Results 31 to 40 of about 4,937,084 (227)
The Anatomical Record, EarlyView.Abstract Studies investigating paleopathologies in sauropods remain scarce despite their relative abundance in the fossil record. In this study we report new occurrence of paleopathological features, corresponding to a neoplasm found in a middle caudal vertebra (MCT.R.2120) of an advanced titanosaur from the Presidente Prudente Formation (Bauru Basin ...
Maria Luiza Peres Bertolossi +5 more
wiley +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source
Revista Chilena de Historia Natural, 2021 The source of Darwin’s illness has been a contentious issue in the literature for almost 70 years. Different causal factors have been invoked to account for his symptoms, including Chagas disease.
Carezza Botto-Mahan, Rodrigo Medel
doaj +1 more source
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
CrAg screening strategy reduces definitive sequelae in people living with HIV
Discover VirusesBackground Screenning cryptococcal antigen (CrAg) of people living with HIV (PLHIV) reduces the morbidity and development of cryptococcal meningitis, but recent publications shows that it does not reduce mortality when comparable with a negative CrAg ...
Marcela de Faria Ferreira +4 more
doaj +1 more source
Annals of Hepatology, 2017 Background Cirrhosis remains the most frequent liver-related cause of death worldwide and we aimed to evaluate its burden in Brazil from 2000 to 2012.Material and methods The Brazilian National Death Registry was analyzed from 2000 to 2012.
Hugo Perazzo +7 more
doaj +1 more source
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. [PDF]
, 2010 Oxidative stress is common in inflammatory processes associated with many diseases including Chagas' disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant ...
Olindo Assis Martins-Filho +30 more
core +1 more source
Clinical Advances in Periodontics, EarlyView.Abstract Background Conventional envelope flap techniques for implant placement in edentulous mandibles are associated with greater postoperative morbidity, especially in elderly patients or those with anatomical limitations. Minimally invasive alternatives aim to preserve soft tissues and reduce complications, enhancing clinical predictability ...
Lucas Jardim da Silva +5 more
wiley +1 more source
Frontiers in MedicineBackgroundA better understanding of the consequences of the Coronavirus Disease 2019 (COVID-19) pandemic on lifestyle of patients with Chagas disease (ChD) is of paramount importance to facilitate the implementation of intervention strategies tailored to
Isis Gabrielli Gomes Xavier +22 more
doaj +1 more source
Synthesis of Naphthoquinones by Pd‐Catalyzed Heck–Matsuda Arylation of Lapachol
European Journal of Organic Chemistry, EarlyView.Direct Heck–Matsuda arylation of lapachol enables the efficient synthesis of diverse naphthoquinones under homogeneous and heterogeneous palladium catalysis. The methodology features broad substrate scope, gram‐scale applicability, and provides a practical platform for quinone diversification.
Breno U. de Abreu +13 more
wiley +1 more source