Acta Physiologica, Volume 242, Issue 2, February 2026.ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
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Molecular mechanisms of plant NLR activation and signalling
The Plant Journal, Volume 125, Issue 3, February 2026.SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta +3 more
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NO-cGMP pathway increases the hyperpolarisation-activated current, If, and heart rate during adrenergic stimulation [PDF]
, 2001 Neil Herring
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Experimental Physiology, Volume 111, Issue 2, Page 474-488, 1 February 2026.Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber +10 more
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The cGMP System in Irradiated Animals Changes in cGMP Content and Activities of Guanylate Cyclase and Cyclic Nucleotide Phosphodiesterase [PDF]
, 1984 Alexander S. Sobolev +2 more
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hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li +8 more
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Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa +5 more
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Pharmacologically increasing cGMP improves proteostasis and reduces neuropathy in mouse models of CMT1 [PDF]
Seth M. Moore +7 more
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The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to γ Subunit of the Photoreceptor cGMP Phosphodiesterase [PDF]
, 1997 Amanda Lochhead +3 more
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