Results 191 to 200 of about 43,468 (306)

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings   +6 more
wiley   +1 more source

Persistence, switching, and healthcare use after initiating calcitonin gene-related peptide inhibitors: a real-world assessment. [PDF]

open access: yesJ Headache Pain
Moura CS   +7 more
europepmc   +1 more source

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez   +11 more
wiley   +1 more source

Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models

open access: gold
Nathan Nelson-Maney   +8 more
openalex   +1 more source

Endothelin-converting-enzyme 1 inhibition and CGRP receptor recycling in human coronary and middle meningeal arteries

open access: gold, 2013
Sieneke Labruijere   +4 more
openalex   +1 more source

Systemic Arterial Stiffness in Reversible Cerebral Vasoconstriction Syndrome: A Prospective Case–Control Study

open access: yesEuropean Journal of Neurology, Volume 33, Issue 2, February 2026.
No significant differences were observed at any stage of the RCVS course between patients and controls. Systemic arterial stiffness, as assessed by PWV, remained normal and stable throughout the course of RCVS. No systemic complication has been detected during the RCVS course.
Pacôme Constant dit Beaufils   +7 more
wiley   +1 more source

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