Results 61 to 70 of about 77,168 (243)

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

In vitro expression of cyclic guanosine monophosphate (cGMP) in the outer plexiform layer of a detached retina

, 2011
Copyright information:Taken from "Cyclic GMP in the pig vitreous and retina after experimental retinal detachment"Molecular Vision 2008;14():255-261.Published online 04 Feb 2008PMCID:PMC2254957.
Marijke A.M. Lemmens (87953), Aize Kijlstra (52532), Ellen C. La Heij (87952), Roselie M.H. Diederen (87951), Fred Hendrikse (87955), Jan de Vente (87954)   +5 more
core   +1 more source

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

cGMP Signaling and Vascular Smooth Muscle Cell Plasticity

Journal of Cardiovascular Development and Disease, 2018
Cyclic GMP regulates multiple cell types and functions of the cardiovascular system. This review summarizes the effects of cGMP on the growth and survival of vascular smooth muscle cells (VSMCs), which display remarkable phenotypic plasticity during the ...
Moritz Lehners, Hyazinth Dobrowinski, Susanne Feil, Robert Feil   +3 more
doaj   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Association of elevated cyclic GMP levels with hemodynamic changes in HFrEF patients treated with sacubitril/valsartan and vericiguat: a pilot study

International Journal of Cardiology: Heart & Vasculature
Background: Patients with heart failure (HF) often present with a relative deficiency of cyclic guanosine monophosphate (cGMP) despite elevated B-type natriuretic peptide (BNP) levels.
Takumi Inoue, Hiroyuki Takahama, Hideaki Suzuki, Marina Arai, Nobuhiro Kikuchi, Taijyu Satoh, Nobuhiro Yaoita, Saori Yamamoto, Kotaro Nochioka, Makoto Nakano, Shunsuke Tatebe, Jun Takahashi, Naoto Minamino, Satoshi Yasuda   +13 more
doaj   +1 more source

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide

Frontiers in Neuroscience, 2019
PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders.
John F. Harms, Frank S. Menniti, Christopher J. Schmidt   +2 more
doaj   +1 more source

Cyclic GMP in the pig vitreous and retina after experimental retinal detachment [PDF]

, 2008
Purpose: Earlier studies have revealed a decreased level of cGMP in vitreous fluid obtained from patients with a retinal detachment. To further investigate this phenomenon, we developed an experimental retinal detachment model in pigs.
Heij, E.C., La, La Heij, Ellen C, Diederen, R., Diederen, Roselie M H, Lemmens, Marijke A M, de Vente, Jan, De Vente, J., La Heij, E.C., Lemmens, M.A.M., Kijlstra, Aize, Vente, J., De, Hendrikse, F., Hendrikse, Fred, Kijlstra, A.   +13 more
core  

Reduction Process of Pt(IV) Complexes With Axial Acetato Ligands by Ascorbic Acid; Comparison of Experimental and Computational Tools

Chemistry – A European Journal, EarlyView.
Comparison of experimental and calculated rate constants for reduction of selected Pt(IV) complexes by ascorbic acid (AA) in water solution at pH = 7. ABSTRACT In the present work, the reduction mechanism of several Pt(IV) complexes bearing two axial acetato ligands by ascorbic acid (AA) was investigated.
Ondřej Tichý, Patrick A. Yassemipour, Christian R. Kowol, Jaroslav V. Burda   +3 more
wiley   +1 more source

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Frontiers in Molecular Neuroscience, 2014
Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation and release of cyclic guanosine-3’,5’-monophosphate (
Gerhard eHannig, Boris eTchernychev, Caroline B Kurtz, Alexander P Bryant, Mark G Currie, Inmaculada eSilos-Santiago   +5 more
doaj   +1 more source