Results 71 to 80 of about 240,071 (288)

Identification of Potential Trypanosoma cruzi Trans-Sialidase Inhibitors by Computational Drug Repositioning Approaches

Scientia Pharmaceutica
Chagas disease, caused by the parasitic protozoan Trypanosoma cruzi (T. cruzi), represents a worldwide public health issue. To date, there is no efficient treatment to combat this pathology, and the only drugs available are usually toxic to the patient ...
Miguel A. Uc-Chuc, Nohemi Cigarroa-Toledo, Karla Y. Acosta-Viana, José I. Chan-Pérez, Juan C. Pineda-Cortes, Hernán de J. Villanueva-Alonzo   +5 more
doaj   +1 more source

Yellow fever virus isolated from a fatal post vaccination event: an experimental comparative study with the 17DD vaccine strain in the Syrian hamster (Mesocricetus auratus)

Revista da Sociedade Brasileira de Medicina Tropical, 2004
In order to investigate the pathogenicity of the virus strain GOI 4191 that was isolated from a fatal adverse event after yellow fever virus (YFV) vaccination, an experimental assay using hamsters (Mesocricetus auratus) as animal model and YFV 17DD ...
Sueli Guerreiro Rodrigues, Amélia Paes de Andrade Travassos da Rosa, Ricardo Galler, Vera Lúcia Reis de Souza Barros, Conceição de Maria Almeida Vieira, Jorge Fernando Soares Travassos da Rosa, Raimunda do Socorro da Silva Azevedo, Márcio Roberto Teixeira Nunes, Elizabeth Salbé Travassos da Rosa, Pedro Fernando da Costa Vasconcelos   +9 more
doaj   +1 more source

Perspectives on the Trypanosoma cruzi-host cell receptor interaction [PDF]

, 2009
Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions.
A Belley, A Buschiazzo, AC Frasch, AC Monteiro, AC Monteiro, AG Todorov, AJS Augustine, AK Vaidian, AL Leal, AM Celentano, AM Silber, AM Woolsey, Anthony W. Ashton, AP Lima, AW Ashton, AW Ashton, BA Burleigh, BA Burleigh, BA Burleigh, BK Kubata, C Claser, CA Buscaglia, CA Petersen, CW Turner, E Del Nery, E Ortega-Barria, F Leeb-Lundberg, F Marceau, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, Fabiana S. Machado, Fangxia Guan, Fernando Villalta, GS Hassan, HB Tanowitz, HB Tanowitz, HB Tanowitz, HB Tanowitz, Herbert B. Tanowitz, Huan Huang, IC Cuevas, IM Bastos, J Aliberti, J Scharfstein, J Scharfstein, JC Engel, JL Croxford, JM Di Noia, Julio Scharfstein, K Kabashima, KD Bhoola, Kevin M. Tyler, KJ Simmons, KM Tyler, L Sterin-Borda, LO Andrade, Louis M. Weiss, LX Liu, M de Melo-Jorge, M Einicker-Lamas, M Ming, MA Campos, MA Ouaissi, Maria F. Lima, MC Taylor, ME McGrath, MF Lima, MF Lima, MH Magdesian, MJ Alves, MN Meirelles, MV Chuenkova, MV Chuenkova, MV Chuenkova, MV Chuenkova, N Garg, N Garg, N Yoshida, P Grellier, PJ Pereira, PN Nde, R Agusti, R Giordano, R Manning-Cela, RA Skidgel, RL Cardoni, S Favoreto Jr, S Mukherjee, S Mukherjee, S Mukherjee, S Schenkman, S Vaena de Avalos, Sandra Alvarez, SB Petkova, SB Petkova, SG Andrade, Shankar Mukherjee, SM Factor, T Moody, VL Hideko Tatakihara, YY Kleshchenko   +108 more
core   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Poor response to tuberculosis treatment with regimens without rifampicin in immunosuppressed AIDS patients

Brazilian Journal of Infectious Diseases
A prospective study was conducted on 79 advanced immunosuppressed AIDS patients from 1997 to 1999, during which nine cases of tuberculosis (TB) were diagnosed.
M.M. O'Donnel, S. Souza Carvalho, A.J. Gadelha, M.G. Morgado, M.C.G. Galhardo, M.C. Lourenço, V.C. Rolla   +6 more
doaj   +1 more source

Review of Chagas Disease and Treatment Obstacles to Eradication [PDF]

, 2019
The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries.
Sherman, Emily
core   +1 more source

Chagas Disease, France

Emerging Infectious Diseases, 2008
Chagas disease (CD) is endemic to Latin America; its prevalence is highest in Bolivia. CD is sometimes seen in the United States and Canada among migrants from Latin America, whereas it is rare in Europe. We report 9 cases of imported CD in France from 2004 to 2006.
Lescure, François-Xavier, Canestri, Ana, Melliez, Hugues, Jauréguiberry, Stéphane, Develoux, Michel, Dorent, Richard, Guiard-Schmid, Jean-Baptiste, Bonnard, Philippe, Ajana, Faïza, Rolla, Valeria, Carlier, Yves, Gay, Frederick, Elghouzzi, Marie-Hélène, Danis, Martin, Pialoux, Gilles   +14 more
openaire   +3 more sources

Rhenium Complexes as Antimicrobial Agents

Helvetica Chimica Acta, EarlyView.
Rhenium complexes are stepping into the fight against superbugs. Our new review explores how these metallic complexes could inspire the next generation of antimicrobial therapies. ABSTRACT The escalating crisis of antimicrobial resistance (AMR) necessitates the exploration of unconventional therapeutic scaffolds.
Fabio Zobi, Gozde Demirci, Marija Rasic
wiley   +1 more source

MUTATIONS IN INFLUENZA A AND B NEURAMINIDASE ASSOCIATED WITH OSELTAMIVIR RESISTANCE: CONTRIBUTIONS OF GENOMIC SURVEILLANCE IN BRAZIL

Brazilian Journal of Infectious Diseases
Introduction/Objectives: Influenza virus causes flu and leads to a high number of deaths and hospitalizations every year. In severe infections, especially among people at risk for complications, antivirals are key tools for clinical management ...
Luana Soares Barbagelata, Amanda Mendes Silva Cruz, Wanderley Dias das Chagas Júnior, Agatha Monike Silva Nunes, James Lima Ferreira, Karla Fabiane Lopes de Melo, Lumara Silvia Santana Ferreira, Edna Maria Acunã de Souza, Danielle Rodrigues de Deus, Fernando Neto Tavares, Mirleide Cordeiro dos Santos   +10 more
doaj   +1 more source

Incorporating sub-universes to address the issue of chagas in different educational contexts [PDF]

, 2013
Although Chagas has been traditionally addressed just from a biomedical point of view, due to its multiple factors and the diverse actors involved, it is necessary to consider it as a really complex problem characterized by four large dimensions ...
Sanmartino, Mariana
core   +1 more source