Results 81 to 90 of about 33,931 (282)

Is CGRP a marker for chronic migraine?

, 2013
Calcitonin gene-related peptide (CGRP) research was initiated by Poyner et al.,(1) who found that the calcitonin gene encodes the 37-amino acid neuropeptide CGRP in neuronal tissue.
Edvinsson, Lars, Silberstein, Stephen D
core   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Ubrogepant in the Acute Management of Migraine: A Narrative Review

Journal of Pain Research, 2021
Chia-Chun Chiang,1 Juliana H VanderPluym2 1Department of Neurology, Mayo Clinic, Rochester, MN, USA; 2Department of Neurology, Mayo Clinic, Scottsdale, AZ, USACorrespondence: Juliana H VanderPluym Email vanderpluym.juliana@mayo.eduAbstract: Ubrogepant is
Chiang CC, VanderPluym JH
doaj  

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Clinical Pharmacology &Therapeutics, EarlyView.
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Alice Ke, Ernesto Callegari, Manthena V.S. Varma, Mayur K Ladumor, Chieko Muto, Richard J. Bertz, Hannah M. Jones, Vaishali Sahasrabudhe, Jing Liu   +8 more
wiley   +1 more source

A Novel Rat Model to Study Postsurgical Pain After Joint Replacement Surgery

Journal of Pain Research, 2022
Naoki Aoyama, Masashi Izumi, Toru Morimoto, Hiroyuki Wada, Junpei Dan, Yusuke Kasai, Yoshinori Satake, Koji Aso, Masahiko Ikeuchi Department of Orthopedic Surgery, Kochi Medical School, Kochi University, Nankoku, JapanCorrespondence: Masashi Izumi ...
Aoyama N, Izumi M, Morimoto T, Wada H, Dan J, Kasai Y, Satake Y, Aso K, Ikeuchi M   +8 more
doaj  

Could calcitonin gene‐related peptide inhibitors prevent status epilepticus?

Epilepsia, EarlyView.
Abstract Calcitonin gene‐related peptide (CGRP) inhibitors modulate pain and neuroinflammation, a recognized contributor to epileptogenesis and status epilepticus (SE). We examined the association between CGRP inhibitor use and SE hospitalization in epilepsy patients with comorbid migraine.
Michael Nsaka, Noor Baban, Sepideh Allahdadian, Armin Scheffler, Diana Lindner, Dagny Holle, Alain Lekoubou   +6 more
wiley   +1 more source

Effectiveness of Switching CGRP Monoclonal Antibodies in Non-Responder Patients in the UAE: A Retrospective Study

Neurology International
Calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) have shown promising effectiveness in migraine management compared to other preventative treatment options.
Reem Suliman, Vanessa Santos, Ibrahim Al Qaisi, Batool Aldaher, Ahmed Al Fardan, Hajir Al Barrawy, Yazan Bader, Jonna Lyn Supena, Kathrina Alejandro, Taoufik Alsaadi   +9 more
doaj   +1 more source

Evaluation of mRNA Expression of Calcitonin Gene-Dependent Peptide (CGRP) and Rat Calcitonin (rCT) in the Periaqueductal Gray Area (PAG) of Diabetic Rats in the Formalin Test

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2022
Introduction: CGRP and rCT are involved in descending pain control areas. This study aimed to evaluate the effect of intracerebroventricular administration (ICV) of CGRP and rCT on mRNA expression of CGRP and rCT peptides in the Periaqueductal Gray Area (
Olya Moshiri, Javad Sajedianfard, Saeid Hosseinzadeh, Kaveh Rahimi, Saeedeh Ahmadi Jokani   +4 more
doaj  

Progress in the Role of Mast Cells and Biomolecular Signals in the Mechanism of Postoperative Ileus: From Cellular Activation to Exploration of the Brain–Gut Axis

Gut Medicine, EarlyView.
ABSTRACT Postoperative ileus (POI) is a frequent complication after surgical procedures, predominantly manifesting as aberrant gastrointestinal motility, which markedly extends the duration of postoperative recovery for patients. The clinical duration of POI is typically modulated by intricate inflammatory cascades, with mast cells assuming a critical ...
Tian‐le Zhang, Miao‐ying Geng, Ming‐yue Shao, Gang Wang, Zhi‐wei Jiang   +4 more
wiley   +1 more source