Results 131 to 140 of about 119,789 (252)

Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

Aging Cell, Volume 25, Issue 5, May 2026.
In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula, Anjaly KM, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N. Chini, Heather M. Gibson, Ramandeep Rattan   +10 more
wiley   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, Volume 36, Issue 3, May 2026.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

Brain Pathology, Volume 36, Issue 3, May 2026.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García, Jorge Mena, Carol‐Ann Lao, David Adamuz, Laura Arnaldo, Cristina Carrato, Alex Menendez, Daniela Samaniego, Dolores Vilas, Lourdes Ispierto, Anna Planas, Ramiro Alvarez, Pau Pastor, Katrin Beyer   +13 more
wiley   +1 more source

Targeting mitocytosis potentiates mitochondria drug delivery for antimetastasis therapy. [PDF]

Sci Adv
Deng Y, Zhang Y, Jia F, Jiang P, Li L, Huang Y.   +5 more
europepmc   +1 more source

Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness

Genes to Cells, Volume 31, Issue 3, May 2026.
COP1 promotes HCC lipid metabolism and stemness via the functional interaction with AKR1D1 and TMEM65 genes, respectively, indicating its potential as a therapeutic target for treating primary HCC and preventing metastasis and/or recurrence. ABSTRACT We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic ...
Eun‐Hye Jeon, An‐Na Bae, Hajin Lee, Keon Uk Park, Hyun Mu Shin, Jong Ho Park, Kwang Seok Kim, In‐Chul Park, Yun‐Han Lee   +8 more
wiley   +1 more source

Returns after personal tax on UK equity and gilts, 1919-98 [PDF]

, 2004
Armitage, Seth
core   +1 more source

Neither Black Enough nor White Enough: An Intersectional Perspective on the Lived Experiences of Colored Women Leaders in Postapartheid South Africa

Gender, Work &Organization, Volume 33, Issue 3, Page 858-869, May 2026.
ABSTRACT This article seeks to disrupt the undertheorization of Colored women's leadership experiences in gender transformation research. We refer specifically to women who self‐identify as Colored South African and consider themselves to be part of the South African Colored community.
Trudy Rhoda Forbay, Peliwe Pelisa Mnguni
wiley   +1 more source

Tropical volcanism triggers pan-Asian monsoon droughts via circumglobal teleconnection. [PDF]

Nat Commun
Nie W, Xia J, Kino K, She D, Oki T.
europepmc   +1 more source

Uneven Product Diversification: Explaining the Lag of Agricultural Economies

International Economic Review, Volume 67, Issue 2, Page 581-604, May 2026.
ABSTRACT This paper documents that agricultural sectors diversify less than other manufacturing activities. A simple model shows that this difference can contribute to welfare divergence in a way that is qualitatively different to what results when uneven growth happens in the intensive margin.
Guzmán Ourens
wiley   +1 more source

Executive and motivational pathways to ADHD traits in the general population: a structural equation model of working memory, attention, delay discounting, and decision-making. [PDF]

BMC Psychol
Ikegami M, Sorama M, Katayama A, Omiya H.   +3 more
europepmc   +1 more source