Results 81 to 90 of about 1,093,565 (287)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Analysis and Simulation of Meshing Force of Main Chain Drive in Baling Process of Round Baler

Jixie chuandong, 2018
The calculation of meshing force between chain links and sprocket is one of the chain transmission dynamics research focus. An approximate equation of sprocket meshing force is derived,under the condition of the local deformation before and after a ...
Lü Beixuan, Chen Yuren
doaj  

New mode and key technology of series drive of multiple permanent magnet motors for scraper conveyor

Meitan kexue jishu
Intelligent equipment is an inevitable trend for the high-quality development of the coal industry, With the construction of super high mining height and super long working face in coal mine, scraper conveyor has been developing towards heavy and long ...
Qiang ZHANG, Wei LIU, Cong WANG, Jinpeng SU, Junming LIU, Jieying GU, Runxin ZHANG   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Phase-Dependent Chiral Transport and Effective Non-Hermitian Dynamics in a Bosonic Kitaev-Majorana Chain

Physical Review X, 2018
We study a 1D chain of noninteracting bosonic cavities which are subject to nearest-neighbor parametric driving, thus realizing a bosonic Hamiltonian whose form is reminiscent of the celebrated Kitaev model of a 1D p-wave superconductor.
A. McDonald, T. Pereg-Barnea, A. A. Clerk   +2 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Research of the Chain Transmission System Dynamics of Heavy-duty Upender

Jixie chuandong, 2015
The chain transmission system of heavy-duty upender is critical for turning body safe operation and parking,therefore,the reliability analysis of the chain transmission system is indispensable for the research and development of large heavy-load upender ...
Li Hailong, Sun Dengyue, Xu Shimin, Zhou Yulin   +3 more
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Design and Simulation of Bias Fork Chain Drive in Vertical Circular Stereo Garage

Jixie chuandong, 2018
Taking the stereo garage as the research object,the advantages and disadvantages of the stereo garage is analyzed. The vertical circular stereo garage is selected as example,the structural improvement of lift system is carried out,the issue of the chain ...
Wang Qi, Yan Zhengliang, Chen Yuanhua
doaj  

Optimization Design and Analysis of Sprocket Chain Plate Stage Driving Device

Jixie chuandong, 2020
The gear and rack drive devices are used to realize various movements of the stage in modern stage. Aiming at the problems of vibration and noise in the operation of rigid driving device， which affect the stability of stage motion and working environment，
Houjin Zhou, Xue Wang, Yabin Wang, Yi Chen   +3 more
doaj