Results 71 to 80 of about 33,931 (282)

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Impact of Galcanezumab on Total Pain Burden: A Post Hoc Analysis of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study in Patients with Episodic Cluster Headache

Journal of Pain Research, 2021
J Scott Andrews,1 David Kudrow,2 Mallikarjuna Rettiganti,1 Tina Oakes,1 Jennifer N Bardos,1 Richard Wenzel,1 Dulanji K Kuruppu,1 Charly Gaul,3 James M Martinez1 1Eli Lilly and Company, Indianapolis, IN, USA; 2California Medical Clinic for Headache, Santa
Andrews JS, Kudrow D, Rettiganti M, Oakes T, Bardos JN, Wenzel R, Kuruppu DK, Gaul C, Martinez JM   +8 more
doaj  

CGRP or CGRP_8–37 administration did not influence plasma TRAP5b in vivo.

, 2013
Plasma concentrations of CGRP and TRAP5b, normalized to plasma total protein, 10 days after fatigue loading. (A) Rats in the CGRP group had higher plasma CGRP concentrations when compared to rats in the Saline and CGRP8–37 groups.
Susannah J. Sample (308203), Zhengling Hao (308207), Aliya P. Wilson (350146), Peter Muir (308211)   +3 more
core   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Efficacy of fremanezumab in patients with chronic migraine and concomitant depression

Клинический разбор в общей медицине
Background. Migraine is a common chronic disorder that ranks third in the disability-adjusted life years among nervous system disorders. It is well known that migraine is strongly associated with the depression/anxiety disorders; there is overwhelming ...
A.Y. Timokhovich , A.V. Berdnikova, N.V. Latysheva   +2 more
doaj   +1 more source

Eptinezumab for the Prevention of Migraine: Clinical Utility, Patient Preferences and Selection – A Narrative Review

Therapeutics and Clinical Risk Management, 2023
Claudia Altamura,1,2 Nicoletta Brunelli,1,2 Marilena Marcosano,1,2 Alessandro Alesina,1,2 Luisa Fofi,1,2 Fabrizio Vernieri1,2 1Fondazione Policlinico Universitario Campus Bio-Medico, Roma, 00128, Italy; 2Unit of Headache and Neurosonology, Department of ...
Altamura C, Brunelli N, Marcosano M, Alesina A, Fofi L, Vernieri F   +5 more
doaj  

Tear Fluid Calcitonin Gene-Related Peptide Levels Are Elevated in Glycerol Trinitrate-Induced Cluster Headache Attacks: Results From an Exploratory Study. [PDF]

Eur J Neurol
Cluster headache (CH) is a severe primary headache disorder and the neuropeptide calcitonin gene‐related peptide (CGRP) has been shown to be elevated ictally and interictally. We investigated tear fluid CGRP levels during experimental cluster headache attacks and showed elevated CGRP levels during these headache attacks.
Kamm K, Angelhuber M, Le Prince AM, Straube A, Ruscheweyh R.   +4 more
europepmc   +2 more sources

Cancer-related pain: A bidirectional modulator of cancer progression. [PDF]

Clin Transl Med
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
He J, Zhang Y, Liu Q, Yan B, Chai P, Jia R.   +5 more
europepmc   +2 more sources

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source