Results 121 to 130 of about 148,798 (282)

Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice [PDF]

open access: yes, 2017
Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity ...
Allen, Kaitlin   +15 more
core   +1 more source

Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration

open access: yesNeurobiology of Disease, 2019
The nitric oxide – guanylyl cyclase-1 – cyclic guanylate monophosphate (NO-GC-1–cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degeneration of ...
Lauren K. Wareham   +10 more
doaj  

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia

open access: yesRedox Biology, 2021
3′,5′-cyclic guanosine monophosphate (cGMP) is a druggable second messenger regulating cell growth and survival in a plethora of cells and disease states, many of which are associated with hypoxia. For example, in myocardial infarction and heart failure (
Nadja I. Bork   +11 more
doaj  

NO/cGMP signalling [PDF]

open access: yesBMC Pharmacology, 2005
Michael Russwurm   +6 more
openaire   +2 more sources

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