Results 121 to 130 of about 4,033,045 (310)

Pseudorelative, gerundi e infiniti nelle varietà romanze: affinità (solo) superficiali e corrispondenze strutturali [PDF]

, 2013
The main topic of this dissertation is a comparison among sentential predicative constructions in the Romance languages. Whereas Pseudo-relative clauses are almost universally used in the Romance domain (with some parametrical differences), predicative ...
Casalicchio, Jan, ILS Variation
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains

Nature Communications
Skeletal muscle is a heterogenous tissue comprised primarily of myofibers, commonly classified into three fiber types in humans: one “slow” (type 1) and two “fast” (type 2A and type 2X).
Roger Moreno-Justicia, Thibaux Van der Stede, Ben Stocks, Jenni Laitila, Robert A. Seaborne, Alexia Van de Loock, Eline Lievens, Diana Samodova, Leyre Marín-Arraiza, Oksana Dmytriyeva, Robin Browaeys, Kim Van Vossel, Lukas Moesgaard, Nurten Yigit, Jasper Anckaert, Anneleen Weyns, Ruud Van Thienen, Ronni E. Sahl, Edmar Zanoteli, Michael W. Lawlor, Michael Wierer, Pieter Mestdagh, Jo Vandesompele, Julien Ochala, Morten Hostrup, Wim Derave, Atul S. Deshmukh   +26 more
doaj   +1 more source

Macrophyte biomass predicts food chain length in shallow lakes

Ecosphere, 2015
Food chain length provides insights into how ecosystems function and respond to global change. A recent synthesis has shown that food chain length is significantly related to both ecosystem productivity and ecosystem size.
Jacob P. Ziegler, Christopher T. Solomon, Bruce P. Finney, Irene Gregory-Eaves   +3 more
doaj   +1 more source

Buyer focus: evaluation of a new concept for supply chain integration [PDF]

The goal of integrated supply chains is to remove barriers to ease the flow of materials and information. This article concentrates on an important barrier: shared resources in a supply chain.
Vaart, Taco van der, Donk, Dirk Pieter van   +1 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Dynamics of participation in utilization of local value chain services: assessing barriers and enablers in Uganda

Cogent Food & Agriculture
Integrating smallholders into agri-food value chains has become a widely endorsed strategy for transforming food systems and reducing poverty in agrarian communities. However, value chain development initiatives are increasingly criticized for their lack
Emmanuel Bizimungu, Robert Sparrow, Ruerd Ruben, John Recha   +3 more
doaj   +1 more source

Association of mitochondrial copy number variation and T16189C polymorphism with colorectal cancer in North Indian population

Tumor Biology, 2017
Globally, colorectal cancer is the third most common type of cancer. Genetic instability leading to cancer development is one of the major causes for development of cancer.
Bhupender Kumar, Zafar Iqbal Bhat, Savita Bansal, Sunil Saini, Afreen Naseem, Khushnuma Wahabi, Archana Burman, Geeta Trilok Kumar, Sundeep Singh Saluja, M Moshahid Alam Rizvi   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Means-End Analysis of Linkages Between Bank Attributes and Consumer Values: A Correlational Approach

Marketing Management Journal, 1998
Means-end chain theory suggests that attributes are the means through which products and services deliver values to consumers. This study examined the nature of the relationship between bank attributes and consumer values using a regression analysis of ...
RICHARD L. DIVINE, LAWRENCE LEPISTO
doaj   +1 more source