Results 41 to 50 of about 5,576 (168)

Clinical and echocardiographic predictors of mortality in chagasic cardiomyopathy - systematic review

Arquivos Brasileiros de Cardiologia, 2014
Diagnosis, prognosis and evaluation of death risk in Chagas cardiomyopathy still constitute a challenge due to the diversity of manifestations, which determine the importance of using echocardiography, tissue Doppler and biomarkers. To evaluate, within a
Clodoval de Barros Pereira Júnior, Brivaldo Markman Filho   +1 more
doaj   +1 more source

Current Topics of Progressive Cardiac Conduction Disease

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Many genes and the protein cause PCCD. Mutation of NaV1.5 or CX40 cause isolated PCCD, but mutation of lamin A/C, emerin, or desmin lead to cardiomyopathy, and PCCD. Mutation of transcription factor NCX2‐5, and Tbx5 associated with atrial septal defect and abnormal development of conduction system.
Naokata Sumitomo, Hitoshi Mori, Takashi Kumamoto, Taisuke Ishikawa, Akiko Seki, Naomasa Makita, Jean‐Jacques Schott, Arthur A. M. Wilde   +7 more
wiley   +1 more source

Opportunities and Challenges in Chronic Chagas Cardiomyopathy [PDF]

Global Heart, 2015
Chronic Chagas cardiomyopathy (CCC) is the most serious complication of Chagas disease. More than a century after the astute clinician-scientist Carlos Chagas published the etiologic, pathological, clinical, and epidemiological characteristics of the disease that now bears his name [1], much scientific progress has been made.
Mensah, George A., Burns, Kristin M., Peprah, Emmanuel K., Sampson, Uchechukwu K.A., Engelgau, Michael M.   +4 more
openaire   +3 more sources

Chagas cardiomyopathy

Heart
Chagas cardiomyopathy, caused by chronic infection with Trypanosoma cruzi , is a leading cause of non-ischaemic heart failure in Latin America and is increasingly recognised worldwide due to migration.
Maria Carmo Pereira Nunes, Antonio Luiz Pinho Ribeiro, Walderez Dutra, Gustavo Araujo Silva, Andre A L Carmo, Fernando Antonio Botoni, Israel Molina, Ester Sabino, Caryn Bern   +8 more
openaire   +3 more sources

Pathogenesis of chronic Chagas cardiomyopathy: the role of coronary microvascular derangements

Revista da Sociedade Brasileira de Medicina Tropical, 2013
There is ample experimental and clinical evidence of functional and structural microvascular abnormalities occurring in patients with Chagas cardiomyopathy, possibly due to the inflammatory process and/or autonomic disturbances caused by Trypanosoma ...
Jose Antonio Marin-Neto, Marcus Vinicius Simoes, Anis Rassi Junior   +2 more
doaj   +1 more source

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

Phytotherapy Research, Volume 40, Issue 5, Page 2878-2894, May 2026.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng, Mingyang He, Haiying Wu, Tianjie Zhang, Yuxia Jiang, Chuanwei Xin, Meiling Zhang, Jiaqi He, Lulu Zheng   +8 more
wiley   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, Volume 183, Issue 10, Page 2256-2272, May 2026.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.
Matheus Barbosa de Miranda, Adriene Siqueira de Melo, Mariana Silva Almeida, Silvia Martins Marinho, Wilson Oliveira Junior, Yara de Miranda Gomes   +5 more
doaj   +1 more source

Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga

Revista do Instituto de Medicina Tropical de São Paulo, 2008
Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy ...
Angelina M.B. Bilate, Edecio Cunha-Neto
doaj   +1 more source

Deriving a parsimonious cardiac endpoint for use in epidemiological studies of Chagas disease: results from the Retrovirus Epidemiology Donor Study-II (REDS-II) cohort

Revista do Instituto de Medicina Tropical de São Paulo, 2021
Chagas cardiomyopathy (ChCM) is a severe consequence of Trypanosoma cruzi infection and has a range of electrocardiographic (ECG) and echocardiographic (ECHO) manifestations. There is a need for a standard and parsimonious research cardiac end point that
Lewis F. Buss, Taniela Marli Bes, Alexandre Pereira, Larissa Natany, Claudia Di Lorenzo Oliveira, Antonio Luiz P Ribeiro, Ester Cerdeira Sabino   +6 more
doaj   +1 more source