Results 81 to 90 of about 12,135 (209)

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

Chagas Disease Cardiomyopathy

International Journal of Cardiovascular Sciences, 2018
Abstract Chronic Chagas disease cardiomyopathy (CCC) is a result of low-intensity, but incessant, focal fibrosing myocarditis, caused by persistent T. cruzi infection associated with inflammation, mediated by adverse immune mechanisms. About 30 percent of infected individuals have developed throughout life the chronic cardiac form of Chagas' disease ...
Simões, Marcus Vinicius, Romano, Minna Moreira Dias, Schmidt, André, Martins, Káryta Suely Macedo, Marin-Neto, José Antonio   +4 more
openaire   +3 more sources

Evaluation of VDR gene polymorphisms in Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy [PDF]

, 2016
Vitamin D is an important modulator of the immune response. It acts over several immune cell types where the Vitamin D receptor (VDR) is expressed.
Carmona, F.D., González, Clara Isabel, León Rodríguez, Daniel A., Martín, J.   +3 more
core   +2 more sources

Early Onset Heart Failure due to RBM20 Variant: A Case Report Emphasizing Genetic Diagnosis and Arrhythmic Risk Stratification

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Transthoracic echocardiography demonstrating biventricular dilatation. Parasternal long‐ and short‐axis views and apical four‐ and two‐chamber views show marked left ventricular dilatation with increased end‐diastolic volume, associated with right ventricular dilatation.
Cristian Orlando Porras Bueno, Cesar Augusto Balaguera, Alejandro Mariño Correa, Edward Andrés Cáceres Méndez   +3 more
wiley   +1 more source

Immunopathology of cardiomyopathy in the experimental Chagas disease [PDF]

Memórias do Instituto Oswaldo Cruz, 1999
The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment.
Milena B. P. Soares, Ricardo Ribeirodos Santos   +1 more
openaire   +4 more sources

Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: a Markov model analysis [PDF]

, 2017
Background Chagas disease is currently prevalent in European countries hosting large communities from Latin America. Whether asymptomatic individuals at risk of Chagas disease living in Europe should be screened and treated accordingly is unclear.
Aldasoro, Edelweiss, Angheben, Andrea, Bussion, Sheila, Gascón, Joaquim, Jackson, Yves, Moore, David, Muñoz, Jose, Pinazo, Maria-Jesús, Requena-Méndez, Ana, Sicuri, Elisa   +9 more
core   +3 more sources

Lycopene's Role in Mitigating Obesity‐Induced Cardiac Remodeling: Insights Into Inflammatory and MMP‐2 Pathways

Molecular Nutrition &Food Research, Volume 70, Issue 2, 29 January 2026.
A. Consumption of a highsugar‐fat diet causes excess nutrients, hypertrophy and hyperplasia of adipocytes, causing obesity. Obesity leads to increased inflammatory levels in the heart, which stimulates greater activation of Metalloproteinase‐2 (MMP‐2), which has collagenolytic activity, degrading the collagen network in the heart, ultimately causing ...
Carol Cristina Vagula de Almeida de Silva, Artur Junio Togneri Ferron, Fabiane Valentini Francisqueti‐Ferron, Alexandre Ribeiro da Silva, Silmeia Garcia Zanati Bazan, Jéssica Leite Garcia, Dijon Henrique Salomé de Campos, Mariane Róvero Costa, Daniele Dantas, Heloysa Amaral da Silva, Janaina Paixão das Chagas Silva, Giselle Pinto Faria de Lopes, Bertha Furlan Polegato, Camila Renata Correa, Fernando Moreto, Ana Lucia Anjos Ferreira   +15 more
wiley   +1 more source

Enhancing patient care: a multimodality strategy for dilated cardiomyopathy in Chagas disease [PDF]

Exploration of Cardiology
Chagas disease is a systemic illness characterized by acute and chronic phases. If untreated, it can lead to dysfunction of vital organs, notably the heart, ultimately resulting in heart failure.
Luigy Vasquez-Yeng, Juan Jose Hernandez-Ruiz, Mauricio Garcia-Cardenas, Raul Velazquez-Castañeda, Santiago Luna-Alcala, Pavel Martinez-Dominguez, Enrique C. Guerra, José Armendariz-Ferrari, Nilda Espinola-Zavaleta   +8 more
doaj   +1 more source

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley   +1 more source

Predictive value of clinical and electrophysiological variables in patients with chronic chagasic cardiomyopathy and nonsustained ventricular tachycardia [PDF]

, 2000
OBJECTIVE: Risk stratification of patients with nonsustained ventricular tachycardia (NSVT) and chronic chagasic cardiomyopathy (CCC). METHODS: Seventy eight patients with CCC and NSVT were consecutively and prospectively studied.
De Paola, Angelo Amato Vincenzo, Gondim, Fernando Antônio Aquino, Hara, Vanderlei Mitsuo, Metha, Niraj, Silva, Rose Mary Ferreira Lisboa Da, Távora, Maria Zildany Pinheiro   +5 more
core   +5 more sources