Results 61 to 70 of about 5,576 (168)

Lycopene's Role in Mitigating Obesity‐Induced Cardiac Remodeling: Insights Into Inflammatory and MMP‐2 Pathways

Molecular Nutrition &Food Research, Volume 70, Issue 2, 29 January 2026.
A. Consumption of a highsugar‐fat diet causes excess nutrients, hypertrophy and hyperplasia of adipocytes, causing obesity. Obesity leads to increased inflammatory levels in the heart, which stimulates greater activation of Metalloproteinase‐2 (MMP‐2), which has collagenolytic activity, degrading the collagen network in the heart, ultimately causing ...
Carol Cristina Vagula de Almeida de Silva, Artur Junio Togneri Ferron, Fabiane Valentini Francisqueti‐Ferron, Alexandre Ribeiro da Silva, Silmeia Garcia Zanati Bazan, Jéssica Leite Garcia, Dijon Henrique Salomé de Campos, Mariane Róvero Costa, Daniele Dantas, Heloysa Amaral da Silva, Janaina Paixão das Chagas Silva, Giselle Pinto Faria de Lopes, Bertha Furlan Polegato, Camila Renata Correa, Fernando Moreto, Ana Lucia Anjos Ferreira   +15 more
wiley   +1 more source

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley   +1 more source

Activation of Human CD11b+ B1 B-Cells by Trypanosoma cruzi-Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease

Frontiers in Immunology, 2019
B-cells mediate humoral adaptive immune response via the production of antibodies and cytokines, and by inducing T-cell activation. These functions can be attributed to distinct B-cell subpopulations. Infection with Trypanosoma cruzi, the causative agent
Livia Silva Araújo Passos, Livia Silva Araújo Passos, Luísa Mourão Dias Magalhães, Luísa Mourão Dias Magalhães, Rodrigo Pinto Soares, Rodrigo Pinto Soares, Alexandre F. Marques, Marina Luiza Rodrigues Alves, Rodolfo Cordeiro Giunchetti, Rodolfo Cordeiro Giunchetti, Maria do Carmo Pereira Nunes, Kenneth J. Gollob, Kenneth J. Gollob, Walderez Ornelas Dutra, Walderez Ornelas Dutra, Walderez Ornelas Dutra   +15 more
doaj   +1 more source

Risk Score for Predicting 2‐Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi‐Trop Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Risk stratification of Chagas disease patients in the limited‐resource setting would be helpful in crafting management strategies. We developed a score to predict 2‐year mortality in patients with Chagas cardiomyopathy from remote endemic ...
Claudia Di Lorenzo Oliveira, Maria Carmo P. Nunes, Enrico Antonio Colosimo, Emilly Malveira de Lima, Clareci S. Cardoso, Ariela Mota Ferreira, Lea Campos de Oliveira, Carlos Henrique Valente Moreira, Ana Luiza Bierrenbach, Desireé Sant′Ana Haikal, Sérgio Viana Peixoto, Maria Fernanda Lima‐Costa, Ester Cerdeira Sabino, Antonio Luiz P. Ribeiro   +13 more
doaj   +1 more source

Sex in Immune Cells and Parasitic Diseases — A Complex Relationship

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Epidemiological studies consistently show that many parasitic diseases affect males more frequently than females. These disparities are multifactorial, arising partly from gender‐specific behaviors that influence exposure risk and health‐seeking practices, especially in low‐ and middle‐income countries. Increasing evidence also highlights that
Barbara Honecker, Charlotte Sophie Hansen, Hanna Lotter   +2 more
wiley   +1 more source

Association between positive serology for COVID-19 and chagas cardiomyopathy progression: The SaMi-Trop project

Travel Medicine and Infectious Disease
Background: Chagas Disease (CD) can cause Chagas cardiomyopathy. The new coronavirus disease (COVID-19) also affects the cardiovascular system and may worsen Chagas cardiomyopathy.
Ariela Mota Ferreira, Léa Campos Oliveira-da Silva, Clareci Silva Cardoso, Cláudia Di Lorenzo Oliveira, Bruno Oliveira de Figueiredo Brito, Ana Luiza Bierrenbach, Ana Clara de Jesus Santos, Dardiane Santos Cruz, Sâmara Fernandes Leite, Andréia Brito Jesus, Renata Fiúza Damasceno, Maria Carmo Pereira Nunes, Israel Molina, Desirée Sant’ Anna Haikal, Ester Cerdeira Sabino, Antonio Luiz Pinho Ribeiro   +15 more
doaj   +1 more source

Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection

Vaccines, 2020
Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts.
Nandadeva Lokugamage, Subhadip Choudhuri, Carolina Davies, Imran Hussain Chowdhury, Nisha Jain Garg   +4 more
doaj   +1 more source

Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence

Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Angelina Akomea, Zenabu Lansah Alidu, Gideon Danso, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Joseph Harold Nyarko Osei, Seyram Kofi Loh, William Ekloh, Suraiya Saleem   +13 more
wiley   +1 more source

Unveiling the Silent Regulators: Noncoding RNAs in Parasitic Disease Diagnosis and Therapy

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Parasitic diseases remain a major global health burden, particularly in tropical and low‐resource regions, where limitations in early diagnosis and effective therapeutics contribute to high morbidity and mortality. Emerging evidence highlights noncoding RNAs (ncRNAs) as critical regulators of host–parasite interactions, offering novel opportunities for
Neyon Loku Gamage, Koshila Ranasinghe, Satabdi Datta Choudhury   +2 more
wiley   +1 more source

Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy: Clinical Practice Update

Journal of Education, Health and Sport
Background: Chronic Chagas cardiomyopathy is an arrhythmogenic, fibrosis-prone form of heart failure that develops years after Trypanosoma cruzi infection. Standard therapy has largely been extrapolated from non-Chagas trials.
Katarzyna Skibicka, Weronika Wesołowska, Tomasz Skibicki, Robert Bujak   +3 more
doaj   +1 more source