Results 121 to 130 of about 33,931 (282)

Real‐world outcomes of zavegepant use in a tertiary care setting using the Migraine Treatment Optimization Questionnaire‐5

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background The introduction of calcitonin gene‐related peptide antagonists has transformed migraine care. Zavegepant, a third‐generation intranasal gepant, offers a nonoral treatment option for acute migraine. Although clinical trials support its efficacy and safety, real‐world data are limited.
Eric Dunn, Bradley Ong, Harpreet Kaur, Roman Popov, Claire Sonneborn, Aarushi Suneja   +5 more
wiley   +1 more source

The diagnostic order of migraine–depression comorbidity associates with physical, mental, and social disability

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background There is a known bidirectional association between migraine and depression; however, potential effects of the diagnostic trajectory of the diseases are not known. Therefore, we investigated the association of the diagnostic order of migraine and depression with the physical and mental health status of groups with ...
Daniel Baksa, Nora Eszlari, Dora Torok, Tamas Nagy, Gabor Hullam, Peter Petschner, Gyorgy Bagdy, Gabriella Juhasz   +7 more
wiley   +1 more source

A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure

Frontiers in Pharmacology
BackgroundAlpha-calcitonin gene-related peptide (α-CGRP) is a cardioprotective neuropeptide. However, due to low bioavailability, its use as a therapeutic agent is limited.
Ambrish Kumar, Sarah Deloach, Lernix Williams, Donald J. DiPette, Jay D. Potts   +4 more
doaj   +1 more source

Responding With Evidence and Access for Childhood Headaches (REACH) study: A comparative effectiveness trial of cognitive behavioral therapy monotherapy versus combined cognitive behavioral therapy–pharmacotherapy with amitriptyline for the prevention of childhood migraine—The study protocol

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Migraine is one of the most common chronic health problems in children and adolescents, resulting in high levels of functional disability. Symptoms frequently persist into and impact the course of adulthood for affected individuals. Current practice recommendations include a combined therapy approach of preventive medication and cognitive ...
Estée C. H. Feldman, Michelle M. Ernst, Maya A. Marzouk, Robert C. Gibler, Brooke L. Reidy, Leigh A. Chamberlin, Megan Kirschman, James Peugh, Marielle Kabbouche, Susan L. LeCates, Joanne Kacperski, Jessica A. Saunders, Andrew D. Hershey, Marcy E. Yonker, Christina L. Szperka, Amy A. Gelfand, Scott W. Powers, on behalf of the REACH Study Investigators, Joanne Kacperski, Jennifer McVige, Frank Berenson, Chaouki Khoury, Judy Adelizzi‐Delany, Marcy Yonker, Elizabeth Ackley, J. Ivan Lopez, Ann Pakalnis, Sara Pavitt, Scott Turner, Elizabeth Doll, Michael Sowell, Rachel Evans, Lauren Evanczyk, Reena Rastogi, Amy Gelfand, Hannah Shapiro, Christina Szperka, Ankita Gosh, Rashmi Rao   +38 more
wiley   +1 more source

Evaluation of expression and function of opioid receptors in Schwann cells

openLe cellule di Schwann (SC) sembrano essere coinvolte nei meccanismi di sviluppo dell'emicrania in quanto studi precedenti hanno dimostrato l'espressione del recettore per il Calcitonin Gene-Related Peptide (CGRP), ligando responsabile dell'attacco ...
NARDELLO, RICCARDO
core  

Personalized machine learning prediction of next‐day migraine persistence using digital headache diary data

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Migraine is a disabling neurological disorder with substantial interindividual variability. Predicting whether an ongoing migraine attack will persist into the following day remains challenging. We evaluated the feasibility and predictive performance of personalized machine learning models for predicting next‐day migraine
Ya‐Hsiu Tsai, Chen‐Lin Chiou, Jun‐Jun Lee, Chun‐Ming Yang, Kao‐Chang Lin, Tain‐Junn Cheng, Ja‐Hwung Su, Cheng‐Hsin Chuang   +7 more
wiley   +1 more source

Parabrachial calcitonin gene-related peptide neurons sex-specifically modulate behavior in anxiety assays during alcohol withdrawal

Frontiers in Pharmacology
Parabrachial nucleus (PBN) neurons expressing Calcitonin Gene-Related Peptide (CGRP) modulate fear- and anxiety-like behavior. It is unknown if PBN(CGRP) neurons play a role in anxiety during withdrawal from alcohol or after repeated stress.
C. E. Van Doorn, C. E. Van Doorn, J. B. Tyree, J. B. Tyree, A. A. Jaramillo, A. A. Jaramillo, A. A. Jaramillo, A. A. Jaramillo, A. A. Jaramillo, A. A. Jaramillo   +9 more
doaj   +1 more source

Targeted liquid chromatography–tandem mass spectrometry profiling of arginine and histidine derivatives in chronic migraine: Discriminatory performance and changes after onabotulinumtoxinA therapy

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary People with chronic migraine may have changes in amino‐acid metabolism, but it remains unclear which metabolic pathways are associated with the disease and early response to onabotulinumtoxinA treatment. We measured plasma amino‐acid levels in patients with chronic migraine and healthy controls and assessed changes after 1 month ...
Seyma Dumur, Kadidiatou Diarra, Joudy Sewidan, Julie Jalila Kalmoni, Demet Aygun, Dildar Konukoglu, Hafize Uzun   +6 more
wiley   +1 more source

CGRP expression in DRG neurons.

, 2013
Representative images of the same DRG section labeled with CGRP (A), IB4 (B), FG (C), CGRP and FG (D), IB4 and FG (E), and stained with fluorescent Nissl (F).
Fengxiang Liu (509644), Degang Yu (586377), Ming Liu (105953), Xiaoqing Wang (514179), Xin Zhao (71840), Yuanqing Mao (509643), Zhenan Zhu (460370), Yang Li (7082)   +7 more
core   +1 more source

The Expression of Neuropeptides in Pulpitis: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background Neuropeptides play key roles in the inflammatory, nociceptive and reparative processes of the dental pulp. Their upregulation has been frequently observed in inflamed pulps, suggesting potential diagnostic value supporting a role for neurogenic inflammation in symptomatic irreversible pulpitis.
N. Watson, D. Edwards, Q. Vuong, I. Obara   +3 more
wiley   +1 more source