Circulating microRNAs as biomarkers of Chagas cardiomyopathy [PDF]
Frontiers in Cardiovascular Medicine, 2023 BackgroundChagas cardiomyopathy (CHCM) is the most important clinical manifestation of Chagas disease. The analysis of cardiac miRNAs may contribute to predicting the progression to CHCM in Chagas indeterminate phase and/or to the differential diagnosis ...
Laura Antonietti +13 more
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Determinants of minute ventilation-carbon dioxide production relationship in Chagas cardiomyopathy
Revista da Sociedade Brasileira de Medicina Tropical, 2021 INTRODUCTION: The minute ventilation-carbon dioxide production relationship (VE/VCO2 slope) is among the main prognostic factors of Chagas cardiomyopathy whose determinants remain unknown. METHODS: Seventy-eight patients with Chagas cardiomyopathy were
Lucas Frois Fernandes Oliveira +9 more
doaj +2 more sources
Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy
Hearts, 2023 Cardiomyopathies are major causes of heart failure. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central and South America.
Frédéric Gallardo +39 more
doaj +2 more sources
Prognostic value of the New York Heart Association classification for cardiovascular events and mortality in Chagas cardiomyopathy: a systematic review and meta-analysis with GRADE recommendations [PDF]
Revista da Sociedade Brasileira de Medicina TropicalChagas cardiomyopathy is associated with a higher risk of severe cardiovascular events and increased mortality. Among the factors associated with Chagas cardiomyopathy, impairment in functional capacity-commonly assessed using the New York Heart ...
Whesley Tanor Silva +9 more
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Echocardiographic predictors of mortality in heart failure from Chagas cardiomyopathy: Refining risk stratification with speckle-tracking echocardiography [PDF]
American Heart Journal PlusBackground: Chagas cardiomyopathy is a major cause of mortality in endemic regions, predicted primarily by left ventricular (LV) systolic function. Speckle-tracking echocardiography (STE)–derived strain is a sensitive tool for assessing ventricular ...
Marcelo Alves Maia +10 more
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Stroke in Chagas disease: from pathophysiology to clinical practice [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2022 Despite substantial progress toward its control, Chagas disease continues to be a major public health problem in Latin America and has become a global health concern.
Thaís Aparecida Reis Lage +6 more
doaj +1 more source
Therapeutic Advances in Infectious Disease, 2022 Approximately 300,000 people in the United States are estimated to have Chagas’ disease, with cardiac manifestations including arrhythmias occurring in 20%–30% of patients.
Devang R. Amin +8 more
doaj +1 more source
Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease. [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Myocardium damage during Chagas' disease results from the immunological imbalance between pro- and production of anti-inflammatory cytokines and has been explained based on the Th1-Th2 dichotomy and regulatory T cell activity.
Paulo Marcos Matta Guedes +11 more
doaj +1 more source
Stroke correlates in chagasic and non-chagasic cardiomyopathies. [PDF]
PLoS ONE, 2012 BACKGROUND: Aging and migration have brought changes to the epidemiology and stroke has been shown to be independently associated with Chagas disease.
José Alberto Martins da Matta +4 more
doaj +1 more source
Journal of Cardiovascular Magnetic Resonance, 2022 Background Although Chagas cardiomyopathy is related to thromboembolic stroke, data on risk factors for cerebrovascular events in Chagas disease is limited.
Henrique Turin Moreira +6 more
doaj +1 more source