The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection [PDF]
The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase.
Almeida +48 more
core +2 more sources
TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice [PDF]
Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL),
Basombrío, Miguel Ángel Manuel +8 more
core +3 more sources
Management of trypanosomiasis and leishmaniasis [PDF]
<p>Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress ...
Alsford +39 more
core +2 more sources
The long way to defeating Chagas cardiomyopathy [PDF]
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Petretta, Mario, Cuocolo, Alberto
openaire +4 more sources
Elevated serum levels of macrophage migration inhibitory factor and stem cell growth factor β in patients with idiopathic and systemic sclerosis associated pulmonary arterial hypertension. [PDF]
Pulmonary arterial hypertension (PAH) can be idiopathic or secondary to autoimmune diseases, and it represents one of the most threatening complications of systemic sclerosis (SSc).
Alessandri, Cristiano +9 more
core +2 more sources
ABSTRACT Objective To analyse mortality, hospitalisations and in‐hospital mortality related to paracoccidioidomycosis (PCM) in Brazil, 2000–2024, from a spatio‐temporal and social inequalities perspective. Methods We conducted a mixed ecological study using death certificates from the Mortality Information System and hospital admissions from the ...
Anderson Fuentes Ferreira +9 more
wiley +1 more source
Biomarkers and Mortality in Severe Chagas Cardiomyopathy [PDF]
Chagas cardiomyopathy is a chronic sequela of infection by the parasite, Trypanosoma cruzi. Advanced cardiomyopathy is associated with a high mortality rate, and clinical characteristics have been used to predict mortality risk. Though multiple biomarkers have been associated with Chagas cardiomyopathy, it is unknown how these are related to survival ...
Sherbuk, Jacqueline E. +13 more
openaire +3 more sources
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. [PDF]
BACKGROUND:Familial aggregation of Chagas cardiac disease in T. cruzi-infected persons suggests that human genetic variation may be an important determinant of disease progression.
Xutao Deng +8 more
doaj +1 more source
Canine Trypanosoma cruzi infection in the Bolivian Chaco [PDF]
A cross-sectional study on Trypanosoma cruzi was carried out in 2013 to evaluate the role of dogs as possible source of infection for humans in two rural communities of the highly endemic Bolivian Chaco (Bartolo, Chuquisaca Department, n = 57 dogs; and ...
Bartoloni, Alessandro +9 more
core +2 more sources
Despite matched clinical characteristics and LVEF, patients with Chagas cardiomyopathy exhibit a significantly higher arrhythmic burden compared to ischemic cardiomyopathy. This electro‐mechanical dissociation highlights the necessity of sudden death risk stratification strategies that extend beyond traditional ejection fraction thresholds.
Luis E. Echeverría +7 more
wiley +1 more source

