Results 121 to 130 of about 7,880,129 (337)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Association of mitochondrial copy number variation and T16189C polymorphism with colorectal cancer in North Indian population

Tumor Biology, 2017
Globally, colorectal cancer is the third most common type of cancer. Genetic instability leading to cancer development is one of the major causes for development of cancer.
Bhupender Kumar, Zafar Iqbal Bhat, Savita Bansal, Sunil Saini, Afreen Naseem, Khushnuma Wahabi, Archana Burman, Geeta Trilok Kumar, Sundeep Singh Saluja, M Moshahid Alam Rizvi   +9 more
doaj   +1 more source

Optimal Decision Guidance for the Electricity Supply Chain Integration With Renewable Energy: Aligning Smart Cities Research With Sustainable Development Goals

IEEE Access, 2019
The evolution of the smart cities' research and the relevant discussion on well-being is challenging the design of policies, information systems, and computational methods toward the alignment to Sustainable Development Goals (SDG) of the United Nations.
Malak T. Al-Nory
doaj   +1 more source

Multivariate regular variation of heavy-tailed Markov chains

, 2007
The upper extremes of a Markov chain with regulary varying stationary marginal distribution are known to exhibit under general conditions a multiplicative random walk structure called the tail chain. More generally, if the Markov chain is allowed to switch from positive to negative extremes or vice versa, the distribution of the tail chain increment ...
openaire   +3 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Dynamics of participation in utilization of local value chain services: assessing barriers and enablers in Uganda

Cogent Food & Agriculture
Integrating smallholders into agri-food value chains has become a widely endorsed strategy for transforming food systems and reducing poverty in agrarian communities. However, value chain development initiatives are increasingly criticized for their lack
Emmanuel Bizimungu, Robert Sparrow, Ruerd Ruben, John Recha   +3 more
doaj   +1 more source

Macrophyte biomass predicts food chain length in shallow lakes

Ecosphere, 2015
Food chain length provides insights into how ecosystems function and respond to global change. A recent synthesis has shown that food chain length is significantly related to both ecosystem productivity and ecosystem size.
Jacob P. Ziegler, Christopher T. Solomon, Bruce P. Finney, Irene Gregory-Eaves   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains

Nature Communications
Skeletal muscle is a heterogenous tissue comprised primarily of myofibers, commonly classified into three fiber types in humans: one “slow” (type 1) and two “fast” (type 2A and type 2X).
Roger Moreno-Justicia, Thibaux Van der Stede, Ben Stocks, Jenni Laitila, Robert A. Seaborne, Alexia Van de Loock, Eline Lievens, Diana Samodova, Leyre Marín-Arraiza, Oksana Dmytriyeva, Robin Browaeys, Kim Van Vossel, Lukas Moesgaard, Nurten Yigit, Jasper Anckaert, Anneleen Weyns, Ruud Van Thienen, Ronni E. Sahl, Edmar Zanoteli, Michael W. Lawlor, Michael Wierer, Pieter Mestdagh, Jo Vandesompele, Julien Ochala, Morten Hostrup, Wim Derave, Atul S. Deshmukh   +26 more
doaj   +1 more source

Phenotypic variation of milk fatty acid composition of Pinzgauer cattle breed

Italian Journal of Animal Science, 2018
This paper investigated sources of variation of milk fatty acid (FA, g/100 g total FA) profile routinely predicted by mid-infrared spectroscopy in Pinzgauer dual-purpose cattle breed. A total of 19,578 individual milk samples collected from 1232 cows and
Carmen Loreto Manuelian, Giulio Visentin, Mauro Penasa, Martino Cassandro, Massimo De Marchi   +4 more
doaj   +1 more source