Results 61 to 70 of about 97,832 (299)

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium Tuberculosis: Progress Toward Novel Antitubercular Agents

ChemMedChem, EarlyView.
A series of 42 homoisoflavones were synthesized and evaluated against Mycobacterium tuberculosis (Mtb). Three derivatives showed potent inhibition of Mtb strains. Evaluation in infected macrophages revealed promising intracellular activity, where one derivative featuring a nitrofuranyl and piperidine group emerges as the most promising.
Sanderson D. Calixto, Juliane S. Falcão, Stella S. Antunes, Marlon H. Araujo, Alexandre L. B. Cunha, David R. Martins, Sarah M. R. Nascimento, Thatiana L. B. V. Simão, Elena B. Lasunskaia, Nelilma C. Romeiro, Paulo R. R. Costa, Michelle F. Muzitano, Guilherme S. Caleffi   +12 more
wiley   +1 more source

Prevention and control of Chagas Disease : an overview [PDF]

, 2018
Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities ...
Almeida, A. B., Anunciação, C. E., Araujo, P. F., Gomes, C., Lacerda, E. Silveira, Petrofeza, S., Rosa, A. C., Teixeira, Antonio Raimundo Lima Cruz   +7 more
core   +1 more source

The chronic gastrointestinal manifestations of Chagas disease

Clinics, 2009
Chagas disease is an infectious disease caused by the protozoan Trypanosoma cruzi. The disease mainly affects the nervous system, digestive system and heart.
Nilce Mitiko Matsuda, Steven M. Miller, Paulo R. Barbosa Evora   +2 more
doaj   +1 more source

Atrial fibrillation and flutter as global drivers of heart failure: Burden and longitudinal trends over three decades

ESC Heart Failure, EarlyView.
Abstract Aims The study aims to comprehensively evaluate the global burden of heart failure attributable to atrial fibrillation (AF) and atrial flutter (AFL) from 1990 to 2021. Methods Using data from the Global Burden of Disease Study 2021, we estimated the prevalence and years lived with disability (YLDs) of heart failure attributable to AF/AFL ...
Yabin Liu, Jingsi Duan, Yue Wang, Nicola Luigi Bragazzi, Mengying Huang, Huimin Chen, Haijiang Dai, Cheng Ni   +7 more
wiley   +1 more source

Introducing automation to the molecular diagnosis of Trypanosoma cruzi infection: A comparative study of sample treatments, DNA extraction methods and real-time PCR assays [PDF]

, 2018
Background Polymerase chain reaction (PCR) has become a useful tool for the diagnosis of Trypanosoma cruzi infection. The development of automated DNA extraction methodologies and PCR systems is an important step toward the standardization of protocols ...
Abras, Alba, Ballart, Cristina, Berenguer, Pere, Gascón, Joaquim, Gutiérrez, Cristina, Gállego, Montserrat, Llovet, Teresa, Muñoz, Carmen, Pinazo, María-Jesús, Posada, Elizabeth, Roig, Carme, Schijman, Alejandro Gabriel, Tebar, Silvia   +12 more
core   +3 more sources

Chagas Disease, France

Emerging Infectious Diseases, 2008
Chagas disease (CD) is endemic to Latin America; its prevalence is highest in Bolivia. CD is sometimes seen in the United States and Canada among migrants from Latin America, whereas it is rare in Europe. We report 9 cases of imported CD in France from 2004 to 2006.
Lescure, François-Xavier, Canestri, Ana, Melliez, Hugues, Jauréguiberry, Stéphane, Develoux, Michel, Dorent, Richard, Guiard-Schmid, Jean-Baptiste, Bonnard, Philippe, Ajana, Faïza, Rolla, Valeria, Carlier, Yves, Gay, Frederick, Elghouzzi, Marie-Hélène, Danis, Martin, Pialoux, Gilles   +14 more
openaire   +4 more sources

The risk of death according to left ventricular ejection fraction and right ventricular dilatation in 17 321 adults with heart failure from 40 high‐, middle‐ and low‐income countries – A Global Congestive Heart Failure (G‐CHF) study

European Journal of Heart Failure, EarlyView.
Abstract Aims The aim of this study was to describe the prognostic importance of left ventricular ejection fraction (LVEF) versus right ventricular (RV) dilatation and dysfunction in patients with heart failure (HF) from countries of different income levels. Methods and results We enrolled 17 321 participants with HF from 40 countries.
Darryl P. Leong, Philip G. Joseph, Hisham Dokainish, Stefan Störk, John V.V. McMurray, Lisa M. Mielniczuk, Sanjib Kumar Sharma, Andrés Orlandini, Kamilu M. Karaye, Antoni Bayes‐Genis, Tara McCready, Alex Grinvalds, Kumar Balasubramanian, Kelley R. Branch, Kristian Kragholm, Salim Yusuf, on behalf of the G‐CHF Investigators   +16 more
wiley   +1 more source

Congenital Chagas disease in a Bolivian newborn in Bergamo (Italy) [PDF]

, 2018
Chagas disease (CD) is an uncommon disease in Europe. Its epidemiology has changed because of mass migration from Latin America to Europe. Herein we describe a congenital case of CD in a Bolivian newborn in Bergamo, the main city of residence for the ...
Bargiggia, Graziano, D'Antiga, Lorenzo, Farina, Claudio, Gabrielli, Simona, Ortalli, Gaia, Rodari, Paola, Ruggeri, Maurizio   +6 more
core  

Management of trypanosomiasis and leishmaniasis [PDF]

, 2012
<p>Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress ...
Alsford, Alvar, Alvar, Barrett, Barrett, Ben Salah, Berman, Bern, Brun, Brun, Burri, Chappuis, Coura, Croft, Croft, El-Sayed, Frearson, Hailu, Jacobs, Jacobs, Le Loup, Lessa, M. P. Barrett, Miranda-Verastegui, Paine, Pinazo, Priotto, Rassi, Reithinger, Rodgers, S. L. Croft, Stuart, Sundar, Sundar, Sundar, Sundar, Torreele, Vanhollebeke, Vincent, Voogd   +39 more
core   +2 more sources

Multiple causes of death related to Chagas' disease in Brazil, 1999 to 2007

Revista da Sociedade Brasileira de Medicina Tropical, 2012
INTRODUCTION: Chagas' disease is a major public health problem in Brazil and needs extensive and reliable information to support consistent prevention and control actions.
Francisco Rogerlândio Martins-Melo, Alberto Novaes Ramos Junior, Carlos Henrique Alencar, Jorg Heukelbach   +3 more
doaj   +1 more source