Results 231 to 240 of about 33,931 (282)
Some of the next articles are maybe not open access.
CGRP receptors: beyond the CGRP1–CGRP2 subdivision?
Trends in Pharmacological Sciences, 2001In a recent TiPS article 1xThe molecular pharmacology of CGRP and related peptide receptor subtypes. Juaneda, C. et al. Trends Pharmacol. Sci. 2000; 21: 432–438Abstract | Full Text | Full Text PDF | PubMed | Scopus (131)See all References1, Juaneda and colleagues reviewed the molecular pharmacology of calcitonin gene-related peptide (CGRP) and related ...
D, Poyner, I, Marshall
openaire +2 more sources
The activation of the CGRP receptor
Biochemical Society Transactions, 2013The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR.
Barwell, James +6 more
openaire +3 more sources
2012
Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor.
James, Barwell +4 more
openaire +2 more sources
Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor.
James, Barwell +4 more
openaire +2 more sources
Headache: The Journal of Head and Face Pain, 2017
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still evolving target for migraine. A fundamental consideration for all of the current drugs in clinical trials and for ongoing development in this area is the identity, expression pattern, and function of CGRP receptors because this knowledge ...
Debbie L. Hay, Christopher S. Walker
openaire +2 more sources
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still evolving target for migraine. A fundamental consideration for all of the current drugs in clinical trials and for ongoing development in this area is the identity, expression pattern, and function of CGRP receptors because this knowledge ...
Debbie L. Hay, Christopher S. Walker
openaire +2 more sources
Recognizing the role of CGRP and CGRP receptors in migraine and its treatment
Cephalalgia, 2017Premise The brain and the sensory nervous system contain a rich supply of calcitonin gene-related peptide (CGRP) and CGRP receptor components. Clinical studies have demonstrated a correlation between CGRP release and acute migraine headache that led to the development of CGRP-specific drugs that either abort ...
Edvinsson, Lars, Warfvinge, Karin
openaire +3 more sources
2018
Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we are in the interesting situation of having the approval for the clinical use of antagonists and antibodies ...
Arkless, Kate +2 more
openaire +3 more sources
Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we are in the interesting situation of having the approval for the clinical use of antagonists and antibodies ...
Arkless, Kate +2 more
openaire +3 more sources
CGRP Immunoreactivity in the Mammalian Pancreasa
Annals of the New York Academy of Sciences, 1992not ...
Sternini C +5 more
openaire +3 more sources
Headache Currents, 2004
Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons We examined the regulation of calcitonin gene‐related peptide (CGRP) promoter activity in primary cultures of rat trigeminal ganglia neurons.
openaire +1 more source
Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons We examined the regulation of calcitonin gene‐related peptide (CGRP) promoter activity in primary cultures of rat trigeminal ganglia neurons.
openaire +1 more source