Results 221 to 230 of about 33,931 (282)

Exosomes from mesenchymal stem/stromal cells and their therapeutic role in osteoarthritic pain. [PDF]

J Exp Orthop
Kouroupis D, Jergova S, Sagen J, Best TM.   +3 more
europepmc   +1 more source

Beyond AQP-4: convergent glymphatic-meningeal lymphatic dysfunction underlying multifactorial migraine pathogenesis. [PDF]

Front Immunol
Yang MF, Song MM, Gao YJ, Chen TY, Xu SY.   +4 more
europepmc   +1 more source

Plasma CGRP Levels in Migraine: A Registry for Migraine Study. [PDF]

Neurology
Karlsson WK, Christensen RH, Al-Khazali HM, Haanes KA, Jørgensen NR, Ashina M, Ashina H.   +6 more
europepmc   +1 more source

Role of CGRP in Migraine

, 2019
Migraine is a common neurological disorder that afflicts up to 15% of the adult population in most countries, with predominance in females. It is characterized by episodic, often disabling headache, photophobia and phonophobia, autonomic symptoms (nausea and vomiting), and in a subgroup an aura in the beginning of the attack.
Edvinsson, Lars, Lars Edvinsson
core   +5 more sources

T he T rigeminovascular P athway: R ole of CGRP and CGRP R eceptors in M igraine

Headache, 2017
The trigeminal ganglion plays a key role in primary headache pathophysiology. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in trigeminal neurons that form C-fibers and A-fibers, respectively.
Lars Edvinsson
exaly   +2 more sources

Inhibitory effect of BIBN4096BS, CGRP8-37 , a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery

British Journal of Pharmacology, 2007
Background and purpose: A new concept for the inhibition of CGRP signalling has been developed by interaction with the CGRP molecule per se by using a CGRP antibody or a CGRP binding RNA-Spiegelmer (NOX-C89).
Lars Edvinsson
exaly   +3 more sources

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CGRP antagonists: unravelling the role of CGRP in migraine

Trends in Pharmacological Sciences, 2007
Migraine is a complex, debilitating neurovascular disorder. Although knowledge on the main molecular players is still incomplete, recent preclinical and clinical findings indicate that there is a clear correlation between migraine-associated headache and the release of the neuropeptide calcitonin gene-related peptide (CGRP). BIBN4096 was the first CGRP
Henri, Doods, Kirsten, Arndt, Klaus, Rudolf, Stefan, Just   +3 more
openaire   +2 more sources

Distribution of CGRP and CGRP receptor components in the rat brain

Cephalalgia, 2017
Background Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies.
Warfvinge, Karin, Edvinsson, Lars
openaire   +3 more sources

Pain pharmacology in migraine: focus on CGRP and CGRP receptors

Neurological Sciences, 2007
Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin generelated peptide (CGRP) and its receptors (CGRP-R) because of their role in ...
BENEMEI, SILVIA, NICOLETTI, PAOLA, J. A. Capone, GEPPETTI, PIERANGELO   +3 more
openaire   +3 more sources