Results 101 to 110 of about 33,931 (282)
Journal of Pain ResearchRichard B Lipton,1 Alexandra Thiry,2 Beth A Morris,3 Robert Croop3 1Department of Neurology and the Montefiore Headache Center, Albert Einstein College of Medicine, Bronx, NY, USA; 2Biostatistics, Pfizer, Inc., New York, NY, USA; 3Clinical Operations (BM)
Lipton RB, Thiry A, Morris BA, Croop R
doaj
, 2008 This paper presents an investigation on wear and friction characteristics of chopped strand mat (CSM) glass fibres 450g/m(2) reinforced polyester (CGRP) composite under wet contact condition against polished stainless steel counterface.
Yousif, B. F. +3 more
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Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis
Allergy, EarlyView.Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross +11 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro +14 more
wiley +1 more source
The Journal of Headache and Pain, 2019 Background Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches.
Raffi Manoukian +5 more
doaj +1 more source
Amylin and CGRP induce insulin resistance via a receptor distinct from cAMP-coupled CGRP receptor
, 1993 Amylin and calcitonin gene-related peptide (CGRP) inhibited insulin-stimulated 2-deoxyglucose uptake in L6 myocytes and isolated soleus muscle. Both peptides were maximally active at 10 pM in L6 cells and inhibited insulin action by 40-50%.
D. K. Kreutter +5 more
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Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley +1 more source
Distribution of CGRP and CGRP receptor in the trigeminovascular system and CNS
, 2013 Calcitonin gene-related peptide (CGRP) has a key role in the pathophysiology of migraine and is associated with activation of the trigeminovascular system. Recently, CGRP receptor antagonists have been developed with clinical efficacy. The present thesis
Eftekhari, Sajedeh,, Lund University.
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