Results 51 to 60 of about 1,911,223 (288)

SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center [PDF]

, 2011
As nascent polypeptide chains are synthesized, they pass through a tunnel in the large ribosomal subunit. Interaction between specific nascent chains and the ribosomal tunnel is used to induce translational stalling for the regulation of gene expression.
Roland Beckmann, Daniel N. Wilson, Wilson, D., Wilson Daniel N., Mielke Thorsten, Jens Frauenfeld, Thorsten Mielke, Berninghausen, O., Mielke, T., Hoffmann, T., Beckmann, R., Wilson, Daniel N, Frauenfeld, Jens, Seidelt, B., Birgit Seidelt, Berninghausen, Otto, Berninghausen Otto, Frauenfeld Jens, Bhushan, S., Mielke, Thorsten, Shashi Bhushan, Hoffmann Thomas, Seidelt, Birgit, Bhushan, Shashi, Hoffmann, Thomas, Thomas Hoffmann, Otto Berninghausen, Beckmann, Roland, Seidelt Birgit, Beckmann Roland, Daniel N Wilson, Frauenfeld, J., Bhushan Shashi, Beckmann, R, Seidelt, B, Berninghausen, O, Mielke, T, Wilson, DN, Hoffmann, T, Frauenfeld, J,, Bhushan, S   +40 more
core   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Ubiquitin acetylation inhibits polyubiquitin chain elongation [PDF]

The EMBO Reports, 2014
Ubiquitylation is a versatile post-translational modification (PTM). The diversity of ubiquitylation topologies, which encompasses different chain lengths and linkages, underlies its widespread cellular roles. Here, we show that endogenous ubiquitin is acetylated at lysine (K)-6 (AcK6) or K48.
Fumiaki, Ohtake, Yasushi, Saeki, Kensaku, Sakamoto, Kazumasa, Ohtake, Hiroyuki, Nishikawa, Hikaru, Tsuchiya, Tomohiko, Ohta, Keiji, Tanaka, Jun, Kanno   +8 more
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Influence of Hydrogen and Ethanol Addition in Methanogen-Free Mixed Culture Syngas Fermentations in Trickle Bed Reactors

Molecules
The use of mixed cultures in gas fermentations could reduce operating costs in the production of liquid chemicals such as alcohols or carboxylic acids.
Cesar Quintela, Iulian-Gabriel Alexe, Yvonne Nygård, Lisbeth Olsson, Ioannis V. Skiadas, Hariklia N. Gavala   +5 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Advances in bioconversion of organic solid wastes for the preparation of high-value medium-chain fatty acids

能源环境保护
With increasing industrialization and urbanization, organic solid wastes production is rising. Resource utilization of these wastes has become an emerging area of research in ecological and environmental protection.
HE Zilin, REN Weitong, WU Qinglian, GUO Wanqian*   +3 more
doaj   +1 more source

Medium chain fatty acids production by microbial chain elongation: Recent advances

, 2020
Medium-chain fatty acids (MCFAs) and their derivatives have important applications in the energy and chemical industries. The sustainable production of MCFAs from renewable biomass resources using microbial fermentation has become promising. A particular
Zhu, Xinyu, Sompong O-Thong, O-Thong, Sompong, Angelidaki, Irini, Luo, Gang, Zhang, Shicheng, Shicheng Zhang, Gang Luo, Xinyu Zhu, Irini Angelidaki   +9 more
core   +1 more source

mboyle32/Elephant-Trunk-Elongation: Elongation Experimental Data

, 2022
<p>This repository contains all the raw data used for analysis of elongation experiments.</p ...
mboyle32
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source