Results 81 to 90 of about 409,221 (291)

The direct link model for polymer rings as a topological field theory and the second topological moment in dense systems

, 2001
Polymer rings in solution are either permanently entangled or not. Permanent topological restrictions give rise to additional entropic interactions apart from the ones arising due to mere chain flexibility or excluded volume.
Otto, Matthias
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

(E)-N-[2-(Biphenyl-4-ylvinyl)phenyl]furan-2-carboxamide

Acta Crystallographica Section E, 2008
In the title molecule, C25H19NO2, the furyl ring is twisted by 46.3 (1)° with respect to the phenylene ring bearing the amido group. In the stilbene unit, the two phenylene rings (i.e.
Noel F. Thomas, Azhar Ariffin, Khalijah Awang, Seik Weng Ng, Chin Hui Kee   +4 more
doaj   +1 more source

Semigroups, Rings, and Markov Chains

Journal of Theoretical Probability, 2000
We analyze random walks on a class of semigroups called ``left-regular bands''. These walks include the hyperplane chamber walks of Bidigare, Hanlon, and Rockmore. Using methods of ring theory, we show that the transition matrices are diagonalizable and we calculate the eigenvalues and multiplicities.
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

4,4′,6,6′-Tetra-tert-butyl-2,2′-[1,2-phenylenebis(nitrilomethylidyne)]diphenol acetone solvate

Acta Crystallographica Section E, 2008
In the Schiff base molecule of the title compound, C36H48N2O2·C3H6O, the central benzene ring makes dihedral angles of 46.64 (10) and 49.34 (10)° with the two outer benzene rings, and the two outer benzene rings form an angle of 39 ...
Rohana Adnan, Hoong-Kun Fun, Suchada Chantrapromma, Siang Guan Teoh, Naser Eltaher Eltayeb   +4 more
doaj   +1 more source

Structure and dynamics of ring polymers: entanglement effects because of solution density and ring topology

, 2011
The effects of entanglement in solutions and melts of unknotted ring polymers have been addressed by several theoretical and numerical studies. The system properties have been typically profiled as a function of ring contour length at fixed solution ...
Alim K., Angelo Rosa, Auhl R., Baiesi M., Bao X. R., Bishop M., Cates M. E., Cristian Micheletti, de Gennes P.-G., des Cloizeaux J., Doi M., Drube F., Eisenhaber F., Enzo Orlandini, Everaers R., Gonzalez O., Grosberg A., Grosberg A. Y., Halverson J. D., Halverson J. D., Hess B., Hur K., Hur K., Kapnistos M., Katritch V., Kim E.-G., Kremer K., Lahmar F., Lai P.-Y., Luca Tubiana, Marcone B., Marenduzzo D., Matsuda H., Micheletti C., Millett K. C., Moore N. T., Morse D. C., Müller M., Müller M., Orlandini E., Orlandini E., Plimpton S., Quake S. R., Reith D., Rosa A., Rubinstein M., Rubinstein M., Rudnick J., Tsolou G., Tubiana L., Tubiana L., Tzoumanekas C., Tzoumanekas C., Uchida N., Vettorel T., Virnau P., Vologodskii A., Weber C., Wischnewski S. A., Witz G., Zimm B. H.   +60 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

(7R,8S,9S,12S)-1-Benzyloxy-13,14-didehydro-12-hydroxy-2,13-dimethoxy-N-methylmorphinane

Acta Crystallographica Section E, 2011
In the title compound, C26H31NO4, a sinomenine derivative, the angle between the two aromatic rings is 53.34 (4)°. The N-containing ring is in a chair conformation, while the other two non-planar rings are in a half-boat conformation ...
Ai-Shun Ding, Hong-Sheng Gao, Dan Luo, Ning-Fei Jiang, Xing-Liang Zheng   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source