Results 141 to 150 of about 4,033,045 (310)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Transforming a C ₃-Symmetrical Liquid Crystal to a π-Gelator by Alkoxy Chain Variation. [PDF]

ACS Omega, 2018
Sandeep A, Praveen VK, Shankar Rao DS, Krishna Prasad S, Ajayaghosh A.   +4 more
europepmc   +1 more source

Licensing Reflexivity: Unity and variation among selected Uralic languages [PDF]

, 2014
This dissertation analyzes the reflexivity patterns in Uralic languages from the point of view of a minimalist approach to binding. The languages under consideration are five Uralic languages spoken in the Russian Federation: Meadow Mari, Komi-Zyrian ...
Volkova, A.A., Overkoepelend onderzoeksprogramma UiL-OTS, LS Franse Taalkunde, ILS Variation   +3 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Supply Chain Structures Promoting Development of Sustainable Supply Chains: The Case of Surplus Food Recovery

, 2021
Reducing anthropogenic carbon emissions and food waste are complex global sustainability challenges that are impacted of and by supply chain activities. This thesis examines structural aspects of the supply chain in relation to sustainable development by
Sundgren, Caroline
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Multimerization interactions between protein-inspired single-chain random heteropolymers.

PLoS ONE
Single-chain nanoparticles (SCNPs) are attractive for their ability to interact with or behave akin to native proteins. In this work, we use molecular dynamics simulations to examine how SCNPs which are assembled non-covalently due to the hydrophobic ...
Shayna L Hilburg, Tianyi Jin, Priya Ganesh, Alfredo Alexander-Katz   +3 more
doaj   +1 more source

Developing supply chain maturity [PDF]

This study introduces an empirical model of supply chain maturity and assesses its impact upon performance. Findings suggest that supply chain maturity is multi-dimensional including the areas of planning, sourcing, making, delivering, new product ...
Done, Adrian
core