Results 221 to 230 of about 50,213 (312)

The exposomal imprint on rosacea: More than skin deep

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 387-403, March 2026.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki, Daniella Bakoli Sgourou, Alexandros Maniatis, Efstathia Pasmatzi   +3 more
wiley   +1 more source

Could galcanezumab modulate inflammatory cytokines? A single-centre exploratory study. [PDF]

J Neurol
Ceccardi G, Rao R, Schiano di Cola F, Fiducia B, Tolassi C, Quaresima V, Mattioli I, Eshja K, Cresta E, Gipponi S, Pilotto A, Padovani A.   +11 more
europepmc   +1 more source

Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models

Nathan Nelson-Maney, László Bálint, Anna L. S. Beeson, Donald Serafín, Bryan M. Kistner, Elizabeth S Douglas, A Siddiqui, Alyssa M Tauro, Kathleen M. Caron   +8 more
openalex   +1 more source

Therapeutic advances in pruritus as a model of personalized medicine

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 415-422, March 2026.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung, Ramsey Kubofcik, Brian S. Kim   +2 more
wiley   +1 more source

Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 423-430, March 2026.
This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang, Zhiqin Fang, Lam C. Tsoi, Johann E. Gudjonsson   +3 more
wiley   +1 more source

Trigeminal nerve root compression induced neuroinflammatory response promotes mechanical allodynia through the CGRP/SP-Piezo2 axis via Ca2+ signaling

Xinyue Liao, Zhaoke Luo, Feng Huang, Yiqian Wang, Zheng Zeng, Wenting Liao, Yushan Ou, Xuemei Wu, Feng Wang, Daoshu Luo   +9 more
openalex   +1 more source

Exploring the Bidirectional Association Between Migraine and Temporomandibular Disorders: A Systematic Review and Meta‐Analysis

Journal of Oral Rehabilitation, Volume 53, Issue 3, Page 794-806, March 2026.
DC/TMD: Diagnostic Criteria for Temporomandibular Disorders; RDC/TMD: Research Diagnostic Criteria for Temporomandibular Disorders; ICHD: International Classification of Headache Disorders. OR: Odds Ratio. ABSTRACT Background Migraine and temporomandibular disorders (TMD) are comorbid conditions that are highly frequent among patients.
Marlon Ferreira Dias, Amanda Costa Ferro, Juliana Homem Padilha Spavieri, Túlio Morandin Ferrisse, Daniela Aparecida de Godoi Gonçalves   +4 more
wiley   +1 more source

Calcitonin Gene-Related Peptide Inhibitors and Cardiovascular Events in Patients With Migraine: A Retrospective, Observational Cohort Study. [PDF]

Neurology
Lusk JB, Wilson LE, Moore C, Yarnell S, Kalapura C, Choudhury A, Schrag M, Poli S, Li F, Mac Grory B.   +9 more
europepmc   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, Volume 111, Issue 3, Page 653-673, 1 March 2026.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Changes in interictal cerebral blood flow observed in migraine patients who respond to anti-calcitonin gene-related peptide therapy. [PDF]

Sci Rep
Shimoda M, Hoshikawa K, Oda S, Imai M, Aoki R, Shinohara C.   +5 more
europepmc   +1 more source