Results 71 to 80 of about 707 (123)

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley   +1 more source

Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy: Clinical Practice Update

Journal of Education, Health and Sport
Background: Chronic Chagas cardiomyopathy is an arrhythmogenic, fibrosis-prone form of heart failure that develops years after Trypanosoma cruzi infection. Standard therapy has largely been extrapolated from non-Chagas trials.
Katarzyna Skibicka, Weronika Wesołowska, Tomasz Skibicki, Robert Bujak   +3 more
doaj   +1 more source

Profile of soluble cell adhesion molecules as potential biomarkers in the cardiac stages of chronic Chagas disease

Frontiers in Immunology
Chagas cardiomyopathy is the most severe chronic manifestation and leading cause of mortality in the disease. Chronic inflammation, resulting from persistent infection by T.
Victor Vaitkevicius-Antão, Bruno Almeida Silva, Michelle da Silva Barros, Cíntia Nascimento da Costa-Oliveira, Byannca de Carvalho Torreão, Ana Carla da Silva, Silvia Marinho Martins, Cristina Carrazone, Wilson Oliveira, Carolina de Araújo Medeiros, Michelle Christiane da Silva Rabello, Virginia Maria Barros de Lorena   +11 more
doaj   +1 more source

Circulating Plasma MicroRNA-208a as Potential Biomarker of Chronic Indeterminate Phase of Chagas Disease

Frontiers in Microbiology, 2018
Chagas cardiomyopathy is the most severe clinical manifestation of chronic Chagas disease. The disease affects most of the Latin American countries, being considered one of the leading causes of morbidity and death in the continent.
Leandra Linhares-Lacerda, Leandra Linhares-Lacerda, Alessandra Granato, João Francisco Gomes-Neto, Luciana Conde, Leonardo Freire-de-Lima, Elisangela O. de Freitas, Celio G. Freire-de-Lima, Shana P. Coutinho Barroso, Rodrigo Jorge de Alcântara Guerra, Roberto C. Pedrosa, Wilson Savino, Wilson Savino, Alexandre Morrot, Alexandre Morrot   +14 more
doaj   +1 more source

Ventricular arrhythmias in Chagas disease

Revista da Sociedade Brasileira de Medicina Tropical, 2015
Sudden death is one of the most characteristic phenomena of Chagas disease, and approximately one-third of infected patients develop life-threatening heart disease, including malignant ventricular arrhythmias.
Marco Paulo Tomaz Barbosa, Andre Assis Lopes do Carmo, Manoel Otávio da Costa Rocha, Antonio Luiz Pinho Ribeiro   +3 more
doaj   +1 more source

Chronic phase of Chagas disease: why should it be treated? A comprehensive review

Memorias do Instituto Oswaldo Cruz, 2011
The pathogenesis and evolutive pattern of Chagas disease suggests that the chronic phase should be more widely treated in order to (i) eliminate Trypanosoma cruzi and prevent new inflammatory foci and the extension of tissue lesions, (ii) promote tissue ...
José Rodrigues Coura, José Borges-Pereira   +1 more
doaj   +1 more source

Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy

Scientific Reports, 2017
Chagas disease cardiomyopathy is a parasite-driven inflammatory disease to which there are no effective treatments. Here we evaluated the therapeutic potential of N,N-dimethylsphingosine(DMS), which blocks the production of sphingosine-1-phosphate(S1P ...
Juliana Fraga Vasconcelos, Cássio Santana Meira, Daniela Nascimento Silva, Carolina Kymie Vasques Nonaka, Pâmela Santana Daltro, Simone Garcia Macambira, Pablo Daniel Domizi, Valéria Matos Borges, Ricardo Ribeiro-dos-Santos, Bruno Solano de Freitas Souza, Milena Botelho Pereira Soares   +10 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Comparação do desfecho entre a cardiopatia chagásica e a miocardiopatia dilatada idiopática Comparison of outcome between Chagas cardiomyopathy and idiopathic dilated cardiomyopathy

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: Pouco se sabe sobre o desfecho dos pacientes com cardiopatia chagásica, em comparação aos pacientes com miocardiopatia dilatada idiopática na era contemporânea. OBJETIVO: Comparar o desfecho dos pacientes chagásicos com insuficiência cardíaca
Amanda Pires Barbosa, Augusto Cardinalli Neto, Ana Paula Otaviano, Bianca Faria Rocha, Reinaldo Bulgarelli Bestetti   +4 more
doaj  

Echocardiographic predictors of mortality in heart failure from Chagas cardiomyopathy: Refining risk stratification with speckle-tracking echocardiography

American Heart Journal Plus
Background: Chagas cardiomyopathy is a major cause of mortality in endemic regions, predicted primarily by left ventricular (LV) systolic function. Speckle-tracking echocardiography (STE)–derived strain is a sensitive tool for assessing ventricular ...
Marcelo Alves Maia, Ester Cerdeira Sabino, Jose Luiz Padilha da Silva, Cesar Augusto Taconeli, Lea Campos de Oliveira, Omar Ribeiro Santos Junior, Ana Isabel Nobre Maia, Fellipe Colares P.G. Versiani, Ariela Mota Ferreira, Antonio Luiz P. Ribeiro, Maria Carmo P. Nunes   +10 more
doaj   +1 more source