Results 21 to 30 of about 5,576 (168)

Chagas cardiomyopathy: Europe is not spared! [PDF]

European Heart Journal, 2008
Chagas’ disease was first described in 1909 by the Brazilian physician Carlos Chagas, who named the parasite Trypanosoma cruzi after his mentor, Oswaldo Cruz.1 It causes more deaths in the Americas than any other parasitic disease.1 Due to the parasite distribution throughout Central and South America, it is commonly known as the ‘American ...
Guerri Guttemberg R, Grana DR, AMBROSIO, Giuseppe, Milei J.   +3 more
openaire   +2 more sources

Evaluation of the six-minute walk test in patients with chronic heart failure associated with Chagas' disease and systemic arterial hypertension Avaliação do teste de caminhada de seis minutos em pacientes com insuficiência cardíaca crônica associada à doença de Chagas e hipertensão arterial sistêmica

Revista da Sociedade Brasileira de Medicina Tropical, 2010
INTRODUCTION: To evaluate physical capacity as determined by the six-minute walk test (6MWT) in patients with chronic heart failure due to Chagas' disease associated with systemic arterial hypertension (Chagas-SAH).
Kelly Cristina Colaço Dourado, Reinaldo Bulgarelli Bestetti, Augusto Cardinalli-Neto, José Antônio Cordeiro   +3 more
doaj   +1 more source

Scientometrics analysis of research activity and collaboration patterns in Chagas cardiomyopathy. [PDF]

PLoS Neglected Tropical Diseases, 2018
Chagas cardiomyopathy is a serious and common complication of Chagas disease.Through bibliometric and Social Network Analysis, we examined patterns of research on Chagas cardiomyopathy, identifying the main countries, authors, research clusters, and ...
Gregorio González-Alcaide, Alejandro Salinas, José M Ramos   +2 more
doaj   +1 more source

CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy [PDF]

Memorias do Instituto Oswaldo Cruz
We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi.
Germano Carneiro Costa, Manoel Otávio da Costa Rocha, Paulo Eduardo Alencar de Souza, Diego Felipe SA Melo, Paula Rocha Moreira, Kenneth John Gollob, Maria do Carmo Pereira Nunes, Walderez Ornelas Dutra   +7 more
doaj   +2 more sources

Developments in the management of Chagas cardiomyopathy [PDF]

Expert Review of Cardiovascular Therapy, 2015
Over 100 years have elapsed since the discovery of Chagas disease and there is still much to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs available, such as benznidazole and nifurtimox, they are not totally reliable and often toxic.
Herbert B, Tanowitz, Fabiana S, Machado, David C, Spray, Joel M, Friedman, Oren S, Weiss, Jose N, Lora, Jyothi, Nagajyothi, Diego N, Moraes, Nisha Jain, Garg, Maria Carmo P, Nunes, Antonio Luiz P, Ribeiro   +10 more
openaire   +2 more sources

Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy.

PLoS ONE, 2018
Tyrosine kinase 2 (TYK2) is a member of the Janus kinases family implicated in the signal transduction of type I interferons and several interleukins. It has been described that genetic mutations within TYK2 lead to multiple deleterious effects in the ...
Daniel A Leon Rodriguez, Marialbert Acosta-Herrera, F David Carmona, Nuria Dolade, Sofia Vargas, Luis Eduardo Echeverría, Clara Isabel González, Javier Martin   +7 more
doaj   +1 more source

Increases in [IP3]i aggravates diastolic [Ca2+] and contractile dysfunction in Chagas' human cardiomyocytes.

PLoS Neglected Tropical Diseases, 2020
Chagas cardiomyopathy is the most severe manifestation of human Chagas disease and represents the major cause of morbidity and mortality in Latin America.
Alfredo Mijares, Raúl Espinosa, José Adams, José R Lopez   +3 more
doaj   +1 more source

Chagas disease and systemic autoimmune diseases among Bolivian patients in Switzerland

Memorias do Instituto Oswaldo Cruz, 2018
BACKGROUND Chronic cardiomyopathy occurs in 20-40% of the patients with Chagas disease. Autoimmune mechanisms may contribute to its pathogenesis. We diagnosed several cases of systemic autoimmune diseases among Bolivian migrants in Geneva with a high ...
Yves Jackson, Drenusha Vieira de Mello Pula, Axel Finckh, Carlo Chizzolini, François Chappuis   +4 more
doaj   +1 more source

Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial

Memorias do Instituto Oswaldo Cruz
Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America.
Anis Rassi Jr, José Antonio Marin Neto, Anis Rassi   +2 more
doaj   +1 more source

Mortality risk in chronic Chagas cardiomyopathy: a systematic review and meta‐analysis

ESC Heart Failure, 2021
Aims This study aimed to estimate the annual mortality risk and its determinants in chronic Chagas cardiomyopathy. Methods and results We conducted a systematic search in MEDLINE, Web of Science Core Collection, Embase, Cochrane Library, and LILACS ...
Sindhu Chadalawada, Anis Rassi Jr, Omar Samara, Anthony Monzon, Deepika Gudapati, Lilian Vargas Barahona, Peter Hyson, Stefan Sillau, Luisa Mestroni, Matthew Taylor, Maria daConsolação Vieira Moreira, Kristen DeSanto, Nelson I. Agudelo Higuita, Carlos Franco‐Paredes, Andrés F. Henao‐Martínez   +14 more
doaj   +1 more source