Results 121 to 130 of about 45,236 (268)

A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure

Frontiers in Pharmacology
BackgroundAlpha-calcitonin gene-related peptide (α-CGRP) is a cardioprotective neuropeptide. However, due to low bioavailability, its use as a therapeutic agent is limited.
Ambrish Kumar, Sarah Deloach, Lernix Williams, Donald J. DiPette, Jay D. Potts   +4 more
doaj   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]

, 2019
Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song, Gao, Derek, Gaut, Joseph, Hoshi, Masato, Jain, Sanjay, Kim, Eric H., Knoten, Amanda, Lake, Blue B., Plongthongkum, Nongluk, Salamon, Diane, Venkatesh, Ramakrishna, Vijayan, Anitha, Zhang, Kun   +12 more
core   +2 more sources

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Capsaicin-Induced Ca2+ Influx and Constriction of the Middle Meningeal Artery [PDF]

, 2014
Research in the past on transient receptor potential cation channel subfamily V member 1 (TRPV1) has been limited to mainly nervous tissue TRPV1 because of the channel’s role in pain perception.
Koide, Masayo, Kotlikoff, Michael I., Manuelyan, Inessa, Shui, Bo, Syed, Arsalan U., Wellman, George C.   +5 more
core   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Sex differences in the effects of calcitonin gene-related peptide signaling on migraine-like behavior in animal models: a narrative review

Frontiers in Neurology
Migraine is a common neurological disorder with a typical onset in adolescence or early adulthood. Migraine is three times more common in women than men, but the definitive cause underlying the observed disparity is not fully understood.
Lakeisha A. Lewter, Rachel L. Arnold, Nina B. Narosov, Gregory Dussor, Benedict J. Kolber   +4 more
doaj   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source