Results 51 to 60 of about 707 (123)

Opportunities and Challenges in Chronic Chagas Cardiomyopathy [PDF]

Global Heart, 2015
Chronic Chagas cardiomyopathy (CCC) is the most serious complication of Chagas disease. More than a century after the astute clinician-scientist Carlos Chagas published the etiologic, pathological, clinical, and epidemiological characteristics of the disease that now bears his name [1], much scientific progress has been made.
Mensah, George A., Burns, Kristin M., Peprah, Emmanuel K., Sampson, Uchechukwu K.A., Engelgau, Michael M.   +4 more
openaire   +3 more sources

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

Phytotherapy Research, Volume 40, Issue 5, Page 2878-2894, May 2026.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng, Mingyang He, Haiying Wu, Tianjie Zhang, Yuxia Jiang, Chuanwei Xin, Meiling Zhang, Jiaqi He, Lulu Zheng   +8 more
wiley   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, Volume 183, Issue 10, Page 2256-2272, May 2026.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Prognostic value of the New York Heart Association classification for cardiovascular events and mortality in Chagas cardiomyopathy: a systematic review and meta-analysis with GRADE recommendations [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
Chagas cardiomyopathy is associated with a higher risk of severe cardiovascular events and increased mortality. Among the factors associated with Chagas cardiomyopathy, impairment in functional capacity-commonly assessed using the New York Heart ...
Whesley Tanor Silva, Henrique Silveira Costa, Hytalo de Jesus Silva, Matheus Ribeiro Ávila, Lucas Frois Fernandes Oliveira, Juliana Pereira Silva, Sandylere Moreira Baia Gomes, Alejandro Marcel Hasslocher-Moreno, Pedro Henrique Scheidt Figueiredo, Mauro Felippe Felix Mediano   +9 more
doaj   +2 more sources

Chagas Disease Cardiomyopathy

International Journal of Cardiovascular Sciences, 2018
Abstract Chronic Chagas disease cardiomyopathy (CCC) is a result of low-intensity, but incessant, focal fibrosing myocarditis, caused by persistent T. cruzi infection associated with inflammation, mediated by adverse immune mechanisms. About 30 percent of infected individuals have developed throughout life the chronic cardiac form of Chagas' disease ...
Simões, Marcus Vinicius, Romano, Minna Moreira Dias, Schmidt, André, Martins, Káryta Suely Macedo, Marin-Neto, José Antonio   +4 more
openaire   +3 more sources

Screening for Trypanosoma cruzi infection (Chagas disease) in the Latin American population living with HIV in London

HIV Medicine, Volume 27, Issue 5, Page 796-802, May 2026.
Abstract Background There are an estimated 2482 people born in Latin American countries receiving care for HIV in the United Kingdom. Although national guidance recommends screening for Trypanosoma cruzi infection (Chagas disease) in this population, there is no formal screening programme.
Natalie Elkheir, Shivani Singh, Birgit Barbini, Lucy Campbell, Alice Sharp, Jacqueline O'Connell, Louise Terry, Margherita Bracchi, Javier Rubio, Nicolo Girometti, Mohammed Hassan, Hannah Davies, Frank A. Post, Laura Nabarro, Debbie Nolder, Geraldine O'Hara, Julie Fox, Peter L. Chiodini, David A. J. Moore   +18 more
wiley   +1 more source

Enhancing patient care: a multimodality strategy for dilated cardiomyopathy in Chagas disease [PDF]

Exploration of Cardiology
Chagas disease is a systemic illness characterized by acute and chronic phases. If untreated, it can lead to dysfunction of vital organs, notably the heart, ultimately resulting in heart failure.
Luigy Vasquez-Yeng, Juan Jose Hernandez-Ruiz, Mauricio Garcia-Cardenas, Raul Velazquez-Castañeda, Santiago Luna-Alcala, Pavel Martinez-Dominguez, Enrique C. Guerra, José Armendariz-Ferrari, Nilda Espinola-Zavaleta   +8 more
doaj   +1 more source

The long way to defeating Chagas cardiomyopathy [PDF]

Journal of Nuclear Cardiology, 2019
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Petretta, Mario, Cuocolo, Alberto
openaire   +4 more sources

T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Cardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen‐specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these
Leon Richter, João Dias‐Ferreira, Gustavo Campos Ramos, DiyaaElDin Ashour   +3 more
wiley   +1 more source

Immunopathology of cardiomyopathy in the experimental Chagas disease [PDF]

Memórias do Instituto Oswaldo Cruz, 1999
The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment.
Milena B. P. Soares, Ricardo Ribeirodos Santos   +1 more
openaire   +4 more sources