Results 111 to 120 of about 2,186,596 (297)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Diamagnetic structures as a basis of quasi-stationary slow solar wind

Solar-Terrestrial Physics, 2019
The results presented in this review reflect the fundamentals of the modern understanding of the nature of the structure of the slow solar wind (SW) along the entire length from the Sun to the Earth's orbit.
Eselevich V.G.
doaj   +1 more source

Coupled oscillators with power-law interaction and their fractional dynamics analogues

, 2006
The one-dimensional chain of coupled oscillators with long-range power-law interaction is considered. The equation of motion in the infrared limit are mapped onto the continuum equation with the Riesz fractional derivative of order $\alpha$, when ...
Alfimov, Alfimov, Barre, Bouchaud, Braun, Braun, Carreras, Dyson, Dyson, Dyson, Erdélyi, Flach, Flach, Frohlich, Gaididei, George M. Zaslavsky, Gorbach, Ishimori, Klafter, Klafter, Lewin, Meerschaert, Meerschaert, Meerschaert, Metzler, Metzler, Miller, Milovanov, Mingaleev, Montroll, Mukamel, Nickolay Korabel, Oldham, Podlubny, Pokrovsky, Saichev, Samko, Shima, Shlesinger, Sokolov, Tarasov, Uchaikin, Vasily E. Tarasov, Weitzner, Zaslavsky, Zaslavsky, Zaslavsky, Zosimov   +47 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Study on Dispersion, Adsorption, and Hydration Effects of Polycarboxylate Superplasticizers with Different Side Chain Structures in Reference Cement and Belite Cement. [PDF]

Materials (Basel), 2023
Fang Y, Zhang X, Yan D, Lin Z, Ma X, Lai J, Liu Y, Ke Y, Chen Z, Wang Z.   +9 more
europepmc   +1 more source

Importance of chirality and reduced flexibility of protein side chains: A study with square and tetrahedral lattice models

, 2004
In simple models side chains are often represented implicitly (e.g., by spin-states) or simplified as one atom. We study side chain effects using square lattice and tetrahedral lattice models, with explicitly side chains of two atoms.
Bagci, Black, Brady, Bromberg, Chan, Cole, Creamer, Creamer, Cronin, Dill, Dima, Doig, Dukor, Dunbrack, Dunbrack, Dunbrack, Hill, Jie Liang, Jinfeng Zhang, Kirshenbaum, Klimov, Kussell, Kussell, Lau, Liang, Liang, Liu, Lovell, Micheletti, Miranker, Mitchell, Park, Pickett, Richards, Richards, Rong Chen, Schafer, Shakhnovich, Tekaia, Wynn, Xia, Yu, Yu Chen, Zhang   +43 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Transformation behaviour of salts composed of calcium ions and phosphate esters with different linear alkyl chain structures in a simulated body fluid modified with alkaline phosphatase. [PDF]

Sci Technol Adv Mater, 2022
Yokoi T, Mio A, Nakamura J, Sugawara-Narutaki A, Kawashita M, Ohtsuki C.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Assessing the Impact of Sustainability Improvement Options on the Agri-food Supply Chain Governance Structures: Development of an Evaluation Tool

International Journal on Food System Dynamics, 2014
The competitiveness of a supply chain is driven by the ability of supply chain governance structures to adapt to the chains’ continuously changing technical and organizational characteristics.
Cosimo Rota, Cesare Zanasi, Nikolai Reynolds   +2 more
doaj