo, David A Baker, Hackett Fiona, Penzo, Maria, Blackman, Michael J, Michael J Blackman, David A. Baker (122252), Christine R Collins, Fiona Hackett (27620), Christine R. Collins, Strath, Malcolm, Withers-Martinez, Chrislaine, David A. Baker, Michael J. Blackman, Malcolm Strath (411645), Withers-Martinez Chrislaine, Penzo Maria, Chrislaine Withers-Martinez, Malcolm Strath, Collins Christine R., Hackett, Fiona, Fiona Hackett, Chrislaine Withers-Martinez (27619), Baker David A., Collins, Christine R, Christine R. Collins (191982), Michael J. Blackman (192013), Blackman Michael J., Maria Penzo (411646)   +30 more
core   +1 more source

Expanding Therapeutic Horizons: A Review of Tadalafil’s Off-Label Applications and Pharmacological Profile [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Phosphodiesterase type 5 inhibitors (PDE5-Is), have initially revolutionized the treatment of erectile dysfunction (ED). Among these, Tadalafil (TDL) stands out due to its unique pharmacokinetic properties and extended half-life. This review explores the
Yara Abdelhady, Mina Y. George, Eman M. Mantawy   +2 more
doaj   +1 more source

Thrombin has biphasic effects on the nitric oxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension. [PDF]

PLoS ONE, 2013
BACKGROUND: A potential role for coagulation factors in pulmonary arterial hypertension has been recently described, but the mechanism of action is currently not known.
Katrin F Nickel, Volker Laux, Rolf Heumann, Georges von Degenfeld   +3 more
doaj   +1 more source