Results 121 to 130 of about 55,160 (145)

(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor

European Journal of Pharmacology: Molecular Pharmacology, 1994
In the present study, the inhibitory effect of the cGMP analog (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate ((Rp)-8-pCPT-cGMPS) on the cGMP-dependent protein kinase-mediated protein phosphorylation in intact human platelets was investigated.
E, Butt, M, Eigenthaler, H G, Genieser
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cGMP Pump

Science Signaling, 2000
Cyclic nucleotides are important second messengers. Jedlitschky et al . expressed the human multidrug resistance protein 5 (MDR5) in hamster fibroblasts and showed that these cells exhibit an enhanced high-affinity ATP-dependent transport of cyclic nucleotides into inside-out membrane vesicles.
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Modulation of synaptic function by cGMP and cGMP-gated cation channels

Neurochemistry International, 2004
Cyclic nucleotide-gated cation channels have been studied intensively in the primary sensory neurons of the visual and olfactory systems. Using both anatomical and physiological methods we have shown that they have a much more widespread distribution in the nervous system.
Colin J, Barnstable, Ji-Ye, Wei, Ming-Hu, Han   +2 more
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cGMP in the Vasculature

2009
Cyclic guanosine 3', 5'-monophosphate (cGMP) plays an integral role in the control of vascular function. Generated from guanylate cyclases in response to the endogenous ligands, nitric oxide (NO) and natriuretic peptides (NPs), cGMP influences a number of vascular cell types and regulates vasomotor tone, endothelial permeability, cell growth and ...
Barbara, Kemp-Harper, Harald H H W, Schmidt   +1 more
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cGMP and cell processing

Cytotherapy, 1999
Over the past 20 years cell processing has changed. What an under statement! The types of cells processed, the complexity of the procedures, the addition of gene therapy and ex vivo cell expansion protocols together challenge the laboratory scientist.
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cGMP production in bacteria

Molecular and Cellular Biochemistry, 2009
Production of cGMP in bacteria has been studied since the early 1970s. From the beginning on it proved to be a challenging topic. In Escherichia coli the cGMP levels were two orders of magnitude lower than the corresponding cAMP levels. Furthermore, no specific cGMP receptor protein was identified in the bacterium and a physiological role of cGMP in ...
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NO-cGMP-System

2018
NO wird in Endothelzellen synthetisiert und aktiviert in glatten Muskelzellen die sGC, die den second messenger cGMP produziert. Die wichtigste Funktion von cGMP ist die Relaxation glatter Muskelzellen. cGMP wird uber die PDE5 abgebaut. Der NO-Donator GTN aktiviert die sGC und relaxiert Muskelzellen.
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cGMP and cGMP-Dependent Protein Kinase in Platelets and Blood Cells

2009
Platelets are specialized adhesive cells that play a key role in normal and pathological hemostasis through their ability to rapidly adhere to subendothelial matrix proteins (platelet adhesion) and to other activated platelets (platelet aggregation). NO plays a crucial role in preventing platelet adhesion and aggregation.
Ulrich, Walter, Stepan, Gambaryan
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cGMP signal termination

Biochemical Society Transactions, 1996
N J, Pyne, V, Arshavsky, A, Lochhead
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cGMP-lmmunocytochemistry

2003
J, de Vente, H W, Steinbusch
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